Lipid-lowering effect of 2 dosages of a soy protein supplement in Hypercholesterolemia

Høie, Lars; Graubaum, Hans‐Joachim; Harde, Andrea; Gruenwald, Joerg; Wernecke, Klaus‐D.

doi:10.1007/bf02849888

Cited by 21 publications

(8 citation statements)

References 16 publications

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“…Our search identified 3917 reports, of which 3689 were excluded on the basis of review of titles and abstracts. The remaining 228 articles were reviewed in full, of which 104 provided data for 112 trial comparisons for inclusion in our analyses …”

Section: Resultsmentioning

confidence: 99%

Effect of Plant Protein on Blood Lipids: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Mejía

Lytvyn

et al. 2017

JAHA

100

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BackgroundThere is a heightened interest in plant‐based diets for cardiovascular disease prevention. Although plant protein is thought to mediate such prevention through modifying blood lipids, the effect of plant protein in specific substitution for animal protein on blood lipids remains unclear. To assess the effect of this substitution on established lipid targets for cardiovascular risk reduction, we conducted a systematic review and meta‐analysis of randomized controlled trials using the Grading of Recommendations Assessment, Development, and Evaluation system.Methods and Results MEDLINE, EMBASE, and the Cochrane Registry were searched through September 9, 2017. We included randomized controlled trials of ≥3 weeks comparing the effect of plant protein in substitution for animal protein on low‐density lipoprotein cholesterol, non–high‐density lipoprotein cholesterol, and apolipoprotein B. Two independent reviewers extracted relevant data and assessed risk of bias. Data were pooled by the generic inverse variance method and expressed as mean differences with 95% confidence intervals. Heterogeneity was assessed (Cochran Q statistic) and quantified (I2 statistic). The overall quality (certainty) of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation system. One‐hundred twelve randomized controlled trials met the eligibility criteria. Plant protein in substitution for animal protein decreased low‐density lipoprotein cholesterol by 0.16 mmol/L (95% confidence interval, −0.20 to −0.12 mmol/L; P<0.00001; I2=55%; moderate‐quality evidence), non–high‐density lipoprotein cholesterol by 0.18 mmol/L (95% confidence interval, −0.22 to −0.14 mmol/L; P<0.00001; I2=52%; moderate‐quality evidence), and apolipoprotein B by 0.05 g/L (95% confidence interval, −0.06 to −0.03 g/L; P<0.00001; I2=30%; moderate‐quality evidence).ConclusionsSubstitution of plant protein for animal protein decreases the established lipid targets low‐density lipoprotein cholesterol, non–high‐density lipoprotein cholesterol, and apolipoprotein B. More high‐quality randomized trials are needed to improve our estimates.Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT02037321.

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Section: Resultsmentioning

confidence: 99%

Effect of Plant Protein on Blood Lipids: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Mejía

Lytvyn

et al. 2017

JAHA

100

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“…Both soy-nut and soy-protein had beneficial effects on serum concentrations of total cholesterol, LDL cholesterol, triacylglycerol, and apoB-100. Such results have also been seen among subjects with different types of diseases (Hoie et al, 2005). Beneficial effects of soy consumption on blood lipids were the most consistently reported findings (Hermansen et al, 2005).…”

Section: Accepted Manuscriptmentioning

confidence: 78%

Interplay between proteins and metabolic syndrome–A review

Miglani

Bains

2017

Critical Reviews in Food Science and Nutrition

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Metabolic syndrome is characterized by hypertension; hyperglycemia; hypertriglyceridemia; reduced high-density lipoprotein cholesterol levels and abdominal obesity. Abundant data suggest that, compared with other people, patients meeting these diagnostic criteria have a greater risk of having substantial clinical consequences, the two most prominent of which are the development of diabetes mellitus and coronary heart disease. The metabolic syndrome is a health issue of epidemic proportions. Its prevalence in the world continues to increase, hand in hand with that of obesity. Protein, on the other hand, is the foundation of cell-building, especially in muscle tissue. The body needs protein to build not only muscle cells, but the cells of major organs, skin and red blood cells. For people with metabolic syndrome, one of the other functions of protein is to slow down the absorption of carbohydrates. When proteins are consumed with carbohydrates, it takes longer for the digestive system to break down that meal. This means that the sugar created from those carbohydrates is released at a slower rate, preventing spikes in both blood sugar and insulin. As the understanding of the metabolic syndrome evolves, it is likely that more comprehensive therapeutic options will become available.

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“…The American Heart Association recognizes that eating soy protein can help decrease LDL-c levels by two to seven percent [34,35]. In an another study, it was reported that soy protein decreased LDL-c levels five to six percent [36].…”

Section: Human Studiesmentioning

confidence: 99%

Effect of Phytoestrogens on Lipid Profile: Mini Review

Nagamma

Jagadeesh

Anjaneyulu

et al. 2017

Asian J Pharm Clin Res

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Phytoestrogens are structurally similar to its mammalian counterparts and are capable of producing estrogen-like effects and non-steroidal in nature. Their affinity to bind to the estrogen receptors, a class of cytoplasmic proteins, is far less in comparison to the natural estrogen hormones found in humans and other animals or even the synthetically prepared estrogen and, therefore, are far less potent. Even so, the usage of phytoestrogen in either dietary or supplemental form in postmenopausal women is gaining interest, as opposed to the conventional estrogen replacement therapy (ERT), which was so far being used to alleviate the postmenopausal symptoms and believed, with little experimental/clinical evidence, to cause a significant reduction in the threat of coronary heart diseases (CHD). This usage of phytoestrogen follows from the fact that the overall health risks exerted by ERT outweigh the benefits, and to a little extent, the perception that synthetically prepared, so-called "prescription estrogen" interferes with what is otherwise a natural process. It is crucial to explore the alternatives that mimic the beneficial effects of ERT, especially with regard to the minimization of the risk of developing CHD and further evaluation of the aforementioned risks in terms of lipid profiling while simultaneously keeping the health risks to a minimum. This review discusses the scope of use of phytoestrogen specifically pertaining to lipid profiling, their possible health benefits, and adverse effects if any.

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Lipid-lowering effect of 2 dosages of a soy protein supplement in Hypercholesterolemia

Cited by 21 publications

References 16 publications

Effect of Plant Protein on Blood Lipids: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Effect of Plant Protein on Blood Lipids: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Interplay between proteins and metabolic syndrome–A review

Effect of Phytoestrogens on Lipid Profile: Mini Review

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