Lipid lowering effect of allicin (diallyl disulphide-oxide) on long term feeding to normal rats

Welsh Onion Attenuates Hyperlipidemia in Rats Fed on High-Fat High-Sucrose Diet

“…Extracts of garlic have lowered plasma lipids in rats fed on a diet with or without cholesterol, suggesting that the effect was attributable in part to the depressed synthesis of cholesterol and fatty acid. [1][2][3] The results concerning the hypolipidemic effects of onion on animal models have not been so consistent. A hypolipidemic effect of onion was both found 1) and not found 2) in animals fed with a cholesterol-added diet.…”

“…The hypolipidemic effect of garlic and onion has been well studied. [1][2][3][4] Welsh onion (Allium fistulosum L.) is one of the Allium families that is a popular vegetable in Asian countries and often used for flavoring. Like other Allium vegetables, Welsh onion can be expected as a good source of flavonoids and of many kinds of sulfur compounds.…”

Effects of Aged Black Garlic Extract on Lipid Improvement in Rats Fed with High Fat-Cholesterol Diet

“…마늘은 특유의 냄새와 독특한 맛으로 인하여 예로부터 향신 료와 민간약으로 널리 사용되어 왔으며 최근 들어 높은 사망 률을 나타내는 여러 종류의 암 [1,9]이나 고혈압 [8], 동맥경화 [6], 혈중지질 및 콜레스테롤 저하효과 [3,4,37], 항혈전 [18]의 예 방과 치료에 효능이 있다고 알려지면서 많은 연구가 진행되고 있다. 마늘의 유효성분인 allicin은 마늘 특유의 휘발성 향기 성분으로 마늘조직이 파괴될 때 allinase에 의하여 생성되며 allicin이 분해되면 diallyl sulfide, diallyl disulfide, dithiin, ajoene 등의 휘발성 성분과 S-allylcysteine (SAC), S-allylmercaptocysteine 등의 수용성 유황화합물로 분해되어 효능을 나 타낸다 [23].…”

Chemical Basis for Pharmacological and Therapeutic Actions of Penicillamine

“…These include S-propenyl-L-cysteine sulphoxide, S-allyl cysteine sulphoxide, and cycloalin, and allyl propyl disulphide present in onions and garlic (Augusti 1974, Augusti & Mathew 1974, Schwimmer & Friedman 1972, Carson & Boggs 1966, lenthionine, present in mushrooms (Kyoden et al 1971), cystathionine sulphoxide, present in animal tissues (Datko et al 1975), and ergothioneine, present in Neurospora crassa (Ishikawa et al 1974). …”