Lipid peroxidation the levels of antioxidant enzymes in hypertension

Amanullah, Mohammad; Zaman, Gaffar Sarwar; Rahman, Jalelur; Rahman, Sajida

doi:10.5530/ax.2012.2.2.3

Cited by 7 publications

(4 citation statements)

References 56 publications

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“…Plasma activity of SOD, CAT and GPx in moderate hypertensive patients was significantly reduced than that of normotensive subjects, there is a further significant reduction p<0.05 in the activity of these molecules from moderate to severe hypertensive patients showing a possible association between these parameters and hypertension progression. Similar finding was reported by previous research which support the result of this work [18]. The reported decrease in activity of antioxidant enzymes in these patients could be due to poor nutritional status and increased production of free radicals as a result of high blood pressure.…”

Section: Discussionsupporting

confidence: 93%

Plasma Activity of Antioxidants and Lipid Peroxidation Level Among Patients having Moderate and Severe Hypertension

Akinlua¹

2021

J Clin Med Res

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Hypertension or high blood pressure and its complications is a major cause of morbidity and mortality all over the world. The development of hypertension has been linked to atherosclerosis formation and progression which in turn has its root in free radicals induced oxidative stress and antioxidants present. This work was undertaken to determine plasma activity of enzymatic antioxidants and lipid peroxidation level in patients with moderate and severe hypertension to establish a possible association between these parameters and progression of hypertension. A total number of 60 hypertensive patients that are freshly diagnosed made up of 30 moderate and 30 severe hypertensive patients with 30 relatively healthy subjects as control recruited from Wesley Guide Hospital, Ilesa, Osun State Nigeria was used for this study. Plasma activity of catalase, superoxide dismutase, glutathione peroxidase and plasma level of malondialdehyde (MDA) was determined in both patients and control subjects using standard methodologies. The results obtained was subjected to statistical analysis using two-way analysis of variance (ANOVA) and post-hoc Duncan test with (p<0.05) considered to be significant. The result of this study revealed a significant decrease (P<0.05) in the activity of the antioxidant enzymes considered. The plasma MDA in all the patients was raised but not statistically significant p<0.05 from result obtained for the control subjects. Progressive decrease in the activity of antioxidant enzymes in these patients and a possible oxidative stress as hypertension progresses as shown in this study could be a pointer to the fact that these molecules might influence greatly the progression of hypertension.

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Section: Discussionsupporting

confidence: 93%

Plasma Activity of Antioxidants and Lipid Peroxidation Level Among Patients having Moderate and Severe Hypertension

Akinlua¹

2021

J Clin Med Res

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“…Furthermore, increase in oxidative stress may damage the endothelium and impair endothelium-dependent vasodilatation, consequently increasing vascular contractile activity [69]. ROS may also induce endothelial permeability with the recruitment of inflammatory protein and cells, in which can compromise endothelial function and worsen vascular damage [70]. All these observed effects on the vasculature further support the pathological role of oxidative stress in hypertension.…”

Section: Pathogenesis Of Hypertensionmentioning

confidence: 99%

“…Amanullah et al [70] reported that higher MDA levels and lower antioxidant activities such as SOD, GSH, and GPx in hypertensive subjects may be due to increased production of free radicals, indicating the presence of oxidative stress in hypertension. There were notable a positive correlation between BP and lipid peroxidation products in the hypertensives and a negative correlations between BP with plasma antioxidant capacity, plasma vitamin C levels, erythrocyte activity of antioxidant enzymes, and erythrocyte reduced/oxidized glutathione (GSH/GSSG) ratio [71].…”

Section: Pathogenesis Of Hypertensionmentioning

confidence: 99%

Nigella sativaand Its Protective Role in Oxidative Stress and Hypertension

Leong

Mustafa

Jaarin

2013

Evidence-Based Complementary and Alternative Medicine

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Hypertension increases the risk for a variety of cardiovascular diseases, including stroke, coronary artery disease, heart failure, and peripheral vascular disease. The increase in oxidative stress has been associated with the pathogenesis of hypertension. Increase of blood pressure is due to an imbalance between antioxidants defence mechanisms and free radical productions. Excessive production of reactive oxygen species reduces nitric oxide bioavailability leading to an endothelial dysfunction and a subsequent increase in total peripheral resistance. Hypertension can cause few symptoms until it reaches the advanced stage and poses serious health problems with lifelong consequences. Hypertensive patients are required to take drugs for life to control the hypertension and prevent complications. Some of these drugs are expensive and may have adverse reactions. Hence, it is timely to examine scientifically, complimentary therapies that are more effective and with minimal undesirable effects. Nigella sativa (NS) and its active constituents have been documented to exhibit antioxidant, hypotensive, calcium channel blockade and diuretic properties which may contribute to reduce blood pressure. This suggests a potential role of NS in the management of hypertension, and thus more studies should be conducted to evaluate its effectiveness.

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“…GPx reduces lipidic or nonlipidic hydroperoxides as well as H 2 0 2 while oxidizing two molecules of GSH (Amanullah et al . ). Thus, we postulate that the elevated GPx activity at highest exposure dose was a response to the generation of excess lipid hydroperoxide radicals.…”

Section: Discussionmentioning

confidence: 97%

Effects of selenium on oxidative damage and antioxidant enzymes of eukaryotic cells: wine Saccharomyces cerevisiae

et al. 2018

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Aim: To clarify the effects of selenium (Se), parameters related to oxidative issues, as well as the antioxidant response were investigated on an autochthonous wine yeast strain. Methods and Results: Antioxidant enzyme activity, gel electrophoresis, Western blot and MDA level were used to investigate the effects of different concentration of Se in wine yeast. We found that Se is able to affect the enzymatic activities of catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD). An increase in lipid peroxidation was observed in a dose-dependent manner of (Se), thus, indicating the occurrence of cell membrane damage. Additionally, Se induced post-translational oxidative modifications of proteins, especially oxidation of thiol groups (both reversible and irreversible) and protein carbonylation (irreversible oxidation). Conclusion: These results obtained could further the understanding the effect of different concentration of Se in wine yeast strain with which Se affect the enzymatic activities and induces some post-translational modifications of proteins. Significance and Impact of the Study: The understanding of mechanisms regulating the response of wine yeast to Se is important for future work using selenized yeast as enriched Se supplements in human nutrition.

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Lipid peroxidation the levels of antioxidant enzymes in hypertension

Cited by 7 publications

References 56 publications

Plasma Activity of Antioxidants and Lipid Peroxidation Level Among Patients having Moderate and Severe Hypertension

Plasma Activity of Antioxidants and Lipid Peroxidation Level Among Patients having Moderate and Severe Hypertension

Nigella sativaand Its Protective Role in Oxidative Stress and Hypertension

Effects of selenium on oxidative damage and antioxidant enzymes of eukaryotic cells: wine Saccharomyces cerevisiae

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