Lipid Spectrum in Patients with Atherosclerosis of Various Localizations

We studied the balance of fatty acids and their correlation with parameters of lipid metabolism and inflammation markers in men with coronary atherosclerosis. In the blood of patients and healthy men, the content of myristic (C14:0), pentadecanoic (C15:0), palmitic (C16:0), stearic (C18:0), arachidic (C20:0) and docosanic (C22:0), TNFα, IL-1β, IL-6, IL-8, C-reactive protein, cholesterol, triglycerides, HDL, and LPO intensity were measured. In patients with coronary atherosclerosis, increased concentrations of saturated fatty acids, triglycerides, LPO products, IL-6, IL-8, and C-reactive protein were found. Correlation analysis revealed multiple correlations between the studied fatty acids, correlation of C16:0, C18:0, and C20:0 with inflammation markers, C14:0, C16:0, and C18:0 with triglyceride level, C16:0, C18:0, and C20:0 with cholesterol. The contents of C14:0, C15:0, C16:0, and C18:0 correlated with the presence of coronary atherosclerosis. Lipid metabolism disturbances in coronary atherosclerosis were accompanied by changes in not only lipid spectrum and inflammation markers, but also fatty acids balance.

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Balance of Fatty Acids and Their Correlations with Parameters of Lipid Metabolism and Markers of Inflammation in Men with Coronary Atherosclerosis

Polonskaya

Шрамко

Морозов

et al. 2017

Bull Exp Biol Med

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Assessment of risk factors for multifocal atherosclerosis in the workers of the main professions of coal enterprises in the South of Kuzbass

Filimonov¹,

Кorotenko²,

Rumpel³

et al. 2020

Myditsina truda I promyshlennaya ekologiy

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Introduction. The problem of high mortality from cardiovascular diseases is caused, among other things, by asymptomatic atherosclerosis, which proceeds latently for a long time and manifests itself as a serious vascular catastrophe, which is of particular importance for people working at production facilities with difficult and dangerous working conditions.The aim of the study was to assess the risk factors for atherosclerosis and the state of the vascular wall in the workers of the main professions of coal enterprises in the South of Kuzbass.Material and methods. In total, the study included 384 people (men), of whom 266 were the workers in coal mines in the South of Kuzbass and 118 people who were not employed in the coal industry, aged 40 to 55 years. The diagnosis of atherosclerosis was carried out on the ultrasound system “Vivid E9” of the manufacturing company GE using a linear sensor for measuring the thickness of the intima-media complex and visualization of atherosclerotic plaques. To identify significant risk factors, anthropometric, anamnestic data, indices of lipid and carbohydrate metabolism, and the presence of arterial hypertension were studied.Results. Significant differences in the frequency of asymptomatic atherosclerosis in the form of an increase in intima-media thickness by more than 1 mm and / or the presence of atherosclerotic plaques in both groups were not found: 60.2% among the miners and 62.3% among non-coal mining workers (p=0.703); at the same time, the percentage of detection of atherosclerotic plaques in arteries was significantly lower among coal workers — 46.9% versus 60.5% among people in the comparison group (p=0.016). The common risk factors for all examined subjects were arterial hypertension and increased level of glycated hemoglobin; in turn, in coal miners additional risk factors were increased values of low density lipoproteins and waist-hip index, as well as burdened heredity for cardiovascular diseases, and among the individuals not employed in the coal industry it was smoking.Conclusions. The most significant risk factors for atherosclerosis in coal industry workers were arterial hypertension, raised values of glycated hemoglobin, low density lipoproteins and waist-hip index, as well as burdened heredity for cardiovascular diseases. Significant differences in the frequency of asymptomatic atherosclerosis in the form of an increase in the thickness of the intima-media complex of the main arteries and the presence of atherosclerotic plaques in both groups were not established, but the percentage of the detection of atherosclerotic plaques was lower among coal miners.The authors declare no conflict of interests.

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Clinical and experimental studies of cardiovascular disorders in the conditions of fluoride intoxication of the body

Ядыкина¹,

Коротенко²,

Panev³

et al. 2020

Myditsina truda I promyshlennaya ekologiy

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Introduction. Th e aluminum industry occupies one of the leading positions among other branches of non-ferrous metallurgy in terms of the prevalence of occupational pathology, many questions of pathophysiological mechanisms of its development remain open. Among the concomitant somatic diseases in workers engaged in the production of aluminum, the fi rst place is occupied by the pathology of the cardiovascular system against the background of chronic fl uoride intoxication of the body.The aim of the study is to identify some features of the formation of cardiovascular pathology in the conditions of prolonged exposure to high doses of fl uorides on the body. Materials and methods. A complex analysis of the prevalence of cardiovascular pathology and specifi c features of the pathogenesis of arterial hypertension, coronary heart disease and atherosclerosis was performed based on clinical and genetic research methods in 246 workers with fl uorosis and in the comparison group (106 people). Experimental studies of the morphofunctional state of the myocardium and blood vessels in conditions of chronic fl uoride exposure with histological analysis of tissues were performed on white laboratory rats.Results. In the clinical pilot study with the assessment of pathological disorders of the cardiovascular system in terms of fl uoride intoxication revealed the structure and frequency of cardiovascular disease metallurgists main and auxiliary workers, employed in the production of aluminium. Th e Association of VEGF, IL1β, GSTT 1, GSTM1, СYP1А1, CYP1A2 genes with concomitant coronary, obliterating and multifocal atherosclerosis, heart rhythm disorders, arterial hypertension, coronary heart disease complicated by pyelonephritis and liver steatosis was determined. Th e experiment shows the toxic eff ect of fl uoride on the myocardium and coronary vessels.Conclusions. In the ranking structure of professionally determined morbidity in workers engaged in the production of aluminum, cardiovascular pathology prevails, in particular, arterial hypertension, coronary heart disease, atherosclerosis against the background of pronounced multi-organ manifestations, violations of bone metabolism, confi rmed by experimental data.

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Lipid Spectrum in Patients with Atherosclerosis of Various Localizations

Cited by 3 publications

References 9 publications

Balance of Fatty Acids and Their Correlations with Parameters of Lipid Metabolism and Markers of Inflammation in Men with Coronary Atherosclerosis

Balance of Fatty Acids and Their Correlations with Parameters of Lipid Metabolism and Markers of Inflammation in Men with Coronary Atherosclerosis

Assessment of risk factors for multifocal atherosclerosis in the workers of the main professions of coal enterprises in the South of Kuzbass

Clinical and experimental studies of cardiovascular disorders in the conditions of fluoride intoxication of the body

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