Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders

Stefanov, Stefan; Andonova, Velichka

doi:10.3390/ph14111083

Cited by 45 publications

(31 citation statements)

References 258 publications

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“…Numerous formulations, such as ufasomes, solid-in-oil nanocarriers, passive and iontophoretic transdermal deliveries, nanostructured lipid carriers (NLCs), nanogels, various surfactants with hydrophilic gels, deformable liposomes, liposomes, and transcutaneous deliveries, have been used for achieving greater efficacy and minimizing side effects associated with the use of methotrexate. Inspite of huge efforts, no efficacious or effective topical dosage forms are available yet commercially [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Hydrophilic Polymer Based Methotrexate Patches: In Vitro and In Vivo Characterization

et al. 2022

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This study attempted to develop and evaluate controlled-release matrix-type transdermal patches with different ratios of hydrophilic polymers (sodium carboxymethylcellulose and hydroxypropyl methylcellulose) for the local delivery of methotrexate. Transdermal patches were formulated by employing a solvent casting technique using blends of sodium carboxymethylcellulose (CMC-Na) and hydroxypropylmethylcellulose (HPMC) polymers as rate-controlling agents. The F1 formulated patch served as the control formulation with a 1:1 polymer concentration. The F9 formulation served as our optimized formulation due to suitable physicochemical properties yielded through the combination of CMC-Na and HPMC (5:1). Drug excipient compatibilities (ATR-FTIR) were performed as a preformulation study. The ATR-FTIR study depicted great compatibility between the drug and the polymers. Physicochemical parameters, kinetic modeling, in vitro drug release, ex vivo drug permeation, skin drug retention, and in vivo studies were also carried out for the formulated patches. The formulated patches exhibited a clear, smooth, elastic nature with good weight uniformity, % moisture uptake, drug content, and thickness. Physicochemical characterization revealed folding endurance ranging from 62 ± 2.21 to 78 ± 1.54, tensile strength from 9.42 ± 0.52 to 12.32 ± 0.72, % swelling index from 37.16 ± 0.17 to 76.24 ± 1.37, and % drug content from 93.57 ± 5.34 to 98.19 ± 1.56. An increase in the concentration of the CMC-Na polymer (F9) resulted in increased drug release from the formulated transdermal patches. Similarly, drug permeation and retention were found to be higher in the F9 formulation compared to the other formulations (F1–F8). A drug retention analysis revealed that the F9 formulation exhibited 13.43% drug retention in the deep layers of the skin compared to other formulations (F1–F8). The stability study indicated that, during the study period of 60 days, no significant changes in the drug content and physical characteristics were found. ATR-FTIR analysis of rabbit skin samples treated with the formulated transdermal patches revealed that hydrophilic polymers mainly affect the skin proteins (ceramide and keratins). A pharmacokinetic profile revealed Cmax was 1.77.38 ng/mL, Tmax was 12 h, and t1/2 was 17.3 ± 2.21. In vivo studies showed that the skin drug retention of F9 was higher compared to the drug solution. These findings reinforce that methotrexate-based patches can possibly be used for the management of psoriasis. This study can reasonably conclude that methotrexate transdermal matrix-type patches with CMC-Na and HPMC polymers at different concentrations effectively sustain drug release with prime permeation profiles and better bioavailability. Therefore, these formulated patches can be employed for the potential management of topical diseases, such as psoriasis.

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Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Hydrophilic Polymer Based Methotrexate Patches: In Vitro and In Vivo Characterization

et al. 2022

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“…Therefore, they are considered as promising DDSs in treating skin disorders. 127 Mahmoud et al developed a promising DDS of oxiconazole nitrate-loaded SLN topical gel to enhance the drug effectiveness for the treatment of tinea infection. 128 They used stearic acid to construct oxiconazole nitrate-loaded SLN.…”

Section: Solid Lipid Nanoparticle and Nanostructured Lipid Carriersmentioning

confidence: 99%

Lipid-Based Nanocarrier Systems for Drug Delivery: Advances and Applications

Zhao

Zhou

et al. 2022

Pharmaceutical Fronts

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Lipid-based nanocarriers have been extensively investigated for drug delivery due to their advantages including biodegradability, biocompatibility, nontoxicity, and nonimmunogenicity. However, the shortcomings of traditional lipid-based nanocarriers such as insufficient targeting, capture by the reticuloendothelial system, and fast elimination limit the efficiency of drug delivery and therapeutic efficacy. Therefore, a series of multifunctional lipid-based nanocarriers have been developed to enhance the accumulation of drugs in the lesion site, aiming for improved diagnosis and treatment of various diseases. In this review, we summarized the advances and applications of lipid-based nanocarriers from traditional to novel functional lipid preparations, including liposomes, stimuli-responsive lipid-based nanocarriers, ionizable lipid nanoparticles, lipid hybrid nanocarriers, as well as biomembrane-camouflaged nanoparticles, and further discussed the challenges and prospects of this system. This exploration may give a complete idea viewing the lipid-based nanocarriers as a promising choice for drug delivery system, and fuel the advancement of pharmaceutical products by materials innovation and nanotechnology.

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“…Therefore, they are considered as promising DDSs in treating skin disorders. 127 Mahmoud et al developed a promising DDS of oxiconazole nitrateloaded SLN topical gel to enhance the drug effectiveness for the treatment of tinea infection. 128 They used stearic acid to construct oxiconazole nitrate-loaded SLN.…”

Section: Solid Lipid Nanoparticle and Nanostructured Lipid Carriersmentioning

confidence: 99%

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2022

Pharmaceutical Fronts

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Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders

Cited by 45 publications

References 258 publications

Formulation and Evaluation of Hydrophilic Polymer Based Methotrexate Patches: In Vitro and In Vivo Characterization

Formulation and Evaluation of Hydrophilic Polymer Based Methotrexate Patches: In Vitro and In Vivo Characterization

Lipid-Based Nanocarrier Systems for Drug Delivery: Advances and Applications

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