Lipid peroxidation in cord blood at birth

Wang, Wei; Pang, Calvin C P; Rogers, Michael S.; Chang, A.M.Z.

doi:10.1016/s0002-9378(96)70374-5

Cited by 56 publications

(47 citation statements)

References 24 publications

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“…Hydroperoxides are potentially toxic molecules capable of demolishing enzymes and cell membranes (Wang et al, 1996). The observed elevation in liver hydroperoxide level (Table 3) may be due to diminished activities of antioxidant enzymes which go in favour of an unrestrained production of free radicals and the subsequent production of lipid hydroperoxides (Matkovics et al, 1998).…”

Section: Groupsmentioning

confidence: 99%

Remnant B-cell-stimulative and anti-oxidant effects of <i>Persea americana</i> fruit extract studied in rats introduced into streptzotocin-induced hyperglycaemic state

Rao¹,

Adinew²

2011

Afr. J. Trad. Compl. Alt. Med.

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Insulin-stimulative and anti-oxidative effects of Persea americana fruit extract were evaluated using streptozotocin (STZ). Ethanol extract of P. americana in the concentration of 300 mg/kg body weight/rat /day was orally administered to rats introduced into STZ-induced hyperglycaemic state for a period of 30 days. After the treatment with avocado fruit extract, the elevated levels of blood glucose, glycosylated haemoglobin, blood urea and serum creatinine seen in the hyperglycaemic rats, reverted back to near normal. Similarly, significantly decreased plasma insulin and haemoglobin levels went back to near normal after the treatment, suggesting the insulin-stimulative effect of P. americana fruit. Determination of thiobarbituric acid reactive substances (TBARS), hydroperoxides and both enzymatic and non-enzymatic antioxidants, confirmed the anti-oxidative potential of avocado fruit extract which, in turn, might be responsible for its hypoglycaemic potential. Changes in activities of enzymes such as serum aspartate transaminase (AST), serum alanine transaminase (ALT), and serum alkaline phosphatase (ALP) seen in the control and experimental rats, revealed the tissue-protective nature of Persea americana fruits, while all of the analysed biochemical parameters were comparable to those obtained with gliclazide as a standard reference drug.

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Section: Groupsmentioning

confidence: 99%

Remnant B-cell-stimulative and anti-oxidant effects of <i>Persea americana</i> fruit extract studied in rats introduced into streptzotocin-induced hyperglycaemic state

Rao¹,

Adinew²

2011

Afr. J. Trad. Compl. Alt. Med.

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“…It has been observed that failure of maturation of antioxidant defence system in premature infants contributes to the onset and progression of bronchopulmonary dysplasia (2). Oxygen free radicals are highly reactive and are capable of damaging macromolecules like DNA, proteins, polyunsaturated fatty acids and carbohydrates (3,4,5,6,7). Polyunsaturated fatty acids upon peroxidation produce malondialdehyde.…”

Section: Introductionmentioning

confidence: 99%

Maternal and fetal indicators of oxidative stress during intrauterine growth retardation (IUGR)

Kamath

Rao

Kamath

et al. 2006

Indian J Clin Biochem

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The present study demonstrates the possibility of increased lipid peroxidation and protein oxidation in both maternal and fetal erythrocytes as markers of oxygen radical activity during intrauterine growth retardation. The erythrocyte MDA levels were significantly elevated in mothers of IUGR babies when compared to controls (p<0.01). The endogenous protein damage due to oxidative stress was significantly higher in IUGR mothers when compared to controls (p<0.05). Similarly the proteolytic activity in erythrocyte lysates against oxidatively damaged hemoglobin was significantly increased in mothers of IUGR babies compared to controls (p<0.001).In fetuses born with IUGR, both lipid peroxidation and proteolytic activity were significantly increased when compared to normal newborns (p<0.01).The result of this study indicates that oxidative stress was induced both in IUGR babies and their mothers which is manifested as increased lipid peroxidation and protein oxidant damage.

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“…Other authors found that spontaneous delivery caused the increase of LPX products levels in plasma of newborns in comparison to those delivered by caesarean section (Rogers et al 1998). According to some authors, TBARS could be used as a more sensitive indicator of foetal tissues injury caused by perinatal hypoxia than ABB parameters (Wang et al 1996;Rogers et al 1999).…”

Section: Resultsmentioning

confidence: 99%

“…Wang et al (1996) reported association between MDA levels and acid-base balance (ABB) parameters in umbilical cord blood, which reflected foetal tissue injury at birth. Moreover, according to Rogers et al (1998), TBARS might be a more sensitive indicator of foetal hypoxia than ABB parameters in umbilical cord blood.…”

Section: Introductionmentioning

confidence: 99%

Lipid peroxidation and biochemical parameters in maternal pre-delivery and post-delivery plasma

et al. 2010

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Lipid peroxidation (LPX) can play an important role in development of functional and pathological changes of maternal tissues in the course of pregnancy and delivery. LPX products were measured as thiobarbituric acid reacting substances (TBARS), using malondialdehyde as the standard solution. Actual TBARS determined in maternal post-delivery plasma (2.71 ± 0.602 nmol/mL) were not statistically different from those determined in pre-delivery plasma (3.45 ± 0.530 nmol/mL). TBARS production was measured in vitro in the both incubated plasma (30 min, 37• C) with and without the added LPX activator (125 µM L-ascorbate plus 5 µM FeSO4). A difference in the TBARS formation was found only in the post-delivery plasma, as a result of approximately twice higher (marginally significant) TBARS formation in the incubated plasma without the added LPX activator comparing with the actual TBARS levels in this plasma. These results suggest that changes in maternal tissues in the process of labour could create suitable conditions for activation of LPX in maternal plasma. On the other hand, all other analysed biochemical parameters (iron, total iron-binding capacity, uric acid, proteins, magnesium, calcium, phosphate, glucose, potassium, sodium, chlorides, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, creatine kinase, lactate dehydrogenase, α-hydroxybutyrate dehydrogenase, α-amylase, alkaline phosphatase, acid phosphatase in the post-delivery plasma were not different from those analysed in the pre-delivery plasma.

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Lipid peroxidation in cord blood at birth

Cited by 56 publications

References 24 publications

Remnant B-cell-stimulative and anti-oxidant effects of <i>Persea americana</i> fruit extract studied in rats introduced into streptzotocin-induced hyperglycaemic state

Remnant B-cell-stimulative and anti-oxidant effects of <i>Persea americana</i> fruit extract studied in rats introduced into streptzotocin-induced hyperglycaemic state

Maternal and fetal indicators of oxidative stress during intrauterine growth retardation (IUGR)

Lipid peroxidation and biochemical parameters in maternal pre-delivery and post-delivery plasma

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