Lipid Peroxidation and Antioxidant Status in Male and Female Patients with Type 1 and Type 2 Diabetes Mellitus

Madhikarmi, Nirjala Laxmi; Singh, Prem Prakash; Khatun, Tarannum

doi:10.3126/medphoenix.v1i1.17880

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…Extravascular mechanisms of RBC destruction may involve changes in cell deformability and antigenicity. Our observation of increased malondialdehyde levels is agreement with the literature reports and to decrease the membrane fluidity, deformability, visco-elasticity and life span of erythrocytes in the obese subjects, [18][19][20][21] which might be responsible for the initiation of complications such as diabetes, hypertension, hyperlipidemia etc. in obese subjects later on in the north western Indian population.…”

Section: Discussionsupporting

confidence: 91%

Comparative Study on Malondialdehyde and Certain Antioxidants in North West obese Indians

Singh¹,

Singh²

2015

JCDR

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Background: Obesity is one of the most common health problems in developed and developing nations like India. In addition, obesity is considered as a principal risk factor in the initiation of various non communicable chronic diseases such as dyslipidemia, atherosclerosis, cardiovascular, non-insulin dependent diabetes mellitus etc. The pathogenesis of these diseases is associated with oxygen-derived free radicals. Aim: The aim of the study was to analyze oxidative status in obese subjects with respect to normal healthy subjects. Material and Methods: The present study was performed in 50 obese men (BMI>46 kg/m 2) and equal number of normal healthy men (BMI< 27 kg/m 2) and the levels of malondialdehyde, antioxidant enzymes/molecules like superoxide dismutase, catalase reduced glutathione, glutathione reductase, glutathione peroxidase, antioxidant Vitamin-E and Vitamin-C along with total antioxidant activity were evaluated. Results: A significant increase (p<0.01) in the concentration of malondialdehyde by 61.07% was observed in obese men subjects in comparison to normal healthy men subjects while a significant fall was recorded in the levels of vitamin-E (19.54%, p<0.05), Vitamin-C (18.07%, p<0.05), superoxide dismutase (19.51%, p<0.05), catalase (20.28%, p<0.05), GSH (36.56%, p<0.05), GR (33.28%, p<0.01), GPx (19.14%, p<0.05) and a significant decrease by 33.33% (p<0.01) was observed in the total antioxidant activity in obese subjects as compared to normal healthy control subjects. Conclusion: Aforementioned observations suggested that oxidative is induced in the obese subjects (BMI>46 kg/m 2) due to alterations in the malondialdehyde and other oxidative stress markers such as Vitamin-E, Vitamin-C, Superoxide dismutase, catalase, reduced glutathione, glutathione reductase and glutathione peroxidase might be responsible for the etiology of diseases like diabetes, cancer arthritis, atherosclerosis etc. and therefore, obesity should be treated with the same attention of noncommunicable diseases like atherosclerosis, arthritis, diabetes, cancer etc.

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Section: Discussionsupporting

confidence: 91%

Comparative Study on Malondialdehyde and Certain Antioxidants in North West obese Indians

Singh¹,

Singh²

2015

JCDR

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“…Diabetics exhibited higher serum peroxidation levels expressed as malondialdehyde (MDA) before falciparum malaria. This baseline observation supports numerous reports and confirms the central role of oxidative stress in diabetes pathogenesis [ 24 , 25 ]. Indeed, the hyperglycaemia, which is a characteristic feature of diabetes, activates several biochemical pathways that ultimately give rise to products that cause oxidative stress.…”

Section: Discussionsupporting

confidence: 92%

Increased Oxidative Stress and Inflammation Independent of Body Adiposity in Diabetic and Nondiabetic Controls infalciparumMalaria

Acquah

Boampong

Eghan

2016

BioMed Research International

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Information on the extent to which oxidative stress and inflammation occur in the presence of falciparum malaria and type 2 diabetes mellitus in the same individual is limited. This study sought to investigate the extent of inflammation and oxidative stress in adult uncomplicated malaria by measuring fasting levels of lipid peroxides, C-reactive protein (CRP), and total antioxidant power (TAP) before and during falciparum malaria, in 100 respondents with type 2 diabetes and 100 age-matched controls in the Cape Coast metropolis of Ghana. Also, body adiposity index, body mass index, and waist-to-hip ratio were computed. Before and during falciparum malaria, diabetes patients exhibited higher (P < 0.05) levels of CRP and peroxides than controls but TAP and BAI were comparable (P > 0.05) between the two groups. Baseline CRP correlated positively (r = 0.341, P = 0.002) with peroxide only in the diabetic group. During malaria, TAP level in both study groups declined (P < 0.05) by 80% of their baseline levels. CRP correlated negatively (r = −0.352, P = 0.011) with TAP in the control but not the diabetic group. Uncomplicated falciparum malaria elevated inflammation and peroxidation but decreased antioxidant power independent of adiposity. This finding may have implication on cardiovascular health.

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“…16 In general, the overall effect of lipid peroxidation is to decrease membrane fluidity, deformability, visco elasticity. 17 Oxidative stress also causes, conformation changes in membrane cytoskeleton protein which alters fluidity of the membrane, erythrocyte shape, size and osmotic fragility. 18 The level of nervonic acid (a fatty acid normally present only in sphingomyelins-rigidifying agent of the cell membrane) was significantly higher in the obese group.…”

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confidence: 99%

Impact of waist circumference on red blood cells size in obese adults

Babitha

Ramanathan

2016

Int J Res Med Sci

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INTRODUCTIONObesity has become a worldwide issue. Incidence and prevalence of obesity is increasing day by day because of change in life style patterns. We are living in an 'obesogenic environment', in which there is easy availability of energy-dense rich foods such as sweets, sugary drinks and fast food. Since the requirement for physical effort in home and at work is also reduced, there is continuous increase in the rate of over weight and obesity. Apart from the social stigma created, obesity acts as a key factor for diabetes, cardiovascular diseases, osteo arthritis, lipid disorders, sleep apnoea, and certain type of ABSTRACT Background: Obesity is a chronic disease of multifactorial origin. Major cause for obesity is imbalance between energy intake and energy expenditure. One among the important public health problem in developing countries is increase in the prevalence of obesity. Obesity can be general obesity and central obesity. The central obesity is more dangerous than general obesity, since the central obesity reflects abdominal visceral fat, which acts as an endocrine organ and release several pro inflammatory cytokines, which leads to oxidative stress which in turn causes anisocytosis (variation in the size of the RBCs). Waist circumference indirectly measures this abdominal obesity. This study is aimed at finding the impact of Waist circumference on RBC size in obese adults. Methods: This study was done in 100 subjects in the age group 25 to 50 years (50 control with normal waist circumference and 50 obese subjects with increased waist circumference) of Annapoorana Medical college hospitals. Patients with anaemia, malnutrition, and other chronic diseases who are RBCs may show anisocytosis were excluded. Waist circumference was measured. Peripheral smear was prepared and stained with leishman's stain. Smear was focused under oil immersion objective, and the image was captured using a digital camera. Image was transferred to the computer system and RBC diameter was measured using UTHSCA image tool software. Variation in size of the RBCs between control and subjects was compared using Pearson's product moment correlation coefficient and Paired sample t test. Results: The variation in the size of RBCs (anisocytosis) was more in subjects with increased waist circumference when compared with subjects of normal waist circumference. By using Pearsons product moment correlation coefficient, significant r value of 0.5 and 0.7 were got in male subjects and female subjects respectively. Comparing waist circumference and anisocytosis using Paired sample t test, significant p value of ˂ 0.05 was got in male and female obese subjects. Conclusions: The oxidative stress caused by the cytokines released by the adipocytes causes decreased deformability of RBCs and cause anisocytosis, which further causes complications.

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Lipid Peroxidation and Antioxidant Status in Male and Female Patients with Type 1 and Type 2 Diabetes Mellitus

Cited by 3 publications

References 16 publications

Comparative Study on Malondialdehyde and Certain Antioxidants in North West obese Indians

Comparative Study on Malondialdehyde and Certain Antioxidants in North West obese Indians

Increased Oxidative Stress and Inflammation Independent of Body Adiposity in Diabetic and Nondiabetic Controls infalciparumMalaria

Impact of waist circumference on red blood cells size in obese adults

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