Lipid Peroxidation in the Pancreas and Other Organs in Streptozotocin Diabetic Rats

Tatsuki, R; Satoh, Kumi; Yamamoto, Akira; Hoshi, Katsuji; Ichihara, Kazuo

doi:10.1254/jjp.75.267

Cited by 43 publications

(40 citation statements)

References 25 publications

(4 reference statements)

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“…Streptozotocin (STZ), an antibiotic produced by Streptomyces achromogenes, is the most widely used agent in experimental diabetes (9,10). This agent has been used for induction of diabetes in animals as a model of insulin-dependent diabetes mellitus (Type 1 diabetes mellitus) (9).…”

Section: Introductionmentioning

confidence: 99%

“…This agent has been used for induction of diabetes in animals as a model of insulin-dependent diabetes mellitus (Type 1 diabetes mellitus) (9). Many actions have been attributed to STZ that are including damage to the pancreatic β-cell membrane and decreases insulin secretion from the β-cell.…”

Section: Introductionmentioning

confidence: 99%

“…Many actions have been attributed to STZ that are including damage to the pancreatic β-cell membrane and decreases insulin secretion from the β-cell. In addition, STZ has been shown to induce DNA strand breaks and methylation in pancreatic islet cells (9,11,12).…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative effects of aminoguanidine on rat aorta in Streptozotocin-induced diabetes and evaluation of α-SMA expression

Elbe¹,

Vardı²,

Orman³

et al. 2014

Anadolu Kardiyol Derg

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Objective: Diabetes mellitus is one of the chronic metabolic diseases which is characterized by microvascular and macrovascular complications. This study was designed to investigate the improving the effects of amnioguanidine on aortic damage in a streptozotocin (STZ) induced diabetic rat model. Methods: Thirty-two male Sprague-Dawley rats divided into four groups as follows: Control, Aminoguanidine, Diabetes, and Diabetes+Aminoguanidine. Experimental diabetes was induced by single dose STZ (45 mg/kg) intraperitoneally. After administration of STZ, the DM+AMG group began to receive AMG (1 g/L) was prepared by dissolving in tap water during 10 weeks. At the end of the study, blood glucose levels were determined and rats were sacrified by ketamine anesthesia. Following routine tissue process, aortas were embedded in paraffin. Histochemical (H-E and Orcein) and immunohistochemical α-smooth muscle actin (α-SMA) stains were applied and the sections examined by light microscope. Statistical analysis was carried out using the SPSS 13.0 statistical program. Results: The rats in diabetes group had significantly higher blood glucose levels than the rats of control. The main histological alterations were detected in tunica media such as extensive thickening (414.32±9.62 μm), irregular of elastic fibers and intensive α-SMA staining in diabetic rats. The thickness of tunica media was statistically increased in DM group, when compared with the control group (p<0.001). On the other hand, AMG prevented disorganization of elastic fibers and overexpression of α-SMA. The mean thickness of tunica media was decreased significantly in DM+AMG (319.16±6.53 μm) compared with the DM group (p<0.001).Conclusion: Our results demonstrate that AMG treatment may protect the impairment of aort structure at histological level.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ameliorative effects of aminoguanidine on rat aorta in Streptozotocin-induced diabetes and evaluation of α-SMA expression

Elbe¹,

Vardı²,

Orman³

et al. 2014

Anadolu Kardiyol Derg

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“…There is also considerable evidence that oxidative damage is increased in diabetes, though the mechanisms are not clear [2,3].…”

mentioning

confidence: 99%

Effect of Ethanolic Extract of Embelia Ribes on Dyslipidemia in Diabetic Rats

Bhandari

Kanojia

Pillai

2002

Journal of Diabetes Research

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Diabetes mellitus has been treated orally with herbal remedies based on folk medicine since ancient times. Embelia ribes burm (Myrsinaceae), known commonly as vidanga, was used in Ayurveda for its anthelmintic activity. Ayurveda describes vidanga as pungent, causes increase in digestive fire, and cures flatulence and colic. A single study reported the antihyperglycemic activity of decoction of E. ribes in glucose-induced hyperglycemic albino rabbits. In the present study, the lipid-lowering and antioxidant potential of ethanolic extract of E. ribes burm was investigated in streptozotocin (40 mg/kg, IV, single injection)-induced diabetes in rats. Twenty days of orally feeding the extract (200 mg/kg) to diabetic rats resulted in significant ( P < 0.01) decrease in blood glucose, serum total cholesterol, and triglycerides, and increase in HDLcholesterol levels when compared to pathogenic diabetic rats. Further, the extract also lowered the liver and pancreas thiobarbituric acid-reactive substances (TBARSs) values ( P < 0.01) when compared to TBARS values of liver and pancreas of pathogenic diabetic rats. The results of test drug were comparable to gliclazide (25 mg/kg, orally), a standard antihyperglycemic agent. This is the first pilot study to provide biochemical evidence of potential of E. ribes in diabetic dyslipidemia. Keywords Diabetes; Dyslipidemia; Embelia ribes; Lipid Peroxidation; StreptozotocinAccording to the Framingham Heart Study [1], dyslipidemia, which can range from hypercholesterolemia to hyperlipoproteinemia, is one of the many modifiable risk factors for coronary artery disease (CAD), stroke, and peripheral vascular disease. In diabetic dyslipidemia, lipid abnormalities may be the result of unbalanced metabolic states of diabetes (i.e., hyperglycemia and insulin resistance).

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“…Oxidative stress is caused by highly toxic components, such as the overproduction of reactive nitrogen and oxygen radicals which interact with the lipid bilayer and produce lipid peroxides of cellular membranes and caused toxicity to all the components of the cells (Tatsuki et al, 1997). Higher oxidative stress is one of the factors for impaired antioxidant defense mechanisms or increased levels of free radicals because it is implicated in the progression and development of diabetic complications (Ceriello, 2000;Saxena et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Effect of quercetin nanoparticles on the kidney of the streptozotocin-induced diabetes in male rats: A histological study and serum biochemical alterations

Al-Jameel¹,

El-Rahman²

2017

Afr. J. Biotechnol.

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Lipid Peroxidation in the Pancreas and Other Organs in Streptozotocin Diabetic Rats

Cited by 43 publications

References 25 publications

Ameliorative effects of aminoguanidine on rat aorta in Streptozotocin-induced diabetes and evaluation of α-SMA expression

Ameliorative effects of aminoguanidine on rat aorta in Streptozotocin-induced diabetes and evaluation of α-SMA expression

Effect of Ethanolic Extract of Embelia Ribes on Dyslipidemia in Diabetic Rats

Effect of quercetin nanoparticles on the kidney of the streptozotocin-induced diabetes in male rats: A histological study and serum biochemical alterations

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