Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair

Souto, Eliana B.; Yoshida, Cristiana Maria Pedroso; Leonardi, Gislaine Ricci; Cano, Amanda; Zielińska, Aleksandra; Viseras, César; Severino, Patrícia; Silva, Classius Ferreira da; Barbosa, Raquel de Melo

doi:10.3390/pharmaceutics13081199

Cited by 17 publications

(14 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lipids perform essential biological functions within the body, as a source of energy, as structural components of cell membrane, and as signaling molecules; their composition is associated with dietary fatty acid consumption. In the context of wound healing, lipids provide energy to the wound repair; they are responsible for providing substrates from lipids for wound cell proliferation and remodeling, highlighting that the consumption of adequate lipids is essential to the wound healing process [ 17 ]. In addition, lipids act as signaling agents during wound healing and tissue regeneration.…”

Section: Treatments For Topical Infected Woundsmentioning

confidence: 99%

“…Considering topical skin preparations that are commercially available, frequently they show the same limitations to impair wound healing, such as toxicity, drug instability, and a limited time of action [ 81 ]. Recently, topical forms containing nanostructured lipid carriers ( Figure 4 ) represent a strategy to develop new products for wound care, mainly drug delivery systems, dressings, and films [ 17 ]. Considering the healing, antimicrobial, and anti-inflammatory properties of lipids, added to their solubility, stability, and plasticizing action, the lipids into formulations increase skin penetration and release the profile of the drugs, improving wound healing therapies compared with conventional treatments [ 66 ].…”

Section: Treatments For Topical Infected Woundsmentioning

confidence: 99%

“…Different protein-based tools, for example nanostructures, blends, isolated biopolymers, or immobilizing systems, have been studied due to their essential interactions for the healing process [ 11 ]. The development of natural lipid-based topical formulations also represents an interesting strategy to manage the wound healing process due to their plasticizing, anti-aging, healing, antimicrobial, anti-inflammatory, and remodeling properties [ 17 ].…”

Section: Introduction To Wound Healingmentioning

confidence: 99%

See 2 more Smart Citations

The Use of Proteins, Lipids, and Carbohydrates in the Management of Wounds

et al. 2023

View full text Add to dashboard Cite

Despite the fact that skin has a stronger potential to regenerate than other tissues, wounds have become a serious healthcare issue. Much effort has been focused on developing efficient therapeutical approaches, especially biological ones. This paper presents a comprehensive review on the wound healing process, the classification of wounds, and the particular characteristics of each phase of the repair process. We also highlight characteristics of the normal process and those involved in impaired wound healing, specifically in the case of infected wounds. The treatments discussed here include proteins, lipids, and carbohydrates. Proteins are important actors mediating interactions between cells and between them and the extracellular matrix, which are essential interactions for the healing process. Different strategies involving biopolymers, blends, nanotools, and immobilizing systems have been studied against infected wounds. Lipids of animal, mineral, and mainly vegetable origin have been used in the development of topical biocompatible formulations, since their healing, antimicrobial, and anti-inflammatory properties are interesting for wound healing. Vegetable oils, polymeric films, lipid nanoparticles, and lipid-based drug delivery systems have been reported as promising approaches in managing skin wounds. Carbohydrate-based formulations as blends, hydrogels, and nanocomposites, have also been reported as promising healing, antimicrobial, and modulatory agents for wound management.

show abstract

Section: Treatments For Topical Infected Woundsmentioning

confidence: 99%

Section: Treatments For Topical Infected Woundsmentioning

confidence: 99%

Section: Introduction To Wound Healingmentioning

confidence: 99%

See 1 more Smart Citation

The Use of Proteins, Lipids, and Carbohydrates in the Management of Wounds

et al. 2023

View full text Add to dashboard Cite

show abstract

“…At present, most of the wound dressings available are unable to solve the problems related to chronic wounds, like bacterial resistance, protein adsorption, and increased levels of exudates. The biological properties of therapeutic dressings are related not only to the drugs used, but also to the presence of polymers or clay or lipid nanoparticles that can improve tissue repair, reducing the local inflammatory response more efficiently [ 4 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations

et al. 2022

Self Cite

View full text Add to dashboard Cite

Nanocomposites formed by clay and lipid carriers (NLCs) show a high potential for providing controlled release and specific delivery of bioactive molecules and have recently gained attention in the pharmaceutical sector due to their ability to transport hydrophilic and hydrophobic drugs. Recent studies have recognized the biological activity of the oil of Bixa orellana L. (AO) with regards to its healing, antioxidant, antibacterial, and anti-leishmanial properties. Therefore, the purpose of this study is the preparation and characterization of hybrid systems based on lipid nanocarriers and laponite for the delivery of AO. NLCs were prepared by the fusion-emulsification method, using cetyl palmitate (CP) or myristyl myristate (MM), AO, and Poloxamer 188. The morphology, hydrodynamic diameters, zeta potential (ZP), polydispersity index (PDI), thermal analysis, X-ray diffraction analysis (XRD), viscosity behavior, and cytotoxicity testing of the hybrid systems were performed. The thermal study and X-ray diffraction analyses (XRD) revealed polymorphic structural changes compatible with the amorphization of the material. Rheological assays highlighted a typical pseudoplastic behavior in all systems (MM and CP with LAP). The hybrid systems’ morphology, size diameters, and PDIs were similar, preset spherical and monodisperse structures (≈200 nm; <0.3), without significant change up to sixty days. The ZP values differed from each other, becoming higher with increasing AO concentration. XEDS spectra and elemental X-ray maps show peaks of lipids (organic components, C and O) and inorganic components O, Mg, and Si. All samples showed cell viability above 60%. The results indicated a stable, biocompatible hybrid system that can be an alternative for topical application.

show abstract

“…Furthermore, the stratum corneum -the most superficial layer of the epidermis -is the initial obstacle to skin permeation by exogenous factors, including topical drugs (Lane, 2013;Santos & Costa, 2015;Souto et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Polymeric pullulan films incorporated with extract of Cyclospermum leptophyllum (pers.) Sprague for healing purposes

Andrighetti

Jacques²,

Schmitt³

et al. 2022

RSD

View full text Add to dashboard Cite

Healing films provide excellent results in the adjuvant treatment of injuries. Its association with plant extracts allows the achievement of therapeutic activities, favoring skin regeneration. This study aimed to develop pullulan films incorporated with an extract from the aerial parts of Cyclospermum leptophyllum to be used as healing dressings and to evaluate their morphological and physicochemical characteristics and their potential antioxidant activity. Polymeric films in the proportion of 4% PU (m/v) and 15% plant extract and control films composed only of the polymer matrix were produced using the casting method. The films were evaluated for thickness, visual aspects, solubility, water vapor permeability, swelling, degradation, and antioxidant activity. They showed good appearance and flexibility but heterogeneity due to the precipitation of components. A high degree of solubility and swelling was observed, and despite its rapid dissolution in contact with water, the formation of a hydrogel can enable greater adherence to wounds. The films have controlled water vapor transmission, that allows gas exchange. A DPPH radical inhibition rate of 17.23% was obtained, proving its antioxidant activity. Therefore, the biofilms produced have healing potential, which can be better studied in the future through tests demonstrating antimicrobial, and anti-inflammatory activities.

show abstract

Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair

Cited by 17 publications

References 100 publications

The Use of Proteins, Lipids, and Carbohydrates in the Management of Wounds

The Use of Proteins, Lipids, and Carbohydrates in the Management of Wounds

Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations

Polymeric pullulan films incorporated with extract of Cyclospermum leptophyllum (pers.) Sprague for healing purposes

Contact Info

Product

Resources

About