Lipid Nanoparticulate Drug Delivery Systems: A Revolution in Dosage Form Design and Development

Attama, Anthony A.; Momoh, Mumuni A.; Builders, Philip F.

doi:10.5772/50486

Cited by 62 publications

(42 citation statements)

References 85 publications

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“…SLNs are aqueous colloidal dispersions of which the matrix consists of solidified lipids that are highly structured [67] ( Figure 4). The disadvantages are their particle growth is not always controllable, their unpredictable gelation tendency, their unexpected dynamics of polymorphic transitions, and their inherent low incorporation rate due to the crystalline structure of the solid lipid [69,70]. The particles are prepared either with physiological lipids, or with lipids generally recognised as safe (GRAS).…”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

“…The bilayers are separated from one another by aqueous domains and they enclose an aqueous core. Particle sizes of liposomes for these applications typically range from 25 nm up to several lm and are usually dispersed in an aqueous medium [70,77]. Hydrophobic ingredients will be entrapped in the double layer of the liposomes, whereas hydrophilic ingredients will be entrapped in the aqueous core of the liposome (see Figure 4).…”

Section: Liposomesmentioning

confidence: 99%

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Encapsulation of colorants by natural polymers for food applications

Boer

Imhof

Velikov

2019

Coloration Technology

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Product appearance is an important factor for consumers when determining the quality of a product, and colour is one of the most important factors which contribute to product appearance. Currently, the safety and consumer acceptance of some colorants used in food products, such as titanium dioxide and some synthetic colorants, are under discussion. Therefore, new ways to use natural colorants as alternatives to these suspect colorants for future applications are being investigated. A promising method for increasing the applicability of the often sensitive natural colorants is the encapsulation of these colorants in colloidal particles by natural polymers such as carbohydrates, lipids and proteins. In recent years, micro-and nano-encapsulation have increasingly been used for various purposes concerning several food properties such as colour, flavour and micronutrient content. This technique results in improved stability for the often sensitive natural colorants and presents the possibility of entrapping water-insoluble colorants for improved use in an aqueous system. This paper reviews the main methods that are used for encapsulation by natural polymers, discusses the different types thereof that are used for encapsulation of colorants, and provides a short overview of natural colorants successfully encapsulated in these natural polymers.

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Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Section: Liposomesmentioning

confidence: 99%

Encapsulation of colorants by natural polymers for food applications

Boer

Imhof

Velikov

2019

Coloration Technology

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“…Furthermore, these carriers are well-accepted in the scientific community for therapeutic purposes mainly because its structural units are generally recognized as safe (GRAS) [25]. Additionally, lipids biocompatibility and biodegradability properties as well as their versatility makes them suitable and safe delivery systems for humans, with low or non-associated toxicity [11,26]. The large number of lipid-based nanocarriers developed for ARV delivery justifies a constant updated review.…”

Section: Introductionmentioning

confidence: 99%

Lipid Nanocarriers for Anti-HIV Therapeutics: a Focus on Physicochemical Properties and Biotechnological Advances

Faria¹,

Lopes²,

Neves³

et al. 2021

Preprint

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Since HIV was first identified, and in a relatively short period of time, AIDS has become one of the most devastating infectious diseases of the 21st century. Classical antiretroviral therapies were a major step forward in disease treatment options, significantly improving the survival rates of HIV-infected individuals. Even though these therapies have greatly improved HIV clinical outcomes, antiretrovirals (ARV) feature biopharmaceutic and pharmacokinetic problems such as poor aqueous solubility, short half-life and poor penetration into HIV reservoir sites, which contribute to the sub-optimal efficacy of these regimens. To overcome some of these issues, novel nanotechnology-based strategies for ARV delivery towards HIV viral reservoirs have been proposed. The current review focus on the benefits of using lipid-based nanocarriers for tuning the physicochemical properties of ARVs to overcome biological barriers upon administration. Furthermore, a correlation of these properties and the potential therapeutic outcomes has been established. Biotechnological advancements using lipid nanocarriers for RNA interference delivery for the treatment of HIV infections were also discussed.

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“…Lipid nanoparticles systems (LNs) which have to generation's first, solid lipid nanoparticles (SLN) and second, nanostructured lipid carrier (NLCs) can improve the lymphatic transport of the lipophilic drugs as CC and hence, increase its oral bioavailability 4 . LNs systems were recorded as an advanced drug carrier system than polymeric nanoparticles 5,6 . Advantages of nanostructured lipid carriers (NLCs) over the advantages of polymeric nanoparticles because of the lipid component matrix and its properties, which is physiologically tolerated.…”

Section: Introductionmentioning

confidence: 99%

Screening Study for Formulation Variables in Preparation and Characterization of Candesartan Cilexetil Loaded Nanostructured Lipid Carriers

et al. 2020

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The current study inspects the screening of the formulation components further, evaluates the physicochemical properties of the nanostructured lipid carriers (NLCs) for the antihypertensive drug as Candesartan Cilexetil (CC). The sequence screening of all excipients required for the preparation of NLCs should be performed. Firstly, the solubility of CC in different solid and liquid lipids is the major parameter for the selection of the best one. Precirol® ATO 5, Compritol ® 888 ATO and Glyceryl Monostearate (GMS) were showed the maximum solubility of the CC (1000±4.12 mg, 1500±4.15 mg and 1750±3.16 mg), respectively. Hence, they were selected as the solid lipids for the development of NLCs. Liquid lipids Transcutol® HP (30±2.21 mg/ml), Labrasol® ALF (25±1.32 mg/ml) and CapryolTM 90 (18±1.34 mg/ml) were observed to have good affinity for the drug on systematic screening of different liquid lipids. However, Precirol® ATO 5 was found to has good physical compatibility with Transcutol® HP, Compritol ATO 888 was found to has high physical miscibility with Labrasol® ALF and last GMS was appeared in good affinity and compatibly with CapryolTM 90. Hence, the following binary lipid mixtures (Precirol® ATO 5 - Labrasol® ALF), (Compritol® 888 ATO-Transcutol® HP) and (GMS - CapryolTM 90) were selected for the preparation of NLCs. The liquid–solid lipid mixture in the ratio up to 30:70 was observed to have sufficient melting point (55-59 0C). Lutrol F-68, Lutrol F-127, Cremophore EL and Cremophore® RH. In addition to, the combination of (Lutrol® F68:Cremophore® EL) and (Lutrol® F127: Cremophore® RH) were selected as the main surfactants for the preparation of NLCs formulations because of its good emulsification efficacy and homogeneity for the solid-liquid lipid mix. The prepared formulations were investigated for the different quality issues. All designed formulations observed in nanometer size of particles ranged from (408.9±11.5 to 114.6±8.3 nm) with high encapsulation efficiency around 99%. Also, the obtained results revealed that the ZP of the various formulations was consistently negative surface charge in between ((-13 ±2.3 to27.3±3.7 mV). Finally, formula number nine of CC (CC-NLC9) which composed of GMS (solid lipid), CapryolTM 90 (liquid lipid) and Lutrol® F127: Cremophore® RH (surfactants combination) was selected as the best formulation after the rank order for further investigations in the next work. Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Name: Dr. Mohammed Abdel-Wahab Sayed Abourehab Affiliation: Umm Al-Qura University; Makkah Al-Mukarramah, Saudi Arabia E-mail: maabourehab@uqu.edu.sa Name: Dr. Maha Khalifa Ahmed Khalifa Affiliation: Al-Azhar Universit - Cairo, Egypt E-mail: mahakhalifa.ahmed@hotmail.com Name: Dr. Evren Alğin Yapar Affiliation: Turkish Medicines and Medical Devices Agency, Turkiye E-mail: evren.yapar@yahoo.com Comments of reviewer(s): Similar Articles: FORMULATION AND CHARACTERIZATION OF TOPICAL NANO EMULGEL OF TERBINAFINE A REVIEW ON GOLD NANOPRTICLES SYNTHESIS AND CHARACTERIZATION FORMULATION AND EVALUATION OF ELASTIC LIPOSOMES OF DECITABINE PREPARED BY ROTARY EVAPORATION METHOD

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Lipid Nanoparticulate Drug Delivery Systems: A Revolution in Dosage Form Design and Development

Cited by 62 publications

References 85 publications

Encapsulation of colorants by natural polymers for food applications

Encapsulation of colorants by natural polymers for food applications

Lipid Nanocarriers for Anti-HIV Therapeutics: a Focus on Physicochemical Properties and Biotechnological Advances

Screening Study for Formulation Variables in Preparation and Characterization of Candesartan Cilexetil Loaded Nanostructured Lipid Carriers

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