Lipid peroxidation in the heart of adult and old rats during immobilization stress

Davydov, Roman; Shvets, V. N.

doi:10.1016/s0531-5565(01)00086-9

Cited by 25 publications

(11 citation statements)

References 9 publications

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“…This assay is the easiest method used to study the effects of different treatments on lipid peroxidation and can be applied to crude biological extracts. Although its specificity has been questioned (26), this particular assay is widely used for ex vivo and in vitro measurements (2,3,21,22,27,28) and is accepted as an empirical window for the examination of the complex process of lipid peroxidation (26).…”

Section: Discussionmentioning

confidence: 99%

Lipid peroxidation and total radical-trapping potential of the lungs of rats submitted to chronic and sub-chronic stress

Torres

Gamaro

et al. 2004

Braz J Med Biol Res

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Exposure to stress induces a cluster of physiological and behavioral changes in an effort to maintain the homeostasis of the organism. Long-term exposure to stress, however, has detrimental effects on several cell functions such as the impairment of antioxidant defenses leading to oxidative damage. Oxidative stress is a central feature of many diseases. The lungs are particularly susceptible to lesions by free radicals and pulmonary antioxidant defenses are extensively distributed and include both enzymatic and non-enzymatic systems. The aim of the present study was to determine lipid peroxidation and total radical-trapping potential (TRAP) changes in lungs of rats submitted to different models of chronic stress. Adult male Wistar rats weighing 180-230 g were submitted to different stressors (variable stress, N = 7) or repeated restraint stress for 15 (N = 10) or 40 days (N = 6) and compared to control groups (N = 10 each). Lipid peroxidation levels were assessed by thiobarbituric acid reactive substances (TBARS), and TRAP was measured by the decrease in luminescence using the 2-2'-azo-bis(2-amidinopropane)-luminol system. Chronic variable stress induced a 51% increase in oxidative stress in lungs (control group: 0.037 ± 0.002; variable stress: 0.056 ± 0.007, P < 0.01). No difference in TBARS was observed after chronic restraint stress, but a significant 57% increase in TRAP was presented by the group repeatedly restrained for 15 days (control group: 2.48 ± 0.42; stressed: 3.65 ± 0.16, P < 0.05). We conclude that different stressors induce different effects on the oxidative status of the organism.

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Section: Discussionmentioning

confidence: 99%

Lipid peroxidation and total radical-trapping potential of the lungs of rats submitted to chronic and sub-chronic stress

Torres

Gamaro

et al. 2004

Braz J Med Biol Res

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“…Aged rat brains had considerably increased accumulation of end-products compared to those from young animals 66 . Davydov and Shvets analysed lipid peroxidation products, with LFP being one of them, in the heart of adult and old rats exposed to stress to assess whether myocardium becomes less resistant against stress at old age 67 . LFP were also measured in brain of rats exposed to lead in order to investigate the possible mechanism of lead toxicity and its role in oxidative stress in brain 68 .…”

Section: Lfp As Markers Of Oxidative Stress In Model Systemsmentioning

confidence: 99%

Lipophilic fluorescent products of free radicals

Ivica¹,

Wilhelm²

2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Stress plays an important role in the occurrence of these diseases [4,5]. The stimulation of free radical processes serves as an important part of the pathogenesis of stress damage of the visceral organs [3,6,7]. Such stimulation is followed by accumulation of a large number of carbonyl products, especially aldehydes in the cells [8,9].…”

Section: Introductionmentioning

confidence: 99%

Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats

Davydov¹

2014

AJBLS

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Resistance of the organism to the stress injury changes during ontogenesis. In this regard, the incidence of cardiovascular, central nervous, endocrine systems, etc. increases at certain stages of individual development. Taking into account the fact that the development of stress-caused lesions is associated with accumulation of carbonyl products of free radical oxidation in cells, we have suggested that the one of the reasons for this phenomenon is age-related changes in the efficiency of the scavenging of endogenous aldehydes in the organism. In view of this fact, spectrum of aldo-keto reductases in blood serum of rats at different stages of ontogenesis was investigated by means of electrophoresis. Identical changes in the composition of aldo-keto reductases spectrum of blood in early immature age and in aging have been shown. Change in aldo-keto reductases spectrum modulates the role of reductive pathway of endogenous aldehydes scavenging in the organism. Thus, in child age and aging efficiency of scavenging of carbonyl products of free radical oxidation in cells is limited and especially when they are intensively produced. This results in increase of the susceptibility of the organism to oxidative stress.

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Lipid peroxidation in the heart of adult and old rats during immobilization stress

Cited by 25 publications

References 9 publications

Lipid peroxidation and total radical-trapping potential of the lungs of rats submitted to chronic and sub-chronic stress

Lipid peroxidation and total radical-trapping potential of the lungs of rats submitted to chronic and sub-chronic stress

Lipophilic fluorescent products of free radicals

Age-Dependent Change in Aldo-Keto Reductases Composition in the Blood of Rats

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