Lipid Nanoparticles and Liposomes for Bone Diseases Treatment

Abstract

Because of their outstanding biocompatibility, sufficient capacity to control drug release, and passive targeting capability, lipid nanoparticles are one of the world’s most widely utilized drug delivery systems. However, numerous disadvantages limit the use of lipid nanoparticles in clinical settings, especially in bone regeneration, such as challenges in transporting, storing, and maintaining drug concentration in the local area. Scaffolds are frequently employed as implants to provide mechanical support to the damaged area or as diagnostic and imaging tools. On the other hand, unmodified scaffolds have limited powers in fostering tissue regeneration and curing illnesses. Liposomes offer a solid foundation for the long-term development of various commercial solutions for the effective drug delivery-assisted treatment of medical conditions. As drug delivery vehicles in medicine, adjuvants in vaccination, signal enhancers/carriers in medical diagnostics and analytical biochemistry, solubilizers for various ingredients as well as support matrices for various ingredients, and penetration enhancers in cosmetics are just a few of the industrial applications for liposomes. This review introduces and discusses the use of lipid nanoparticles and liposomes and the application of lipid nanoparticles and liposome systems based on different active substances in bone diseases.

Evaluation of Drug-Loaded and Surface-Adsorbed DNase/Tween-80 Solid Lipid Nanoparticles against Staphylococcus aureus Biofilms

“…SLNs can enter the matrix and deliver drugs directly to the cells. Localized, controlled drug delivery at the site of infection is also possible with SLNs, so the chances of an effective outcome are increased. , Drug-loaded NP release profiles were studied at an acidic pH 4.0, physiological pH 7.4, and basic pH 9.0. The release of drugs from SLNs is due to the erosion of core lipids and diffusion .…”

β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model

“…Therapeutic mRNA has shown great success with worldwide vaccination against COVID-19 using mRNA lipid nanoparticles [ [55] , [56] , [57] ]. However, the use of mRNA delivery to address musculoskeletal diseases, specifically for bone healing, remains a nascent field [ 58 ].…”

Cell unit-inspired natural nano-based biomaterials as versatile building blocks for bone/cartilage regeneration

“…Liposomes, which are spherical vesicles made of phospholipid bilayers, have been widely studied as potential drug delivery vehicles due to their ability to encapsulate hydrophilic and hydrophobic drugs. Additionally, lipid nanoparticles have been explored as promising nanocarriers for the delivery of drugs and diagnostic compounds due to their excellent biocompatibility and low toxicity [ 139 ].…”