Lipid Profile of Patients with Liver Cirrhosis in Jos, Nigeria

Okeke, EN; Daniyam, CA; Akanbi, Maxwell O; Ugoya, SO; Agaba, Emmanuel I

doi:10.4314/jmt.v12i2.69317

Cited by 3 publications

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“…This finding is similar to the results of a study done in India 34. However, in contrast to this, some other studies revealed that serum triglyceride levels decreased in cirrhosis 332…”

Section: Discussionmentioning

confidence: 80%

“…Few studies on cirrhosis of liver showed that serum HDL cholesterol, LDL cholesterol and total cholesterol values were significantly diminished 331. In a Nigerian study, the median total cholesterol and HDL cholesterol levels were significantly higher in controls compared with cirrhotic patients; however, LDL cholesterol levels were higher in controls compared with cirrhotic patients and the difference was not statistically significant 32. The serum LDL cholesterol level is inversely proportional to the severity of liver damage and therefore, it is expected that the serum LDL cholesterol would be low in cirrhotic patients 31.…”

Section: Discussionmentioning

confidence: 92%

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Serum lipid profile in alcoholic cirrhosis: A study in a teaching hospital of north-eastern India

2013

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Background:Alcoholic cirrhosis is often associated with impaired lipid metabolism. However, there are only a few studies regarding lipid profile in alcoholic cirrhosis that have been undertaken in India. The aim of the study is to assess the degree of alteration of serum lipid profile in alcoholic cirrhotic patients and also to detect its relationship with the age of the patients and the alcohol consumption pattern.Patients and Methods:This cross-sectional study was conducted in a teaching hospital of north-eastern India for 1 year with 100 patients with alcoholic cirrhosis (cases) and 50 healthy individuals (controls) without history of alcohol consumption. A questionnaire of personal characteristics including history of alcoholism was completed for each patient. Serum lipid profile (total, low-density lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol and triglyceride) was recorded for each case and control. t test of significance was applied for statistical analysis.Results:Majority of the cases were in the 41-50 years age group. There was no relationship of cirrhosis with the type of alcoholic beverage, but a definite relationship was observed with the quantity and the duration of alcohol consumption. In patients with cirrhosis, the total serum cholesterol level was decreased. There was a significant decrease in serum HDL and LDL cholesterol compared with the control group ( P < 0.001). However, the serum triglyceride levels were significantly increased in alcoholic cirrhotic patients compared with the control group ( P < 0.001).Conclusion:In this study, we found that there was marked alteration of serum lipid profile values in patients with alcoholic cirrhosis compared with normal, non-cirrhotic individuals. Therefore, a search for lipid profile abnormality should be performed in every cirrhotic patient.

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“…This finding is similar to the results of a study done in India 34. However, in contrast to this, some other studies revealed that serum triglyceride levels decreased in cirrhosis 332…”

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 92%

Serum lipid profile in alcoholic cirrhosis: A study in a teaching hospital of north-eastern India

2013

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“…4 Some studies have reported that TC and HDL levels were significantly raised in non-cirrhotic patients compared with cirrhotic patients and in same study, LDL was higher in non-cirrhotic compared with cirrhotic patients and difference was not statistically significance. 20 However, an author study reported that there may be increase TC and LDL in alcoholic cirrhotic patients. 21 Hence, it can be said that in alcoholic cirrhosis patients, dyslipidemia may be seen.…”

Section: Discussionmentioning

confidence: 99%

The study of serum lipid profile in patients with cirrhosis of liver

2023

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Background: Cirrhosis of liver is a chronic condition of hepatocellular failure due to different etiology which leads multiple complications and increases the morbidity and mortality. The aim of the study was to study the lipid profile in patients with cirrhosis and to assess if it relates to the severity of the cirrhosis. Hence, abnormal lipid profile may be the surrogate marker of the severity of cirrhosis of liver. Aims and Objectives: Study lipid profiles in cirrhotic patients and compare with healthy population and to relate severity of cirrhosis of liver with the finding of abnormal lipids. Materials and Methods: This study was a cross-sectional study conducted in the department of internal medicine over a period of 6 months. It was carried on 51 cirrhotic patients and 50 non-cirrhotic subjects who attended the outpatient and inpatient department. The cirrhosis of liver was established with history, examination, and investigations. Results: The mean total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very LDL (VLDL), respectively, of non-cirrhotic subjects was found to be higher than cirrhotic patients, respectively. All lipid profiles TC, TG, HDL, LDL, and VLDL value found to be (P<0.05) which were statically significant. Serum TC, TG, HDL, LD, and VLDL level decreased more in Child-Turcotte-Pough Criteria (CTP) Class C as compared to CTP Class B. The TC, HDL, and LDL belonged cases to the CTP class C and B showed (P<0.05) found statistical significance, which can be further correlated with the severity of cirrhosis. In the present study, the level of TG and VLDL was (P>0.05) found statistically non-significant. Conclusion: All the lipid parameters decrease in cirrhotic patients as compare to non-cirrhotic subjects and progressively lower the parameters as severity of liver disease increased.

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Effects of red and pale green variety of Catha edulis on liver and kidney of human consumers in Meru county, Kenya

Mworia¹,

Kinge²,

Kahato³

et al. 2017

Int. J. Adv. Multidiscip. Res.

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Catha edulis (miraa) is a large green shrub that grows at high altitudes. It is a well-known tree in Kenya.The leaves of the C.edulis plant contain alkaloids structurally related to amphetamine and they are currently chewed daily by a high proportion of the adult population in Kenya for the resulting pleasant mild stimulant action.The habit of C.edulis chewing is widespread in Kenya especially in C.edulis producing areas and this poses a public health problem.This study was conducted tocompare the effects of red and pale green variety of Catha edulis on human consumers in Meru County. Blood was collected from 198 Catha edulis chewers and 193 non-chewers.Liver biochemical parameters were affected by the red variety Catha edulis chewing which was shown by increased activity of alanine aminotransferase (ALA), total bilirubin (TB) and alkaline phosphatase (ALP) as compared to the pale green variety. Renal biochemical parameters were not affected. In conclusion, red variety Catha edulis is more potent than the pale green variety hence responsible for hepatic toxicity but not renal toxicity.

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Lipid Profile of Patients with Liver Cirrhosis in Jos, Nigeria

Cited by 3 publications

References 0 publications

Serum lipid profile in alcoholic cirrhosis: A study in a teaching hospital of north-eastern India

Serum lipid profile in alcoholic cirrhosis: A study in a teaching hospital of north-eastern India

The study of serum lipid profile in patients with cirrhosis of liver

Effects of red and pale green variety of Catha edulis on liver and kidney of human consumers in Meru county, Kenya

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