Lipid peroxidation and vitamin E status in gestational diabetes mellitus

Santra, Debjyoti; Sawhney, Harjeet; Aggarwal, Neelam; Majumdar, S.; Vasishta, Kala

doi:10.1046/j.1341-8076.2003.00127.x

Cited by 21 publications

(16 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our finding on such significant decrease of vitamin E in GDM is in harmony with those reported earlier [10, 11, 14] and contrary to others [8, 12] who have reported increase in vitamin E level during the development of GDM. Another antioxidant, vitamin A was also found to decrease in its contents significantly; 11.2% and 26.7% as compared to pregnant and non-pregnant respectively, which is consonant with the report [10] but different from others [13] who reported no change in its level in GDM.…”

Section: Discussionsupporting

confidence: 92%

“…However, there is no consensus on the pathophysiological events underlying oxidative stress in diabetic patients, especially in pregnancy (GDM). Even, there is no consistency in the various reports regarding the levels of MDA contents and vitamins A, E and C in the plasma/blood of gestational diabetics as compared to the normal pregnant [8-15]. So far available data regarding prooxidant and antioxidant status in gestational diabetes are insufficient and controversial.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant Vitamins and Lipoperoxidation in Non-pregnant, Pregnant, and Gestational Diabetic Women: Erythrocytes Osmotic Fragility Profiles

et al. 2010

View full text Add to dashboard Cite

BackgroundInconsistent reports are available in the literature regarding the oxidative status and antioxidant capacity during the pathogenesis of gestational diabetes. Present study was aimed to evaluate oxidative stress during the development of gestational diabetes and to evaluate antioxidant capability in non-pregnant (control), pregnant and gestational diabetics.MethodsThe study consisted of non-pregnant, healthy pregnant and patients suffering from gestational diabetes mellitus (GDM). Each group consisted of 23 women. We compared their oxidative and anti-oxidative system in blood. Their blood malondialdehyde (MDA) and antioxidant vitamins (C, E, A) were determined and compared to evaluate the oxidative status and anti-oxidative capacity of these groups. We have also compared the osmotic fragility profiles of the erythrocytes of these groups.ResultsPlasma MDA content in pregnant was significantly higher compared to non-pregnant (p < 0.001, 67.5%) and even in gestational diabetics; its value was found significantly further elevated (p = 0.001, 13.8%) compared to healthy pregnant. There was significant decline (p < 0.001, 41.9%) in the level of vitamin C in pregnant as compared to non-pregnant. Although in GDM the decrease was significant (p = 0.025, 20.6%) but comparatively lesser when compared to healthy pregnant. Vitamin E showed the increase of 9.6% during pregnancy, although this alteration was non-significant (p = 0.09), but the level was found to decline significantly (p < 0.001, 25.5%) in GDM compared to pregnant group. Vitamin A contents were also decreased in pregnant (p = 0.002, 17.4%) compared to non-pregnant and in GDM (p = 0.012, 11.2%) compared to pregnant group. Osmotic fragility (O.F.) profiles showed insignificant (p = 0.325) enhanced mean erythrocyte fragility (MEF) in pregnant but this increase was significant (p = 0.003) in case of GDM. The O.F. profiles of pregnant and GDM erythrocytes got shifted to the right side of the control one.ConclusionsOur findings indicate highly enhanced lipid peroxidation and significant depletion in antioxidant capacity during the development of gestational diabetes, and these alterations are not the cause but the consequence of GDM. However, further studies are warranted to examine a wider range of biochemical parameters to evaluate the potential risks of oxidative damage in GDM.KeywordsGestational diabetes; Oxidative stress; Anti-oxidants; Vitamins C, E, A; Osmotic fragility; Non-pregnant; Pregnant; GDM

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Antioxidant Vitamins and Lipoperoxidation in Non-pregnant, Pregnant, and Gestational Diabetic Women: Erythrocytes Osmotic Fragility Profiles

et al. 2010

View full text Add to dashboard Cite

show abstract

“…There are studies demonstrating no significant difference between MDA levels of pregnant women with GDM and those of normal pregnant women [19,20] , while other studies demonstrate significantly elevated MDA levels in babies and mothers with GDM compared to those of normal pregnant women [21,22] . We have demonstrated significantly increased maternal and cord plasma levels of MDA in gestational diabetic pregnancies.…”

Section: Discussionmentioning

confidence: 92%

The Incidence of Placental Abnormalities, Maternal and Cord Plasma Malondialdehyde and Vascular Endothelial Growth Factor Levels in Women with Gestational Diabetes Mellitus and Nondiabetic Controls

Madazli

Tüten

Calay³

et al. 2008

Gynecol Obstet Invest

112

View full text Add to dashboard Cite

Background/Aims: To evaluate the incidence of placental abnormalities, cord plasma erythropoietin (EPO) levels and nucleated red blood cell (NRBC) counts, maternal and cord plasma malondialdehyde (MDA) and vascular endothelial growth factor (VEGF) levels in women with gestational diabetes mellitus (GDM) and nondiabetic controls. Methods: Twenty-two women with GDM, diagnosed according to the current criteria of the American Diabetes Association, were compared with 22 controls. Maternal and cord blood and placental samples were obtained from all pregnant women. Cord plasma EPO levels and NRBC counts, maternal and cord plasma MDA and VEGF levels were determined. Placental tissues were examined histologically. Results: Maternal and cord plasma levels of MDA and cord plasma EPO levels and NRBC counts were significantly higher in GDM pregnancies (p < 0.01). The presence of villous immaturity, chorangiosis and ischemia were significantly increased in the placentas of women with GDM (p < 0.05). The maternal and cord plasma levels of MDA increased (p = 0.007 and p = 0.001, respectively), whereas VEGF decreased (p = 0.046 and p = 0.001, respectively) with the presence of villous immaturity. Conclusion: The complex process of villous development and maturity might be influenced by the maternal and fetal oxidative and angiogenetic milieu. The placenta that shows abnormalities in angiogenesis and maturation may lead to fetal hypoxia and compromise.

show abstract

“…Numerous studies have revealed increased MDA and TBARS levels in maternal and cord blood as well as in placenta from pregnancies complicated by GDM (Tab. 1) [44][45][46][47][48][49][50][51][52][53][54][55][56][57]. Additionally, MDA level has been found to positively correlate with blood glucose concentration [40].…”

Section: Biomarkers Of Oxidative Damagementioning

confidence: 99%

“…tocopherol (vitamin E), ascorbate (vitamin C), and carotenoids (vitamin A), in GDM are both contradictory and confusing [44,50,54,55,[63][64][65][66][67][68][69].…”

Section: Endogenous Antioxidantsmentioning

confidence: 99%

Stres oksydacyjny indukowany hiperglikemią w cukrzycy ciążowej (GDM)

Turek

Woźniak

Cypryk

et al. 2015

Clinical Diabetology

View full text Add to dashboard Cite

show abstract

Lipid peroxidation and vitamin E status in gestational diabetes mellitus

Abstract: Gestational diabetes is not associated with increased levels of lipid peroxides and decreased levels of alpha-tocopherol.

Cited by 21 publications

References 22 publications

Antioxidant Vitamins and Lipoperoxidation in Non-pregnant, Pregnant, and Gestational Diabetic Women: Erythrocytes Osmotic Fragility Profiles

Antioxidant Vitamins and Lipoperoxidation in Non-pregnant, Pregnant, and Gestational Diabetic Women: Erythrocytes Osmotic Fragility Profiles

The Incidence of Placental Abnormalities, Maternal and Cord Plasma Malondialdehyde and Vascular Endothelial Growth Factor Levels in Women with Gestational Diabetes Mellitus and Nondiabetic Controls

Stres oksydacyjny indukowany hiperglikemią w cukrzycy ciążowej (GDM)

Contact Info

Product

Resources

About