Lipid profile studies in long term thiazide treated hypertensives

Rao, Raghavendra; Bm, Hegde; Bhat, E. Keshav; Vidyavathi, U.; Rao, Raghavendra

doi:10.1136/pgmj.67.789.652

Cited by 2 publications

(1 citation statement)

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“…The duration of treatment, in this study, was more than one year which may explain the minimal alteration in lipid profile caused by the treatment. These results are consistent with other workers (21,22) .…”

Section: Discussionsupporting

confidence: 94%

Effect of hydrochlorothiazide with amiloride on serum lipidprofile and malondialdehyde in hypertensive women

Ahmed¹

2010

Ann Coll Med Mosul

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Objectives:To study the effect of hydrochlorothiazde with amiloride on serum lipid profile and malondialdehyde (MDA) in hypertensive women. Methods: A case-control study was carried out in the Outpatient Department in Ibn-Sina General Hospital, Mosul, during the period from November 2005 to May 2006. Thirty hypertensive women treated with 50 mg hydrochlorothiazide and 5 mg amiloride per day in a single dose. The duration of treatment was between 1-5 years. Thirty mild hypertensive women (newly diagnosed, before treatment) were also included as a control group. Blood samples were taken from both the treated patients and controls and analysed for serum lipid profile and MDA. Non-paired 't-test was used to compare between parameters. Results: Hydrochlorothiazide with amiloride did not change serum lipid profile significantly in the hypertensive women compared with the control group, although serum lipid profile was in the upper normal value. The combination therapy decreased serum MDA significantly (P<0.05). Conclusion: Chronic use of combination therapy of hydrochlorothiazide with amiloride had no significant effect on serum lipid profile, but this combination reduced lipid peroxidation in hypertensive women. Lipid peroxidation is a consequence and not a cause of hypertension.

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Section: Discussionsupporting

confidence: 94%