Lipid metabolism and TNF‐α secretion in response to dietary sterols in human monocyte derived macrophages

Abstract

Cholesterol loading as a result of dietary lipids depresses the inflammatory response of macrophages and the presence of 7beta-hydroxysterol may exacerbate this effect. In addition, exposure to dietary lipids enhances scavenger receptor activity in macrophages. These results suggest that changes induced by dietary lipids in human macrophage function are related to an increased propensity of the cells to accumulate lipids during the postprandial phase.

Triacylglycerol-rich lipoproteins derived from healthy donors fed different olive oils modulate cytokine secretion and cyclooxygenase-2 expression in macrophages: the potential role of oleanolic acid

“…Previous work has demonstrated that the secretion of the pro-inflammatory chemokine/cytokines, MCP-1, TNF-a, IL-6 and IL-1b by macrophages is down-regulated by CMR, while secretion of the anti-inflammatory cytokine, TGF-b, is unaffected [45,46]. The current study indicates that TRLs also downregulate MCP-1 and IL-6 production by the cells, while having no effect on TGF-b secretion (Fig.…”

Protective effect of Astragalus polysaccharides on ATP binding cassette transporter A1 in THP‐1 derived foam cells exposed to tumor necrosis factor‐alpha

“…It has been localized in atheromatous plaques. Therefore, it is thought to contribute to the development and progression of atherosclerosis by augmenting the local infl ammatory response and altering lipid homeostasis (Naplitano and Bravo, 2005;Vogel et al, 2004). In addition to increasing the uptake of cholesteryl ester (Persson et al, 2008), TNF-α was demonstrated to decrease cellular cholesterol effl ux via the down-regulation of ABCA1 in our previous (Mei et al, 2007) and current study.…”

Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis

“…However, in certain conditions, anti-inflammatory effects of oxysterols have also been reported. Thus, exposure of human macrophages to chylomicron remnant-like particles loaded with 7b-hydroxycholesterol, but not to chylomicron remnant-like particles loaded with 7-ketocholesterol, significantly reduces TNF-a and IL-6 secretion (Napolitano and Bravo, 2005). In addition, when human macrophages were incubated with 7-ketocholesterol, 7b-hydroxycholesterol, 25-hydroxycholesterol, or 27-hydroxycholesterol before exposure to LPS, all oxysterols except 7-ketocholesterol significantly decreased LPS-induced TNF-a secretion (Englund et al, 2001).…”