Lipid-Lowering Action of Powder and Water Extract of Mulberry Leaves in C57BL/6 Mice Fed High-Fat Diet

조영숙,; 손미예,; 이미경,

doi:10.3746/jkfn.2007.36.4.405

Cited by 16 publications

(5 citation statements)

References 12 publications

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“…Thus, HDL-c protects the endothelium and lowers the risk of coronary artery disease [26]. Our findings were consistent with those of Cho et al [27], who reported that high HDL-c levels occurred in experimental animals fed an HFD due to an increase in the blood TC content induced by the HFD. However, our results also showed that the AIs in the HFD-EHE100 and HFD-EHE200 groups were significantly lower, at 0.37 ± 0.03 (p < 0.01) and 0.32 ± 0.03 (p < 0.001), respectively, compared to 0.52 ± 0.03 in the HFD group (Fig.…”

Section: Discussionsupporting

confidence: 92%

In vitro Adipocyte Differentiation Inhibition and in vivo Effects on Lipid Metabolism in High-Fat Diet-Induced Obesity of Euphorbia humifusa

Lee,

Kang

2023

J. Microbiol. Biotechnol.

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Section: Discussionsupporting

confidence: 92%

In vitro Adipocyte Differentiation Inhibition and in vivo Effects on Lipid Metabolism in High-Fat Diet-Induced Obesity of Euphorbia humifusa

Lee,

Kang

2023

J. Microbiol. Biotechnol.

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“…Moreover, it is also an excellent source of functional nutraceutical food. Mulberry leaves contain carbohydrates, amino acids, fatty acids, and other bioactive compounds with good anti-oxidation, antibacterial, anti-inflammatory, anti-hypoglycemic, and anti-aging effects ( Srivastava et al, 2006 ; Cho et al, 2007 ; Hunyadi et al, 2012 ; Park et al, 2013 ; Wang et al, 2015 ; Mahboubi, 2019 ). Several value-added products are developed from mulberry leaves such as mulberry tea, salads, and supplement capsules.…”

Section: Introductionmentioning

confidence: 99%

Morus alba L. Leaves – Integration of Their Transcriptome and Metabolomics Dataset: Investigating Potential Genes Involved in Flavonoid Biosynthesis at Different Harvest Times

Cheng

Zhang

et al. 2021

Front. Plant Sci.

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The mulberry leaf is a classic herb commonly used in traditional Chinese medicine. It has also been used as animal feed for livestock and its fruits have been made into a variety of food products. Traditionally, mulberry (Morus alba L.) leaf harvesting after frost is thought to have better medicinal properties, but the underlying mechanism remains largely unsolved. To elucidate the biological basis of mulberry leaves after frost, we first explored the content changes of various compounds in mulberry leaves at different harvest times. Significant enrichment of flavonoids was observed with a total of 224 differential metabolites after frost. Subsequently, we analyzed the transcriptomic data of mulberry leaves collected at different harvest times and successfully annotated 22,939 unigenes containing 1,695 new genes. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed 26, 20, and 59 unigenes related to flavonoids synthesis in three different groups harvested at different times. We found that the expression levels of flavonoid biosynthesis-related unigenes also increased when harvested at a delayed time, which was consistent with the flavonoid accumulation discovered by the metabolomic analysis. The results indicated that low temperature may be a key trigger in flavonoid biosynthesis of mulberry leaves by increasing the expression of flavonoid biosynthesis-related genes. This study also provided a theoretical basis for the optimal harvest time of mulberry leaves.

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“…As an oligophagous insect, the best feeding source for silkworms is mulberry leaves. Mulberry leaves are the optimal feeding source for silkworms, as they contain various nutrients, including mineral elements, proteins, amino acids, and fatty acids, as well as trace bioactive substances, such as phenols, alkaloids, flavonoids, polysaccharides, and volatile oils (Cho et al 2007, Lim and Choi 2019, Li et al 2021, Yang et al 2021). However, the harvest and quality of mulberry leaves are constrained by geographical and seasonal factors, resulting in great restrictions on the development of sericulture (Qin et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Effects of artificial diet rearing during all instars on silk secretion and gene transcription in Bombyx mori (Lepidoptera: Bombycidae)

Yin

Zhang

et al. 2023

Journal of Economic Entomology

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Silkworms (Bombyx mori) reared on artificial diets during all instars have the advantages of simplicity and efficiency, year-round production, and reduced risk of poisoning. However, low silk yield remains a challenge, limiting its industrial application. To address this issue, the spinning behavior, nutrient absorption, and transcriptomics of silkworms were investigated. Compared with silkworms reared on mulberry leaves during all instars, those fed with artificial diets showed significantly lower cocoon weight, cocoon shell weight, cocoon shell rate, and silk gland tissue somatic index at the end of the fifth instar (P < 0.01). The spinning duration and crawling distance of silkworms reared on artificial diets were also significantly lower than those reared on mulberry leaves (P < 0.01). Regarding nutrient absorption, the dietary efficiency indexes of silkworms fed with artificial diets were significantly lower than those fed with mulberry leaves, except for the efficiency conversion of digesta to cocoon (P < 0.01). Further RNA-Seq analysis revealed 386 differentially transcribed genes between the 2 groups, with 242 upregulated and 144 downregulated genes. GO enrichment analysis showed that differential transcriptional genes were mainly enriched in organic acid metabolism, oxidation–reduction, and drug catabolism. KEGG enrichment analysis showed that differential transcriptional genes were mainly enriched in genetic information processing and metabolism pathways. Our findings provide new insights into the silk secretion and can serve as a reference for future research and application of silkworms fed with artificial diets.

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Lipid-Lowering Action of Powder and Water Extract of Mulberry Leaves in C57BL/6 Mice Fed High-Fat Diet

Cited by 16 publications

References 12 publications

In vitro Adipocyte Differentiation Inhibition and in vivo Effects on Lipid Metabolism in High-Fat Diet-Induced Obesity of Euphorbia humifusa

In vitro Adipocyte Differentiation Inhibition and in vivo Effects on Lipid Metabolism in High-Fat Diet-Induced Obesity of Euphorbia humifusa

Morus alba L. Leaves – Integration of Their Transcriptome and Metabolomics Dataset: Investigating Potential Genes Involved in Flavonoid Biosynthesis at Different Harvest Times

Effects of artificial diet rearing during all instars on silk secretion and gene transcription in Bombyx mori (Lepidoptera: Bombycidae)

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