Lipid peroxidation products as predictors of oxidant-mediated disease in preterm infants

Katti, Karishma; Ayasolla, Kamesh; Iurcotta, Toni; Potak, Debra; Codipilly, Champa N; Weinberger, Barry

doi:10.1080/14767058.2020.1869934

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…Clinical studies have shown that preterm birth, low birth weight, growth restriction and developmental malformations are associated with lipid peroxidation in the fetus [ 49 , 53 ]. At birth, preterm infants have been reported to have higher levels of lipid peroxidation than full-term infants, as revealed by higher plasma MDA and presence of lipid peroxides [ 54 , 55 ]. These observations suggest that accumulation of lipid peroxides is a risk for preterm birth.…”

Section: Discussionmentioning

confidence: 99%

Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development

Niu

Wan

et al. 2022

Redox Biology

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Section: Discussionmentioning

confidence: 99%

Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development

Niu

Wan

et al. 2022

Redox Biology

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“…The preterm infants were susceptible to oxygen radical disease and it can treat with antioxidant therapy in which the well-known antioxidant nutrient vitamin E can be used to treat this condition in preterm infants [78]. The formula fed preterm infants have the risk of developing high oxidative stress but in the study with 31 healthy preterm infants shows that long chain poly unsaturated fatty acid supplemented group does not affect the solubility of and -tocopherol [79].…”

Section: Discussionmentioning

confidence: 99%

Role of Vitamin E in Boosting the Immunity from Neonates to Elderly

Kowsalya¹,

Rajeshkumar²,

Velmurugan³

et al. 2021

Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects

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The vitamin E is a fat-soluble vitamin which occurs as a tocopherol component abundant in humans. The vitamin E supplements in humans and animals have provided numerous health benefits. The vitamin E is rich in antioxidants which slow the aging process and reduce the free radical damage. Vitamin E isoforms play an important role in respiratory health. It is also important in health and well-being of preterm neonates. Vitamin E deficiency in new born includes hemolytic anemia, disease of retina, bronchopulmonary dysplasia. Further, in vitro studies, vitamin E has increased the oxidative resistance and prevents the atherosclerotic plaque. The consumption of vitamin E rich foods reduces coronary heart diseases. This chapter focuses on the treatment of vitamin E deficiency in preterm babies and the role of vitamin E in preventing coronary heart diseases.

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“…Postnatal 8-isoprostane levels have also been evaluated by Ahola et al in extremely low birth weight neonates, showing significantly higher levels on day 3 and 7 in infants with severe IVH compared to no IVH, and on day 7 in infants who developed PVL compared to those who did not [ 82 ]. In a similar fashion, increased 8-isoprostane levels were observed within the first 48 h in preterm infants with oxygen radical diseases, including IVH/PVL [ 78 ]; however, as per MDA, these conditions were not assessed separately from the other diseases.…”

Section: Free Radical Biomarkers In Neonatal Brain Injurymentioning

confidence: 98%

“…With regard to prematurity-related brain injury, a significant increase in the concentration of plasma MDA was reported during the first 12 h of life in association with IVH development [ 76 ], whereas the evaluation of urine MDA in preterm infants developing oxygen radical diseases, including IVH/PVL, has led to controversial results [ 77 , 78 ]. In these latter studies, however, the specific correlation between MDA levels and prematurity-related brain lesions, however, was not investigated.…”

Section: Free Radical Biomarkers In Neonatal Brain Injurymentioning

confidence: 99%

Free Radicals and Neonatal Brain Injury: From Underlying Pathophysiology to Antioxidant Treatment Perspectives

et al. 2021

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Free radicals play a role of paramount importance in the development of neonatal brain injury. Depending on the pathophysiological mechanisms underlying free radical overproduction and upon specific neonatal characteristics, such as the GA-dependent maturation of antioxidant defenses and of cerebrovascular autoregulation, different profiles of injury have been identified. The growing evidence on the detrimental effects of free radicals on the brain tissue has led to discover not only potential biomarkers for oxidative damage, but also possible neuroprotective therapeutic approaches targeting oxidative stress. While a more extensive validation of free radical biomarkers is required before considering their use in routine neonatal practice, two important treatments endowed with antioxidant properties, such as therapeutic hypothermia and magnesium sulfate, have become part of the standard of care to reduce the risk of neonatal brain injury, and other promising therapeutic strategies are being tested in clinical trials. The implementation of currently available evidence is crucial to optimize neonatal neuroprotection and to develop individualized diagnostic and therapeutic approaches addressing oxidative brain injury, with the final aim of improving the neurological outcome of this population.

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Lipid peroxidation products as predictors of oxidant-mediated disease in preterm infants

Cited by 7 publications

References 24 publications

Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development

Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development

Role of Vitamin E in Boosting the Immunity from Neonates to Elderly

Free Radicals and Neonatal Brain Injury: From Underlying Pathophysiology to Antioxidant Treatment Perspectives

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