Lipid peroxidation and antioxidant vitamins in urolithasis

Abstract

The present, study was conducted to determine the level of malondialdehyde (MDA) as an index of free radial induced lipid peroxidation and antioxidant vitamins -vitamins A, vitamin C and vitamin E in Address for Correspondence :Dr. W. Gyaneshwar Singh Professor and Head, Department of Biochemistry Regional Institute of Medical Sciences, Imphal, Manipur. Pin-795004 • E-mail : wg_singh@yahoo.co.in initiation of calcium oxalate formation are still not known. However the oxidant (free radical production) and antioxidant imbalance may be one of the major factors leading to the process of crystal deposition in renal tissues (2). Manipur is a small State in the North Eastern corner of India where the incidence of urolithiasis is very high among the natives who are different in food habits, and also socially, culturally and ethnically from the people of the mainland of India. The present study is therefore taken to evaluate the role of lipid peroxidation and antioxidant vitamins in the etiology of stone formation in population of Manipur.

Aqueous extract ofBoerhaavia diffusaroot ameliorates ethylene glycol-induced hyperoxaluric oxidative stress and renal injury in rat kidney

“…Hyperoxaluric treatment caused extensive CaOx crystal deposition in kidneys of untreated rats accompanied by oxidative damage as reflected from increased levels of markers of oxidative injury such as MDA and protein carbonyl content and decreased activities of antioxidant enzymes along with GSH level. MDA is a major end product of lipid peroxidation in membrane fatty acids representing oxidative tissue damage caused by ROS resulting in structural alteration of membrane with release of cell and organelle contents, loss of essential fatty acids with formation of cytosolic aldehyde and peroxide products (Kato et al, 2007). In the present investigation, the level of MDA was found to be significantly elevated with oxalate exposure in hyperoxaluric rats.…”

Effects of Zinc Glycine Chelate on Oxidative Stress, Contents of Trace Elements, and Intestinal Morphology in Broilers

“…SOD, GSH, CAT, and MDA are the marks for oxidative stress because they are involved in the antioxidant defense system leading to potential damage due to oxidative stress [30][31][32]. In this experiment, supplementation with 90 mg/kg Zn-Gly increased the activity of Cu/Zn-SOD and GSH-P X and lowered the level of MDA in livers of 21-day broilers.…”

Protective effects of Radix Pseudostellariae polysaccharides against exercise-induced oxidative stress in male rats

“…Lipid peroxidation represents oxidative tissue damage caused by hydrogen peroxide, superoxide anions and hydroxyl radicals, resulting in structural alteration of the membrane, release of cell and organelle content and loss of essential fatty acids with formation of cytosolic aldehyde and peroxide products (24). MDA is a secondary product generated during the oxidation of polyunsaturated fatty acids, which has been frequently measured as an indicator of lipid peroxidation and oxidative stress in vivo (25).…”

“…MDA is a secondary product generated during the oxidation of polyunsaturated fatty acids, which has been frequently measured as an indicator of lipid peroxidation and oxidative stress in vivo (25). Numerous studies have observed that strenuous physical exercise induces increases in the MDA concentration in tissues (24,26,27). As shown in Fig.…”