2017
DOI: 10.22159/ajpcr.2017.v10i2.15684
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Effect of Phytoestrogens on Lipid Profile: Mini Review

Abstract: Phytoestrogens are structurally similar to its mammalian counterparts and are capable of producing estrogen-like effects and non-steroidal in nature. Their affinity to bind to the estrogen receptors, a class of cytoplasmic proteins, is far less in comparison to the natural estrogen hormones found in humans and other animals or even the synthetically prepared estrogen and, therefore, are far less potent. Even so, the usage of phytoestrogen in either dietary or supplemental form in postmenopausal women is gainin… Show more

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Cited by 5 publications
(4 citation statements)
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“…Several studies suggest that increased phytoestrogen intake, especially in those subjects with preexisting hypercholesterolemia, results in lower serum total cholesterol and low-density lipoprotein levels. It has the ability to prevent the increasing incidence of cardiovascular disease [32], prevent osteoporosis [33], and also has the ability to improve the endothelium-dependent relaxation in ovariectomized rats [34]. This ability causes phytoestrogens to play a role as an antioxidant, antiproliferative, antimutagenic, and antiangiogenic and can improve the degree of health and longevity [7,31,35].…”
Section: Discussionmentioning
confidence: 99%
“…Several studies suggest that increased phytoestrogen intake, especially in those subjects with preexisting hypercholesterolemia, results in lower serum total cholesterol and low-density lipoprotein levels. It has the ability to prevent the increasing incidence of cardiovascular disease [32], prevent osteoporosis [33], and also has the ability to improve the endothelium-dependent relaxation in ovariectomized rats [34]. This ability causes phytoestrogens to play a role as an antioxidant, antiproliferative, antimutagenic, and antiangiogenic and can improve the degree of health and longevity [7,31,35].…”
Section: Discussionmentioning
confidence: 99%
“…Hormone replacement therapy is the current treatment but has severe limitations such as the increased risk of ovarian, breast and endometrial cancers (Chlebowski & Anderson, 2015). The menopausal transition is linked with an increase in triglycerides and LDL, increased risk in cardiovascular disease (CVD), increased tunica intima and tunica media thickness (Ieamtairat et al., 2019; Nagamma et al., 2017). Inflammation of menopause along with dyslipidemia is the source of metabolic syndrome and a causative factor of etiopathogenesis of atherosclerosis (Stachowiak et al., 2015).…”
Section: Introductionmentioning
confidence: 99%
“…The petroleum ether extract was reported to be reducing inflammation significantly in the paw‐edema animal model (Pundarikakshudu et al., 2016). It was reported for pharmacological activities such as antidiabetic, hypolipidemic (Nagamma et al., 2017), hepatoprotective, anticancer, neuroprotective (Anjaneyulu et al., 2018; Bahmani et al., 2016), and immunostimulator properties (Bin‐Hafeez et al, 2003; Zameer et al., 2018). Further, the synthesis of TNF‐α will be modulated by fenugreek methanolic extract.…”
Section: Introductionmentioning
confidence: 99%
“…Consumption of phytoestrogens derived from soy can affect plasma lipoprotein levels (lower LDL cholesterol and increase HDL cholesterol), reduce plasma triglyceride levels, inhibit oxidised LDL and lower blood pressure and C-reactive protein (CRP) [15]. Increased phytoestrogen intake results in lower serum total cholesterol and LDL levels, and in some cases leads to an increase in HDL levels [16].…”
Section: Introductionmentioning
confidence: 99%