Lipid nanoparticles for prolonged topical delivery: An in vitro and in vivo investigation

Puglia, Carmelo; Blasi, Paolo; Rizza, Luisa; Schoubben, Aurelie Marie Madeleine; Bonina, Francesco; Róssi, Carlo; Ricci, Maurizio

doi:10.1016/j.ijpharm.2008.01.045

Cited by 243 publications

(126 citation statements)

References 55 publications

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“…Puglia et al also demonstrated that the particles were able to reduce the drug penetration, but increasing, simultaneously, the permeation and the accumulation in the horny layer [25]. These researchers showed that the anti-inflammatory effect drugs can be prolonged in the case of drug loaded nanoparticles compared to the drug solution [25]. The results obtained in the present study and the in vivo data published previously demonstrated that lipid nanoparticles are promising in drug delivery and stimulating new and deeper investigations in the field.…”

Section: In Vitro Percutaneous Absorption Studymentioning

confidence: 98%

“…This highlights the property of the Nap-SLN8 formulation to decrease systemic uptake and systemic adverse effects and thus improving the drug levels achieved at the site of disease. Furthermore, a prolonged antiinflammatory effect could be shown for drug loaded SLNs compared to drug solution [25,39]. Francesco et al also showed that the use of SLN can improve the oil accumulation of the formulation into the skin, while in case of the control solution (conventional formulation) the oil permeation occurred through the skin (less oil in the skin layers) [40].…”

Section: In Vitro Percutaneous Absorption Studymentioning

confidence: 99%

“…Francesco et al also showed that the use of SLN can improve the oil accumulation of the formulation into the skin, while in case of the control solution (conventional formulation) the oil permeation occurred through the skin (less oil in the skin layers) [40]. Puglia et al also demonstrated that the particles were able to reduce the drug penetration, but increasing, simultaneously, the permeation and the accumulation in the horny layer [25]. These researchers showed that the anti-inflammatory effect drugs can be prolonged in the case of drug loaded nanoparticles compared to the drug solution [25].…”

Section: In Vitro Percutaneous Absorption Studymentioning

confidence: 99%

“…Puglia et al, showed that SLNs containing naproxen could be used as a platform for prolonged topical delivery to the skin and thus enhancing the anti-inflammatory effect of the drug [25]. They however did not investigate how the changes in HLB of the system using different proportions of binary mixtures of two surfactants with different HLB values during the preparation of the nanoparticles can change the physicochemical properties of SLNs.…”

Section: Introductionmentioning

confidence: 99%

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The design of naproxen solid lipid nanoparticles to target skin layers

Âkbari

Saeedi

Morteza‐Semnani

et al. 2016

Colloids and Surfaces B: Biointerfaces

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(2016) The design of naproxen solid lipid nanoparticles to target skin layers. Colloids and Surfaces B: Biointerfaces, This version is available from Sussex Research Online: http://sro.sussex.ac.uk/67745/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Graphical Abstract Highlights  Naproxen solid lipid nanoparticles (Nap-SLN) can successfully be prepared by ultrasonication  Properties of these nanoparticles can be optimized by lipid concentrations  HLB of the surfactants played a crucial effect on properties of solid lipid nanoparticles  Nap-SLN increased the drug concentration in skin layer rather than systemic absorption Accepted Manuscript AbstractThe aim of the current investigation was to produce naproxen solid lipid nanoparticles (Nap-SLNs) by the ultrasonication method to improve its skin permeation and also to investigate the influence of Hydrophilic-lipophilic balance (HLB) changes on nanoparticles properties. The properties of obtained SLNs loaded with naproxen were characterized by photon correlation spectroscopy (PCS), transmission electron microscopy (TEM) and differential scanning calorimetry (DSC). FT-IR was also used to investigate any interaction between naproxen and the excipients used at the molecular level during the preparation of the SLNs. The performance of the formulations was investigated in terms of skin permeation and also the retention of the drug by the skin. It was found that generally, with increasing the lipid concentration, the average particle size and polydispersity index (PDI) ...

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Section: In Vitro Percutaneous Absorption Studymentioning

confidence: 98%

Section: In Vitro Percutaneous Absorption Studymentioning

confidence: 99%

Section: In Vitro Percutaneous Absorption Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The design of naproxen solid lipid nanoparticles to target skin layers

Âkbari

Saeedi

Morteza‐Semnani

et al. 2016

Colloids and Surfaces B: Biointerfaces

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“…Furthermore, particles with size ranging from $200-400 nm show an occlusive effect due to a film formation on the skin, which can enhance drug penetration into specific skin layers (Ricci et al, 2005;Puglia & Bonina, 2012). Different examples regarding the benefits associated to the application of lipid nanoparticle strategy to the formulation of products aimed to dermal administration are reported in literature (Puglia et al, 2008;Mitri et al, 2011;Aggarwal & Goindi, 2013).…”

Section: Introductionmentioning

confidence: 99%

Design of solid lipid nanoparticles for caffeine topical administration

et al. 2014

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Caffeine is an interesting compound showing anticancer and protective effects upon topical administration, although its penetration through the skin is compromised by its hydrophilicity. Materials and methods: SLN-CAF were formulated by using a modification of the quasi-emulsion solvent diffusion technique (QESD) and characterized by PCS and DSC analyses. In vitro percutaneous absorption studies were effected using excised human skin membranes (i.e. Stratum Corneum Epidermis or SCE).Results: SLN-CAF were in a nanometric range (182.6 ± 8.4 nm) and showed an interesting payload value (75% ± 1.1). DSC studies suggest the presence of a well-defined system and the successful drug incorporation. Furthermore, SLN-CAF generated a significantly faster permeation than a control formulation over 24 h of monitoring. Discussion and conclusions: SLN-CAF were characterized by valid dimensions and a good encapsulation efficiency, although the active to incorporate showed a hydrophilic character. This result confirms the suitability of the formulation strategy employed in the present work. Furthermore, the in vitro evidence outline the key role of lipid nanoparticles in enhancing caffeine permeation through the skin.

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Solid Lipid Nanoparticles to Improve Brain Drug Delivery

Blasi

Schoubben

Giovagnoli

et al. 2011

Nanotechnologies for the Life Sciences

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1313.1 366 13 Solid Lipid Nanoparticles to Improve Brain Drug Delivery The General Problem of Brain Drug Delivery Basic Brain PhysiologyThe CNS consists of the encephalon or brain, and the medulla spinalis or spinal cord (Figure 13.1 ). Both regions are well protected against trauma, the brain by the skull bones and the spinal cord by the vertebra, while three membranes -the meninges -are positioned in between the brain and the skull bones (Figure 13.1 ). The brain and spinal cord are continuous with one another at the level of the upper border of the atlas vertebra.The dura mater lies directly under the skull, the pia mater lies over the brain, while the arachnoid resides in between the former two. The brain is surrounded by the subarachnoid space , positioned between the pia mater and arachnoid, in which the cerebrospinal fl uid ( CSF ) runs. The CSF, which is produced mainly by the choroid plexus ( CP ), fi lls the ventricles and the subarachnoid space, and is in direct relationship with the brain interstitial fl uid [14] .The brain is one of the most -if not the most -well -protected organs in the human body, with both anatomic and physiological barriers providing protection against the external environment. Indeed, specifi c interfaces tightly regulate the exchanges between the peripheral circulation and the CSF circulatory system. These interfaces include: (i) the CP epithelium (blood/ventricular CSF); (ii) the arachnoid epithelium (blood/subarachnoid CSF); and (iii) the BBB formed by the cerebrovascular endothelium (blood/interstitial fl uid of the brain). By tightly regulating both the entrance and clearance of endogenous and exogenous molecules, these barriers provide an excellent homeostasis of the CNS. Figure 13.1 Schematic representation of the human brain within the skull bones. Meninges Skull Cerebrum Cerebellum Central Sulcus Corpus Callosum Striatum Thalamus Hypothalamus Brain Stem Midbrain Pons Medulla Oblongata Spinal Cord Olfactory Sensors Transverse Fissure 13.2 The General Problem of Brain Drug Delivery 367The BBB, which represents the main obstacle against achieving effective CNS pharmacological treatments [4, 12, 13] , is constituted by the brain microvasculature that, due to its anatomic and physiologic features, greatly restricts the number of drugs that can enter the brain after systemic administration. The volume occupied by the capillary and endothelial cells respectively is about 1% and 0.1% of the brain volume; however, the brain microvasculature develops a total surface area of ∼ 20 m 2 and a total length of ∼ 600 km (Figure 13.2 ) [13] .The brain capillaries present no fenestrae , a small amount of pinocytosis vesicles and particular tight junction s ( TJ s) that are also known as the zonula occludens [15, 16] . The TJs are structures that form a narrow and continuous seal surrounding each endothelial and epithelial cell at the apical border, the aim being to strictly regulate the movement of molecules through the paracellular pathway. The brain microvasculature TJs show some d...

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Lipid nanoparticles for prolonged topical delivery: An in vitro and in vivo investigation

Cited by 243 publications

References 55 publications

The design of naproxen solid lipid nanoparticles to target skin layers

The design of naproxen solid lipid nanoparticles to target skin layers

Design of solid lipid nanoparticles for caffeine topical administration

Solid Lipid Nanoparticles to Improve Brain Drug Delivery

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