Protective effects of Radix Pseudostellariae polysaccharides against exercise-induced oxidative stress in male rats

Chen, Zichao; Li, Shanshan; Wang, Xiaoqin; Zhang, Chuan Long

doi:10.3892/etm.2013.942

Cited by 31 publications

(17 citation statements)

References 24 publications

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“…Each of these antioxidant enzymes performs a reduction of a particular ROS. Several studies have reported a significant decrease in SOD, GPx, and CAT activity after exhaustive exercise [11,16,19]. The decrease in the activity of these enzymes may predispose tissues to free radical damage.…”

Section: Discussionmentioning

confidence: 99%

“…In the past three decades, several studies have indicated that oxidative stress can result in extensive lipid, protein, and DNA damage, which may lead to cell dysfunction, aging, carcinogenesis, and neurodegenerative and cardiovascular diseases [15]. Accumulated evidence has shown that increased antioxidant enzyme activity, increased resistance to oxidative stress, and lower levels of oxidative damage may protect against oxidative stressrelated damage to tissues and, on a microscopic level, to cellular macromolecules [15,16].…”

Section: Discussionmentioning

confidence: 99%

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Effect effects of Auricularia auricula polysaccharides on exhaustive swimming exercise-induced oxidative stress in mice

Huang¹

2014

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect effects of Auricularia auricula polysaccharides on exhaustive swimming exercise-induced oxidative stress in mice

Huang¹

2014

Trop. J. Pharm Res

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“…GPx utilizes reduced glutathione (GSH) as a hydrogen donor for the removal of peroxides. CAT catalyzes the breakdown of hydrogen peroxide to form water, sharing this function with GPx [20]. Therefore, the improvement in the antioxidant enzymes activities can help to fight against fatigue.…”

Section: Effects Of Genistein On Serum Antioxidant Enzymes Of Micementioning

confidence: 99%

“…The protocol was adapted from a previous study with some modifications [10]. Briefly, the mice were dropped individually into an acrylic plastic pool (50 cm × 50 cm × 40 cm) filled with water to 30 cm deep and maintained at a temperature of 25 ± 0.5°C.…”

Section: Forced Swimming Testmentioning

confidence: 99%

Anti-fatigue Effects of the Genistein Supplementation in Mice Subjected to Forced Swimming Test

Hu¹

2016

Proceedings of the 2016 International Conference on Biomedical and Biological Engineering

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Abstract. The present study was designed to evaluate the anti-fatigue effects of genistein in mice subjected to the forced swimming test. Mice were divided into four groups, i.e., one control group and three genistein treated groups. The treated groups were received doses of genistein (7, 15 and 30 mg/kg) dissolved in 1.0 mL of physiological saline, and the control group received same volume of physiological saline via oral gavage once a day. After 28 days, the mice were subjected to the forced swimming test, along with the determination of exhaustive swimming times and some biochemical parameters. The results showed that genistein could prolong exhaustive swimming time of mice, which was accompanied by decreases in blood lactic acid (BLA) and serum urea nitrogen (SUN) levels, increases in liver and muscle glycogen contents, and superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) levels in serum. This indicated that genistein had anti-fatigue effects.

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“…Urea is formed in the liver as the end product of protein metabolism (Chen et al, 2013). During digestion, protein is broken down into small peptides and amino acids.…”

Section: Effects Of Pgp On Blood Urea Nitrogenmentioning

confidence: 99%

Effects of Polysaccharides from Gynostemma Pentaphyllum (Thunb.), Makino on Physical Fatigue

Lin-Na¹,

Yong-Xiu²

2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Gynostemma pentaphyllum (Thunb.) Makino has been reported to have a wide range of health benefits in Chinese herbal medicines. Polysaccharides from Gynostemma pentaphyllum (PGP), has been identified as one of the active ingredients responsible for its biological activities. Although many pharmacological activities of PGP have received a great deal of attention, there is limited evidence for the anti-fatigue effects of PGP. The purpose of this study was to investigate the effects of polysaccharides from PGP on physical fatigue. Materials and method: The rats were divided into four groups, with 10 animals per group: control (C), group, low-treated (LT), group, mediumtreated (MT), group, and high-treated (HT), group. The C group received distilled water, while LT, MT and HT groups were given various doses of PGP (100, 200, 400 mg/kg· d). After 30 days, forced swimming test was carried out in an acrylic plastic pool, then the exhaustive swimming time of rats and some biochemical parameters related to fatigue were measured. The data obtained showed that PGP could extend the exhaustive swimming time of the rats, as well as decrease the blood lactic acid (BLA), and blood urea nitrogen (BUN), concentrations, and increase the hemoglobin, liver glycogen and muscle glycogen concentrations. Result: The data obtained showed that different doses of PGP could extend the exhaustive swimming time of the rats, as well as decrease the BLA and BUN concentrations, and increase the hemoglobin, liver glycogen and muscle glycogen concentrations, which suggests that PGP had significant anti-fatigue effects on rats. Conclusion: PGP may be of use as a potential anti-fatigue agent, but there is a need for further research on long-term use in order to show its positive effects on physical fatigue.

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Protective effects of Radix Pseudostellariae polysaccharides against exercise-induced oxidative stress in male rats

Cited by 31 publications

References 24 publications

Effect effects of <i>Auricularia auricula</i> polysaccharides on exhaustive swimming exercise-induced oxidative stress in mice

Effect effects of <i>Auricularia auricula</i> polysaccharides on exhaustive swimming exercise-induced oxidative stress in mice

Anti-fatigue Effects of the Genistein Supplementation in Mice Subjected to Forced Swimming Test

Effects of Polysaccharides from <i>Gynostemma Pentaphyllum</i> (Thunb.), Makino on Physical Fatigue

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