Lipid peroxidation in relation to ageing and the role of endogenous aldehydes in diabetes and other age-related diseases

Dmitriev, L F; Титов, В. Н.

doi:10.1016/j.arr.2009.09.004

Cited by 77 publications

(46 citation statements)

References 96 publications

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“…Consequentemente, há perda da seletividade na troca iônica e liberação do conteúdo de organelas, como as enzimas hidrolíticas dos lisossomas, e formação de produtos citotóxicos (como o malondialdeído, MDA), culminando com a morte celular (Hershko, 1989). A lipoperoxidação também pode estar associada aos mecanismos de envelhecimento, de câncer e à exacerbação da toxicidade de xenobióticos (Shan et al, 1990;Dmitriev & Titov, 2010). Assim como na formação das ERO, nem sempre os processos de lipoperoxidação são prejudiciais, pois seus produtos são importantes na reação em cascata a partir do ácido araquidônico (formação de prostaglandinas) e, portanto, na resposta inflamatória (Halliwell & Gutteridge, 1990).…”

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Proteção do dano oxidativo hepático induzido por ferro pelo extrato aquoso da planta Plectranthus barbatus

Perandin

Maioli

Santos

et al. 2015

Rev. bras. plantas med.

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RESUMO:Plectranthus barbatus Andrews (Lamiaceae) é uma planta muita utilizada na medicina popular para o tratamento de doenças gastrointestinais e hepáticas. O objetivo do presente trabalho foi estudar o efeito protetor do extrato aquoso de P. barbatus (EAPB) sobre os danos hepáticos causados pela sobrecarga de ferro provocada pelo ferro-dextran em ratos. O tratamento com ferro-dextran induziu uma redução significativa na concentração de glutationa reduzida nos animais tratados em relação ao grupo controle e o tratamento prévio dos animais com o EAPB protegeu o fígado do efeito provocado pelo ferro neste parâmetro. Com relação à lipoperoxidação, houve aumento significativo na concentração de malondialdeído (MDA) nos animais tratados em relação ao controle, entretanto, quando os animais receberam o tratamento prévio com o EAPB, houve redução significativa na concentração do MDA. A análise histopatológica mostrou que o grupo tratado com ferro-dextran apresentou grânulos de ferro no citoplasma das células de Kupffer com alargamento das mesmas e algumas com os núcleos hipertróficos. O tratamento prévio com EAPB resultou no desaparecimento dos sinais de danos às células de Kupffer sem nenhum núcleo hipertrófico, mas com a presença de grânulos de ferro totalmente fagocitados, o que demonstra uma aparência morfológica normal. Portanto, o EAPB pode ser útil na prevenção de danos hepáticos induzidos por sobrecarga de ferro. Palavras-chave:Plectranthus barbatus, ferro, fígado, toxicidade, estresse oxidativo.ABSTRACT: Protection against hepatic oxidative damage induced by iron by the aqueous extract of Plectranthus barbatus. The Plectranthus barbatus Andrews (Lamiaceae) is a plant largely used in folk medicine to treat gastrointestinal and liver diseases. The objective of this work was to study the protective effect of the aqueous extract of P. barbatus (EAPB) against damage caused by iron overload induced by iron dextran in rat liver. Treatment with irondextran induced a significant reduction in the glutathione levels in treated animals compared to control group, and the pretreatment of animals with EAPB protected the liver from the effects caused by iron in this parameter. With respect to lipid peroxidation, a significant increase in the malondialdehyde (MDA) levels in treated animals compared to control was observed; however, when the animals were pretreated with EAPB, there was a significant reduction in the MDA levels. Histopathological analysis showed that the group treated with iron-dextran showed iron granules in the cytoplasm of the Kupffer cells and some of them presented enlarged nuclei. The group previously treated with EAPB showed the disappearance of the signs of damage to the Kupffer cells with no nucleus hypertrophy but with the presence of iron granules completely phagocytosed by these cells, which showed a normal morphological appearance. Therefore, the EAPB may be useful in the prevention of liver damage induced by iron overload.

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Proteção do dano oxidativo hepático induzido por ferro pelo extrato aquoso da planta Plectranthus barbatus

Perandin

Maioli

Santos

et al. 2015

Rev. bras. plantas med.

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“…SOD can scavenge O 2 − · whereas CAT is involved in the detoxification of H 2 O 2 , thus further preventing the formation of ·OH (Julie et al 1999). Manoldiadehyde (MDA) is among the main lipid peroxidation (LPO) metabolites (along with lipid hydroperoxides, n-hexanal, and conjugated dienes) and is considered to be a reliable indicator of oxidative damage of cellular membranes and therefore oxidative stress (Nigam et al 1999;Dmitriev and Titov 2010). Similarly, excessive nitric oxide (NO) production induces an increase in LPO, while NO reacts with O 2 − · to generate peroxynitrite, leading to further damage of cells (Snyder and Bredt 1992;Mak et al 2002).…”

Section: Introductionmentioning

confidence: 96%

In vivo antioxidative effect of isoquercitrin on cadmium-induced oxidative damage to mouse liver and kidney

Yuan

Dong

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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Cadmium (Cd) is an environmental pollutant and has been found to pose a potential threat to human health. Isoquercitrin (IQ) is one of the most important flavonoids and has been demonstrated to exhibit potent antioxidant effects on plants and yeast cells. However, only few studies have investigated the antioxidative activities of reactive oxygen species (ROS) and the nitrite scavenging activities of IQ against Cd-induced oxidation in mouse. The present work was to investigate the ROS and nitrite-scavenging activities of IQ in vitro as well as its preventive effects against lipid peroxidation and protein oxidative damage in liver and kidney of mouse induced by Cd(²+) using spectrophotometry. Our results showed that IQ possesses scavenging abilities for superoxide anion, hydroxyl radical and nitrite. Such scavenging capacities increase with the concentration of IQ. Moreover, cadmium chloride (CdCl₂ (2.5 mg/kg body weight, i.p. CdCl₂) significantly inhibited the activities of superoxide dismutase and catalase and raised the levels of malondialdehyde, nitric oxide, protein carbonyl, and the coefficients of DNA-protein crosslinks in livers and/or kidneys of mice. IQ attenuated the Cd(²+)-induced biochemical alterations in the livers and/or kidneys of mice, indicating that the formation of ROS and nitrite is possibly reduced. Our work demonstrates that IQ possesses ROS and nitrite-scavenging capacities and plays a significant role in combating Cd(²+)-induced toxicity in animals.

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“…The pharmacological action of D-tocopherol is not only as a natural antioxidant but also as a preventive against cancer [4]. Moreover, vitamin E is also used in cosmetology as an anti-aging agent [5].So far, high-proficiency extraction of D-tocopherol in extracts of M. alterniflorum has not been reported. Therefore, the objective of this work is the development of 1 an extraction protocol allowing the best conservation (conformation stability, evaporation) of D-tocopherol from chlorophyllian organs and 2 a high-performance liquid chromatography (HPLC) method for accurate value measurement to predict if the alternate watermilfoil could represent an interesting source of natural D-tocopherol for pharmaceutical and cosmetic applications.…”

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confidence: 99%

mentioning

confidence: 99%

HPLC method for the analysis of α-tocopherol from Myriophyllum alterniflorum

Delmail

Buzier²,

Simon³

et al. 2011

Chem Nat Compd

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Lipid peroxidation in relation to ageing and the role of endogenous aldehydes in diabetes and other age-related diseases

Cited by 77 publications

References 96 publications

Proteção do dano oxidativo hepático induzido por ferro pelo extrato aquoso da planta Plectranthus barbatus

Proteção do dano oxidativo hepático induzido por ferro pelo extrato aquoso da planta Plectranthus barbatus

In vivo antioxidative effect of isoquercitrin on cadmium-induced oxidative damage to mouse liver and kidney

HPLC method for the analysis of α-tocopherol from Myriophyllum alterniflorum

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