Lipid profile parameters in normal and preeclampsia complicating pregnancies - A prospective observational study

Isukapalli, Vani

doi:10.17812/ajsmr2015114

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…The present study also showed a significant rise in TG in pre-eclamptic patients in comparison to normotensive pregnant women. The other studies that support our study are Vani et al [19], Somani et al [20], and Gohil et al [21].…”

Section: Discussionsupporting

confidence: 88%

Study of Thyroid Profile, Uric Acid, Creatinine and Lipid Profile in Pre-Eclampsia Patient

Dehariya¹,

Jaiswal²,

UPADHYAY³

et al. 2023

Asian J Pharm Clin Res

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Objectives: (1) To evaluate and compare the thyroid profile and lipid profile in preeclampsia in a normotensive pregnant female in the third trimester of pregnancy. (2) To estimate and compare serum uric acid and serum creatinine in preeclampsia in normotensive pregnant females. Methods: In the present study, 154 patients, of which 79 preeclampsia (cases) and 75 (controls), were selected randomly and matched with their gestational age in patients who attended an ANC clinic at the Department of Obstetrics and Gynecology, NSCB Medical College, Jabalpur, from March 2016 to August 2017. All patients were evaluated for their lipid profile, thyroid profile, serum uric acid, and serum creatinine. The study includes patient’s specific detailed clinical history, physical examination findings, and a report of relevant investigations recorded from the patient who presented with pre-eclampsia and normotensive pregnant female attending the ANC Clinic of N.S.C.B. Medical College, Jabalpur. Results: The most common age group for preeclampsia was 20–24 years. Preeclampsia was most common in the nullipara as compared to the multipara. Pre-eclampsia cases commonly occur in low-socioeconomic and rural areas. In this study, pre-eclamptic women showed higher serum concentrations of total cholesterol (221.60±22.55), low density lipoprotein (LDL) (134.44±16.96), Very LDL (48.48±6.88) and Triglyceride (243.50±32.33) when compared to normotensive women, which was statistically significant. In this study, a statistically significant decrease in HDLC (34.55±5.37) was observed in pre-eclamptic women. An increase in serum creatinine was observed in women with pre-eclampsia. The mean serum creatinine level was (1.21±0.47). Conclusion: Our study concludes that nulliparous and low-socio-economic women had a higher risk of pre-eclampsia. Maternal age between 20 and 24 years are more prone to develop pre-eclampsia. Serum uric acid levels are significantly higher in pre-eclampsia patients and could be a useful indicator of maternal and fetal complications in hypertensive patients.

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Section: Discussionsupporting

confidence: 88%

Study of Thyroid Profile, Uric Acid, Creatinine and Lipid Profile in Pre-Eclampsia Patient

Dehariya¹,

Jaiswal²,

UPADHYAY³

et al. 2023

Asian J Pharm Clin Res

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“…In the current study, VLDL measurements were significantly [P < 0.088] high in the preeclamptic group which may be as a result of high TGs levels causing high entrance of VLDL that carries the endogenous TGs into the circulation. Similar results were seen in the research done via Vani et al [23] In contradiction to results of the present work, Ghodke et al [24] are not capable to expect the incidence of PET, diabetes, and PRL by measuring VLDL-C levels of the mid trimester as the level are within normal concentration.…”

Section: Disucssionsupporting

confidence: 64%

Maternal plasma lipid concentration in third trimester of women with preeclampsia and normotensive pregnancy

Mohammed¹,

Ayad

El-Gazzar

et al. 2020

International Journal of Medical Arts

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Background: Preeclampsia is one of complications of pregnancy. It is responsible for morbidity for mother and fetus. Preeclampsia is a pregnancy multisystem disorder. Abnormal lipid profile has an effect on endothelial dysfunction. The association of serum lipid profile with preeclampsia is suggested to reflect new diagnostic tools. Pregnancy dyslipidemia is associated with an increased risk of preeclampsia. Compared to healthy pregnancy, women with preeclampsia have an abnormal lipid profile. Aim of the work: The aim of this work is comparison between normotensive women and preeclamptic women by serum lipid profile at third trimester. Patients and Methods: The present study conducted on 70 pregnant women in the Department of Obstetrics and Gynecology, at Al-Azhar University hospital [Damietta], which was conducted during 2019 [from April to December]. A study comprised 35 normotensive pregnant women as controls and 35 preeclampsia cases. The blood samples were analyzed for serum triglycerides [TGs], total cholesterol [TC], high-density lipoprotein-cholesterol [HDL-C], lowdensity Lipoprotein-Cholesterol [LDL-C], very low-density Lipoprotein-Cholesterol [VLDL-C], Apo lipoprotein-A1 [Apo-A1] and Apo lipoprotein-B[Apo-B]. Results: There was significant difference between group A and B as regard Apo B/ Apo A1, cholesterol, TGS, LDL and VLDL. They are higher in group B. Conclusion: In the third trimester of pregnancy, preeclamptic women have altered levels of serum lipid profile. The most significant test is Apo B/A1 ratio with accuracy [72.7%].

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“…Vani I et al 16 conducted an open labeled clinical study to compare the lipid profile in normotensive and hypertensive pregnant women. The study included two groups-50 normotensive and 50 preeclamptic pregnant women in whom fasting blood samples were sent for estimation of serum lipid profile during their third trimester.…”

Section: Discussionmentioning

confidence: 99%

Study of serum lipid profile in pregnancy and its correlation with preeclampsia

Kaur¹,

Nidhi²,

Fayyaz³

2019

OGIJ

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Objective: To study serum lipid profile between 13-20 week of pregnancy & to look for correlation, if any, of serum lipid levels in pregnancy with preeclampsia and to find out correlation, if any, between serum lipids profile and fetomaternal outcome. Material and methods: We carried out a Longitudinal, Descriptive type of observational study in the department of Obstetrics and Gynecology at SDMH, Jaipur from June 2016 to April 2017.Total 125 patients were enrolled in study fulfilling inclusion and exclusion criteria between 13-20 weeks of gestation at SDMH, Jaipur, 14 patients were lost during follow up finally 111 patients remained for analysis .Serum lipid profile was done in all patients and these were followed till delivery for presence and absence of preeclampsia. Results: The mean level of TC in participants developed preeclampsia was 224.36±43.68mg/dl. This was significantly higher as compared to normotensive group 180.77±36.58mg/dl. Conclusion: Early prediction of preeclampsia can be used as a tool for primary prevention before the development of the disease. There is no single specific test available to predict the preeclampsia till date. So there is need of further research to discover the specific test to predict preeclampsia

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Lipid profile parameters in normal and preeclampsia complicating pregnancies - A prospective observational study

Cited by 4 publications

References 5 publications

Study of Thyroid Profile, Uric Acid, Creatinine and Lipid Profile in Pre-Eclampsia Patient

Study of Thyroid Profile, Uric Acid, Creatinine and Lipid Profile in Pre-Eclampsia Patient

Maternal plasma lipid concentration in third trimester of women with preeclampsia and normotensive pregnancy

Study of serum lipid profile in pregnancy and its correlation with preeclampsia

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