Lipid nanoparticles with improved biopharmaceutical attributes for tuberculosis treatment

Breaking barriers: The potential of nanosystems in antituberculosis therapy

“…Various types of NDDS-loaded anti-TB drugs, including nanoemulsions [ 240 ], lipid nanoparticles [ 241 ], metal-based nanoparticles [ 242 ], polymeric nanoparticles [ 240 ], and mesoporous silica nanoparticles [ 243 ]. These nanosystems have presented set of advantages and challenges towards the optimization of new approaches for TB treatment.…”

Mycobacterium biofilms

“…Other approaches for the treatment of mycobacterial biofilms include nanoparticles, phototherapy, phage therapy, vaccines, antimicrobial peptides, and new antibiotics. All of these approaches (and those described above) must be tested not only in vitro , but in experimental in vivo studies and, recently, in clinical practice [ [105] , [106] , [107] , [108] , [109] , [110] , [111] ]. These possibilities, together with the development of new antibiotics active against mycobacterial biofilms, are necessary because of the high degrees of resistance of many of the NTM, and the problems that appear with the treatment of some species, like M. abscessus , that is considered nowadays an emerging species with many treatment problems [ 112 ].…”

The Use of Particulate Systems for Tuberculosis Prophylaxis and Treatment: Opportunities and Challenges

“…Among other interesting strategies, the use of particles is becoming more frequent for both TB prophylaxis and therapy [ 40 ]. Particles not only protect the molecules that are administered from degradation but also facilitate their controlled and directed release to the target cells, allowing dose optimization [ 41 , 42 ]. They also contribute to overcoming the lack of immunogenicity of subunit vaccines, because many of these particles are inherently immunogenic or can be manipulated to promote enhanced antigenic uptake and processing, mediating adaptive immune responses [ 43 ].…”