Lipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levels

Yeşilbursa, Dilek; Serdar, Zehra Aşiran; Serdar, Akýn; Saraç, Murat; Coşkun, Şenol; Jale, C

doi:10.1038/sj.ijo.0802794

Cited by 91 publications

(59 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown that circulating MDA levels are higher in diabetic and obese subjects than in non-obese healthy controls (Prazny, Skrha, & Hilgertova, 1999). A reduction of fasting blood glucose levels as well as MDA levels have been previously reported to accompany weight loss in obese subjects (Yesilbursa, Serdar, Sarac, & Jale, 2005). The decrease in plasma MDA concentration observed in the current trial suggests that the whole process of lipid peroxidation was diminished by regular consumption of DG.…”

Section: Discussionsupporting

confidence: 62%

Effectiveness of Dichrostachys glomerata Spice Phenolics in Reduction of Oxidative Stress Associated with Obesity and Type 2 Diabetes; a Randomized, Double-Blind Placebo-Controlled Clinical Trial

Kuate¹,

Kengne²,

Dakam³

et al. 2013

JFR

View full text Add to dashboard Cite

This work evaluated the effect of Dichrostachys glomerata on the improvement of antioxidant biomarkers in obesity and type 2 diabetes participants, in an eight-week randomized, double-blind, placebo-controlled design study. The active (400 mg) or placebo formulation were administered twice daily throughout the study period to two normoglycemic and two diabetic obese random groups. Plasma levels of a total of 8 biochemical parameters were taken at the baseline and after 4 and 8 weeks of treatment. No differences in urate variation were observed while the plasma phenolic content as well as the reduced glutathione level, ascorbate concentration, FRAP value and enzymatic antioxidant activities significantly increased with a concomitant reduction of MDA after 8 weeks compared to placebo (P < 0.01). On the contrary to urate and ascorbate, plasma polyphenol content correlated well with FRAP level in both treated groups indicating that phenolics from the spice greatly contributed to the antioxidant activity.

show abstract

Section: Discussionsupporting

confidence: 62%

Effectiveness of Dichrostachys glomerata Spice Phenolics in Reduction of Oxidative Stress Associated with Obesity and Type 2 Diabetes; a Randomized, Double-Blind Placebo-Controlled Clinical Trial

Kuate¹,

Kengne²,

Dakam³

et al. 2013

JFR

View full text Add to dashboard Cite

show abstract

“…26 However, the risk appeared to decline after bariatric surgery, since LPO in the post-surgical obese group was lower than in the pre-surgical obese group. This result may be explained by the decline in body weight presented by the patients since, according to Yesilbursa,27 weight loss is accompanied by reduced ROS production and decreased MDA levels. These findings corroborate the study by Valezi et al, 28 who assessed oxidative stress indicators in obese patients before and after Roux-en-Y gastric bypass.…”

Section: Figurementioning

confidence: 97%

Obesity, bariatric surgery and oxidative stress

Horn

Gelatti

Mori

et al. 2017

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

Introduction: Obesity refers to the accumulation of fatty tissues and it favors the occurrence of oxidative stress. Alternatives that can contribute to body weight reduction have been investigated in order to reduce the production of reactive oxygen species responsible for tissue damage. The aim of the current study was to assess whether the oxidant and antioxidant markers of obese women before and after bariatric surgery were able to reduce oxidative damage. Method:We have assessed 16 morbidly obese women five days before and 180 days after the surgery. The control group comprised 16 non-obese women. Levels of thiobarbituric acid-reactive substances, carbonylated proteins, reduced glutathione and ascorbic acid were assessed in the patients' plasma. Results: Levels of lipid peroxidation and protein carbonylation in the pre-surgical obese women were higher than those of the controls and post-surgical obese women. Levels of reduced glutathione in the pre-surgical obese women were high compared to the controls, and declined after surgery. Levels of ascorbic acid fell in the pre--surgical obese women compared to the control and post-surgical obese women. Conclusion: Body weight influences the production of reactive oxygen species. Bariatric surgery, combined with weight loss and vitamin supplementation, reduces cellular oxidation, thus reducing tissue damage.

show abstract

“…The effects of Orlistat treatment on lipid peroxide levels were examined in a sample of nondiabetic obese men and women. 46 All subjects took 120 mg of Orlistat three times daily; no other lifestyle changes were implemented. After 6 months of treatment, the mean body weight of the obese group was reduced from 91.579.…”

Section: Obesity and Evidence Of Oxidant Stress In Humansmentioning

confidence: 99%

Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

2005

View full text Add to dashboard Cite

Objective: Oxidative stress may be the unifying mechanism underlying the development of comorbidities in obesity. Evidence suggests that a clustering of sources of oxidative stress exists in obesity: hyperglycemia, hyperleptinemia, increased tissue lipid levels, inadequate antioxidant defenses, increased rates of free radical formation, enzymatic sources within the endothelium, and chronic inflammation. Method: This review provides a summary of the available evidence on systemic oxidative stress in humans and specific metabolic pathways by which obesity may elevate systemic oxidant stress. The authors suggest possible methods of reducing oxidative stress such as antioxidant supplementation, caloric restriction and/or physical activity and surgical intervention to combat free radicals and reduce adipose tissue. Results: Obesity is associated with oxidative stress and can be reduced with weight loss (regardless of exercise or surgery induced weight loss), caloric restriction or antioxidant rich diets. Conclusion: Oxidative stress levels are elevated in human obesity, and these levels are modifiable with various lifestyle modifications and surgical interventions.

show abstract

Lipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levels

Cited by 91 publications

References 27 publications

Effectiveness of Dichrostachys glomerata Spice Phenolics in Reduction of Oxidative Stress Associated with Obesity and Type 2 Diabetes; a Randomized, Double-Blind Placebo-Controlled Clinical Trial

Effectiveness of Dichrostachys glomerata Spice Phenolics in Reduction of Oxidative Stress Associated with Obesity and Type 2 Diabetes; a Randomized, Double-Blind Placebo-Controlled Clinical Trial

Obesity, bariatric surgery and oxidative stress

Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

Contact Info

Product

Resources

About