Lipid Rafts from Olfactory Ensheathing Cells: Molecular Composition and Possible Roles

Campos, Fernanda S.O.; Piña-Rodrigues, Felipe Márquez; Reis, Alice H.; Atella, Geórgia C.; Mermelstein, Cláudia; Allodi, Silvana; Cavalcante, Leny A.

doi:10.1007/s10571-020-00869-4

Cited by 11 publications

(11 citation statements)

References 66 publications

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“…Ganglioside GT3 is a kind of ganglioside mainly composed of glycosphingolipids and sialic acids linking to sugar chain (Labrada et al, 2018). It is a type of component concentrating on the lipid raft in the plasma membrane (Campos et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Multi-Omics Prognostic Signatures Based on Lipid Metabolism for Colorectal Cancer

Sun

Liu

Chen

et al. 2022

Front. Cell Dev. Biol.

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Background: The potential biological processes and laws of the biological components in malignant tumors can be understood more systematically and comprehensively through multi-omics analysis. This study elaborately explored the role of lipid metabolism in the prognosis of colorectal cancer (CRC) from the metabonomics and transcriptomics.Methods: We performed K-means unsupervised clustering algorithm and t test to identify the differential lipid metabolites determined by liquid chromatography tandem mass spectrometry (LC-MS/MS) in the serum of 236 CRC patients of the First Hospital of Jilin University (JLUFH). Cox regression analysis was used to identify prognosis-associated lipid metabolites and to construct multi-lipid-metabolite prognostic signature. The composite nomogram composed of independent prognostic factors was utilized to individually predict the outcome of CRC patients. Glycerophospholipid metabolism was the most significant enrichment pathway for lipid metabolites in CRC, whose related hub genes (GMRHGs) were distinguished by gene set variation analysis (GSVA) and weighted gene co-expression network analysis (WGCNA). Cox regression and least absolute shrinkage and selection operator (LASSO) regression analysis were utilized to develop the prognostic signature.Results: Six-lipid-metabolite and five-GMRHG prognostic signatures were developed, indicating favorable survival stratification effects on CRC patients. Using the independent prognostic factors as variables, we established a composite nomogram to individually evaluate the prognosis of CRC patients. The AUCs of one-, three-, and five-year ROC curves were 0.815, 0.815, and 0.805, respectively, showing auspicious prognostic accuracy. Furthermore, we explored the potential relationship between tumor microenvironment (TME) and immune infiltration. Moreover, the mutational frequency of TP53 in the high-risk group was significantly higher than that in the low-risk group (p < 0.001), while in the coordinate mutational status of TP53, the overall survival of CRC patients in the high-risk group was significantly lower than that in low-risk group with statistical differences.Conclusion: We identified the significance of lipid metabolism for the prognosis of CRC from the aspects of metabonomics and transcriptomics, which can provide a novel perspective for promoting individualized treatment and revealing the potential molecular biological characteristics of CRC. The composite nomogram including a six-lipid-metabolite prognostic signature is a promising predictor of the prognosis of CRC patients.

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Section: Discussionmentioning

confidence: 99%

Multi-Omics Prognostic Signatures Based on Lipid Metabolism for Colorectal Cancer

Sun

Liu

Chen

et al. 2022

Front. Cell Dev. Biol.

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“…Flotillins are peripherally membrane-associated proteins, which can interact with F-actin and thus link rafts to cytoskeleton ( Langhorst et al., 2007 ). A study revealed that Cav-1 colocalizes with flotillin and α-actinin, another F-actin-crosslinking protein, both of which are enriched in lipid rafts and play an important role in cell migration and axon ensheathment ( Campos et al., 2021 ). Interactions between Cav-1 and actin-associated proteins and their effects on cell migration are also summarized in Figure 1 .…”

Section: Interactions Between Cav-1 and Actin Cytoskeleton In Terms O...mentioning

confidence: 99%

Interactive mechanisms between caveolin-1 and actin filaments or vimentin intermediate filaments instruct cell mechanosensing and migration

Tang

Zhang

Mei

et al. 2022

Journal of Molecular Cell Biology

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Section: Transplant Cells From Neural Originmentioning

confidence: 99%

“…OECs ( Figure 1 ) are a distinct category of the glia situated in the olfactory system [ 89 , 90 ]. In the olfactory system, the renewal of sensory neurons occurs constantly throughout life [ 89 , 90 ]. OECs are capable of migrating within the central nervous system (CNS) and coexist in an astrocyte-rich locations [ 90 , 91 ].…”

Section: Transplant Cells From Neural Originmentioning

confidence: 99%

Elucidating the Pivotal Neuroimmunomodulation of Stem Cells in Spinal Cord Injury Repair

Richard¹,

Sackey

2021

Stem Cells International

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Spinal cord injury (SCI) is a distressing incident with abrupt onset of the motor as well as sensory dysfunction, and most often, the injury occurs as result of high-energy or velocity accidents as well as contact sports and falls in the elderly. The key challenges associated with nerve repair are the lack of self-repair as well as neurotrophic factors and primary and secondary neuronal apoptosis, as well as factors that prevent the regeneration of axons locally. Neurons that survive the initial traumatic damage may be lost due to pathogenic activities like neuroinflammation and apoptosis. Implanted stem cells are capable of differentiating into neural cells that replace injured cells as well as offer local neurotrophic factors that aid neuroprotection, immunomodulation, axonal sprouting, axonal regeneration, and remyelination. At the microenvironment of SCI, stem cells are capable of producing growth factors like brain-derived neurotrophic factor and nerve growth factor which triggers neuronal survival as well as axonal regrowth. Although stem cells have proven to be of therapeutic value in SCI, the major disadvantage of some of the cell types is the risk for tumorigenicity due to the contamination of undifferentiated cells prior to transplantation. Local administration of stem cells via either direct cellular injection into the spinal cord parenchyma or intrathecal administration into the subarachnoid space is currently the best transplantation modality for stem cells during SCI.

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Lipid Rafts from Olfactory Ensheathing Cells: Molecular Composition and Possible Roles

Cited by 11 publications

References 66 publications

Multi-Omics Prognostic Signatures Based on Lipid Metabolism for Colorectal Cancer

Multi-Omics Prognostic Signatures Based on Lipid Metabolism for Colorectal Cancer

Interactive mechanisms between caveolin-1 and actin filaments or vimentin intermediate filaments instruct cell mechanosensing and migration

Elucidating the Pivotal Neuroimmunomodulation of Stem Cells in Spinal Cord Injury Repair

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