Lipid Profile Status of Chronic Obstructive Pulmonary Disease in Hospitalized Patients

Abstract

ORIGINAL ARTICLEare characterized by an increase in cough, sputum production, worsening dyspnoea, or sputum purulence 4 . Although respiratory infections are suspected to be the main factor for the exacerbations, other factors such as industrial pollutants, allergens, sedatives, congestive heart failure, and pulmonary embolism, have also been identified 4,5,6,7 . Despite the frequency and the consequences of the exacerbation of COPD (ECOPD), its underlying pathological mechanism remains poorly understood. Only a handful of studies have focused on the functional 8 ,

Association between the Serum Metabolic Profile and Lung Function in Chronic Obstructive Pulmonary Disease

“…In our study, the COPD patients, mainly females, had relatively fewer animal fats in their diet, which might be associated with a reduced production of non-oxidized lipid byproducts. However, our finding of higher median circulatory LDL level in the COPD patients (although not statistically significant) is similar to previous studies [4,5,14,15] and could be the result of an accelerated production of oxidized fat due to exposure to tobacco or biomass smoke [16].…”

“…It is reported that COPD patients are likely to remain at a high risk of developing metabolic syndrome due to high levels of nonesterified fatty acid released into circulation, and as the skeletal muscles are prone to have affinity toward triglycerides and free fatty acid, patients with dyslipidemia or uncontrolled circulating lipid level may be at potential risk [17]. Our findings of an inverse relationship between triglyceride and BMI and FRC indicate a negative influence of lipid metabolites on the biophysical properties of the lungs by reducing the expiratory reserve volume (since the RV does not change much in obesity) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Cirillo et al [21], in an analysis of 18,162 participants from the third National Health and Nutritional Examination Survey, found that total cholesterol and LDL had no significant influence on the decline of FEV 1 , which was also observed in our study.…”

“…We measured airway resistance at the frequency between 5Hz and 20 Hz, and three successive efforts were recorded. We considered resistance at 5Hz (R 5 ), resistance at 20 Hz (R 20 ), frequency dependence (R [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] ), reactance at 5 Hz (X 5 ), area under reactance (AX), and resonance frequency (Fres) as the principal outcome variables.…”

“…However, a logical percept of the link between high circulatory free fatty acid and COPD could be due to an underlying effect of reduced oxidation of fat leading to metabolic syndrome. In two case-control studies, circulating low-density lipoprotein levels have been found high in patients with bronchial asthma and COPD, compared to healthy individuals [4,5]. However, the relationship between lipid profile and lung function in COPD remains unclear.…”

A study to assess nutritional profile in chronic obstructive pulmonary disease patients

“…The results of our study doesn't correlate with study conducted by K Begum et al in 2010 which showed that TC concentration is statically significant in case group as compared with control group. 19 HDL showed no significant difference between the cases and control groups. These findings are in accordance with study conducted by Attaran D et al in 2013 which showed that HDL concentration in COPD was significantly higher in cases as compared to control group.…”