Lipid peroxidation, antioxidant protection and aging

Abstract

The free radical hypothesis of aging proposes that deleterious actions of oxygen-derived radicals are responsible for the functional deterioration associated with aging. Because cellular membranes house the production apparatus of these radicals and because membranes suffer great damage from these radicals, modification of membrane lipids has been proposed to play a major role in the process of aging. Although the relationships between lipid peroxidation and aging have been investigated extensively, the studies have produced conflicting results. Increased lipid peroxidation and decreased antioxidant protection frequently occur, but they are not universal features of aging. Instead, age-dependent changes in these parameters appear to be species-, strain-, sex- and tissue specific. Potential correlations between lipid peroxidation and transition metal concentrations or between lipid peroxidation and declining antioxidant protection have been obscured by the contradictory nature of the findings. Future studies should focus on new approaches for the measurement in vivo lipid peroxidation and on identification of the critical targets of lipid peroxidation.

Effect of age on lipid peroxidation of fresh and frozen-thawed semen of Nili-Ravi buffalo bulls

“…However, based on the results, it appeared that overall lipid peroxidation in bull semen was independent of age. According to a previous study, increased lipid peroxidation is not a universal feature of aging (Rikans and Hornbrook 1997). In mammals, lipid peroxidation has been suggested to vary according to species, strain, sex and tissue (Rikans and Hornbrook 1997).…”

Age and sex-related changes in superoxide dismutase activity in bovine tissues

“…The age related changes and their intensity are different depending on the tissue (Rikans and Hornbrook 1997) due to the metabolic rate of particular tissue and the presence of different isoforms of enzymes. There are significant differences between pre-and post-mitotic tissues.…”

Resistance of erythrocytes from Brown trout (Salmo trutta m. trutta L.) affected by ulcerative dermal necrosis syndrome

“…The peroxidation process is subsequent to the consumption of intracellular antioxidants (Yagi 1993). The intracellular concentration of reactive oxygen species can be increased either by overproduction of ROS or by an inability of the metabolic system to destroy them (Rikans andHornbrook 1997, Limón-Pacheco andGonsebatt 2009). High level of lipid and protein peroxidation also appeared as potential marker of oxidative stress induced by UDN.…”