Lipid Peroxidation

Yaman, Suzan; Ayhancı, Adnan

doi:10.5772/intechopen.95802

Cited by 21 publications

(29 citation statements)

References 30 publications

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“…In cells, Fe 3+ produced by the Fenton reaction can be reduced back to Fe 2+ by the oxidation of O 2 ●− to O 2, originating a catalytic cycle [ 32 ]. The formed hydroxyl radical is a highly reactive oxidant (half-life of 10 −9 s) extracting hydrogen atoms from lipid molecules, starting lipid peroxidation [ 33 ]. The process of lipid peroxidation involves three main steps: initiation, propagation, and termination ( Figure 2 ).…”

Section: Iron-catalyzed Lipid Peroxidation In Cellsmentioning

confidence: 99%

Nature-Inspired Bioactive Compounds: A Promising Approach for Ferroptosis-Linked Human Diseases?

2023

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Ferroptosis is a type of cell death driven by iron overload and lipid peroxidation. It is considered a key mechanism in the development of various diseases such as atherosclerosis, Alzheimer, diabetes, cancer, and renal failure. The redox status of cells, such as the balance between intracellular oxidants (lipid peroxides, reactive oxygen species, free iron ions) and antioxidants (glutathione, glutathione Peroxidase 4), plays a major role in ferroptosis regulation and constitutes its principal biomarkers. Therefore, the induction and inhibition of ferroptosis are promising strategies for disease treatments such as cancer or neurodegenerative and cardiovascular diseases, respectively. Many drugs have been developed to exert ferroptosis-inducing and/or inhibiting reactions, such as erastin and iron-chelating compounds, respectively. In addition, many natural bioactive compounds have significantly contributed to regulating ferroptosis and ferroptosis-induced oxidative stress. Natural bioactive compounds are largely abundant in food and plants and have been for a long time, inspiring the development of various low-toxic therapeutic drugs. Currently, functional bioactive peptides are widely reported for their antioxidant properties and application in human disease treatment. The scientific evidence from biochemical and in vitro tests of these peptides strongly supports the existence of a relationship between their antioxidant properties (such as iron chelation) and ferroptosis regulation. In this review, we answer questions concerning ferroptosis milestones, its importance in physiopathology mechanisms, and its downstream regulatory mechanisms. We also address ferroptosis regulatory natural compounds as well as provide promising thoughts about bioactive peptides.

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Section: Iron-catalyzed Lipid Peroxidation In Cellsmentioning

confidence: 99%

Nature-Inspired Bioactive Compounds: A Promising Approach for Ferroptosis-Linked Human Diseases?

2023

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“…It is believed that oxidative stress results from an unbalanced population of prooxidant and antioxidant species (Yaman and Ayhanci, 2021). Total antioxidant capacity (TAC) is a commonly used analyte to determine the antioxidant status of biological materials and can determine how well the body fights against free radicals produced by a particular disease (Rubio et al., 2016).…”

Section: Discussionmentioning

confidence: 99%

In vivo anticancer study of sodium 2‐[(4‐oxidobenzylidene)amino]‐6H‐1,3,4‐thiadiazine‐5‐olate against Ehrlich ascites carcinoma via targeting PI3K/mTOR pathway

Rizzk,

El‐Deen,

Behery

et al. 2024

Chem Biol Drug Des

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Abstract1,3,4‐Thiadiazine‐based components have gained the attention as they afford significant intervention for cancer therapy. We aimed at assessing the in vivo antitumor activity of sodium 2‐[(4‐oxidobenzylidene) amino]‐6H‐1,3,4‐thiadiazine‐5‐c (SOTA) versus Ehrlich ascites carcinoma (EAC) cells in female mice's peritoneal cavity. An advantageous interaction of the test compound with the receptors p53 (2J1X), Caspase‐3 (3KJF), mTOR (3QAR), and PI3K (4JPS) was revealed by the docking study. The in vivo study of the test compound against EAC, equated with the EAC control mice, EAC bearing mice that received the test compound by i.p. injection proven a substantial decrease in the viability of tumor cell by 70%. Treatment with the tested compound increased total antioxidants capacity and decreasing malondialdehyde levels. Also, the apoptotic activity of the test compound was confirmed by up regulation of caspase‐3 and p53 and downregulation of PI3K and mTOR. Through the liver, kidney, and heart function assessments, the examined component has no adverse effects on either of the two organs, which were supported by a histological study. Significant positive and negative associations among variables were discovered, according to our research. Through the induction of apoptosis and antioxidant effects, the test compound show potential anticancer activity against EAC cells. The treatment with SOTA eliminated most of the pathological abnormalities brought on by EAC cells in mice, according to the results of tests on the liver, kidney, and heart as well as the histological investigation. Taking together, the tested compound SOTA is promising chemotherapeutic agent as supported by targeting PI3k/mTOR pathway.

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“…Oils lose quality when malondialdehyde builds up in them during storage. This compound is responsible for the oxidation that leads to bad flavors and a rotten smell [40]. Many studies indicated the effect of fortifying different vegetable oils with different materials on the properties of theobarbituric acid.…”

Section: The Effect Of Reinforcement With Different Materials On Theo...mentioning

confidence: 99%

Fortification of Vegetable Oils – A review

Rajab,

Kareem

2023

IOP Conf. Ser.: Earth Environ. Sci.

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This study was conducted for the purpose of knowing the benefits of fortification of oils and their sustainability in a wider way to increase the shelf life of oils and fight free radicals resulting from oxidation and damage of oils by using types of natural or industrial food additives that change the physicochemical properties of oils such as acidity number, peroxide number and fatty acids, and also for the purpose of adding properties Multiple oils, such as increasing the percentage of vitamins and antioxidants in the oil and making it more suitable for human use. This study was conducted in order to find out the benefits of strengthening oils and their sustainability in a wider way to increase the shelf life of oils and fight free radicals resulting from oxidation and damage of oils by using types of natural or industrial food additives that change the physical and chemical properties of oils such as acidity number, peroxide number and fatty acids, and also for the purpose of adding properties to multiple oils, such as increasing the percentage of vitamins and antioxidants in the oil and making it more suitable for human use. Usually, the oil is fortified before the oil is filled and preserved, where a mixture of natural ingredients such as (vitamins, spices, and herbs) is added, or synthetic ingredients such as (BHA, BHT, or TBHQ) are added. Oil fortification as a concept, technology, and quality control processes have been around long enough to be reliable for long-term national production.

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Lipid Peroxidation

Cited by 21 publications

References 30 publications

Nature-Inspired Bioactive Compounds: A Promising Approach for Ferroptosis-Linked Human Diseases?

Nature-Inspired Bioactive Compounds: A Promising Approach for Ferroptosis-Linked Human Diseases?

In vivo anticancer study of sodium 2‐[(4‐oxidobenzylidene)amino]‐6H‐1,3,4‐thiadiazine‐5‐olate against Ehrlich ascites carcinoma via targeting PI3K/mTOR pathway

Fortification of Vegetable Oils – A review

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