Lipid rafts in cytokine signaling

P-glycoprotein and ‘lipid rafts’: some ambiguous mutual relationships (floating on them, building them or meeting them by chance?)

“…However, the role and even the participation of membrane microdomains in these phenomena of cytokine secretion and signalling are still poorly described, even if they are often suspected [169], making difficult to rely a defined involvement of P-gp with rafts in this context. However, a general role for rafts in constitutive and regulated secretion processes has been proposed [170].…”

Shedding and uptake of gangliosides and glycosylphosphatidylinositol-anchored proteins

“…At the cell membrane gangliosides and GPI-anchored proteins form membrane microdomains called lipid rafts that are involved in the regulation and modulation of numerous cellular processes. Many reviews have been recently published on GPI-anchored proteins [1][2][3][4], gangliosides [5][6][7][8][9] and lipid rafts [10][11][12][13][14] and they should be consulted for more detailed consideration of these molecules and their functions. In this review we would like to look at them through a different perspective, not addressing the role of gangliosides and GPI-linked proteins in specific cellular processes, but focusing on their one peculiar characteristic: the ability to be released from the membrane of one cell and incorporated into the membrane of another cell.…”

“…Lipid rafts have been extensively reviewed in the last few years [10][11][12][13][44][45][46][47][48], and only some of their aspects will be presented here.…”

Anti–β2-microglobulin monoclonal antibodies induce apoptosis in myeloma cells by recruiting MHC class I to and excluding growth and survival cytokine receptors from lipid rafts

“…15,16 IL-6 binds to IL-6R, recruits the receptors to lipid rafts, and stimulates downstream antiapoptotic signaling pathways to resist dexamethasone treatment. In this study, we confirmed that stimulation of myeloma cells by IL-6 or IGF-I led to relocation of gp130 or IGF-IR␤, and its substrate IRS-1, to lipid rafts and increased affinity of receptor binding to caveolin-1, which regulates the structure and function of lipid rafts.…”

“…15 These raft domains act as platforms for conducting different signals into cells for various functions, including cytokine-mediated growth signaling. 16 Integral proteins in the cellular membrane, such as caveolins and flotillins, can modify lipid rafts structurally and functionally, and may therefore affect subsequent cellular functions. 17,18 Some reports have shown that growth factors, such as IL-6, induce translocation of their receptors to lipid rafts and confer protection against dexamethasone treatment.…”