Lipid status, paraoxonase-1 activity and metabolic parameters in serum of heifers and lactating cows related to oxidative stress

Antončić-Svetina, Maja; Turk, Romana; Svetina, Ante; Gereš, Darko; Rekić, Branka; Juretić, Dubravka

doi:10.1016/j.rvsc.2010.05.022

Cited by 15 publications

(18 citation statements)

References 27 publications

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“…Reduced triglyceride with higher cholesterol concentrations in serum were found in Holstein-Friesian cows on about the 50th day of lactation (Kulka et al 2014). Also, higher concentrations of cholesterol and HDL-C were found in lactating cows than in heifers (Antončić--Svetina et al 2011).…”

Section: Discussionmentioning

confidence: 89%

Serum paraoxonase 1 (PON1) activity and lipid metabolism parameters changes in different production cycle periods of Holstein-Friesian, Polish Red and Norwegian breeds

Kulka¹,

Kołodziejska-Lesisz²,

Kluciński³

2016

Polish Journal of Veterinary Sciences

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We investigated the measurement of paraoxonase 1 (PON1), as a potential marker of redox state changes in dairy cows, its involvement in lipid metabolism and compared it with superoxide dismutase (SOD) activity changes. We also evaluated lipid metabolism parameters associated with dairy production. PON1 paraoxonase and arylesterase acitvities, SOD activity, beta-hydroxybutyrate (BHB), uric acid (UA), high density lipoprotein (HDL), low density lipoprotein (LDL), cholesterol and triglyceride concentrations were measured in Holstein-Friesian, Polish Red and Norwegian breeds serum in two production cycles. Our data showed a significant postpartum depletion in PON1 activity and lipoprotein and lipid products concentrations, with elevated BHB values. However, there were no significant changes in SOD activity and uric acid concentrations in Holstein-Friesian and Polish Red breeds after calving. At lactation peak there was a significant SOD activity decrease correlated with standardized PON1 activity depletion in all examined breeds. The results suggest that PON1 might be a better parameter for minimal redox state changes in serum, shortly after labour in the examined breeds.

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Section: Discussionmentioning

confidence: 89%

Serum paraoxonase 1 (PON1) activity and lipid metabolism parameters changes in different production cycle periods of Holstein-Friesian, Polish Red and Norwegian breeds

Kulka¹,

Kołodziejska-Lesisz²,

Kluciński³

2016

Polish Journal of Veterinary Sciences

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“…The latter has only been determined in cows during pregnancy, lactation, milk production or the administration of certain substances (Castillo et al, 2005;Abd Ellah et al, 2009;Pedernera et al, 2009;Albera and Kankofer, 2010;Antoncic-Svetina et al, 2010). However, none of these studies in cows associate exercise with oxidative stress.…”

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confidence: 99%

Effects of an aerobic training program on oxidative stress biomarkers in bulls

Escribano¹,

Túnez²,

Requena³

et al. 2010

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to evaluate the effect of aerobic training (16 weeks -T1 and 24 weeks -T2) on oxidative stress biomarkers. To this end, GSH, GSH-peroxidase (GSH-Px) and catalase (CAT) activity were analysed in plasma. Nine bulls (3-4 years), were included in this work. The exercise training protocol was performed in a track ("taurodromo") three days per week for 24 weeks and consisted of 400 m warming up, 1200 m to 4-5 m/s, two minutes' resting, 1200 m to 4-5 m/s and, finally, 400 m walking. The results reflected that GSH-Px activity was higher at T1 (6.18 ± 0.45) than at baseline (T0; 2.31 ± 0.08) while the GSH level (2.98 ± 0.37) was lower vs. T0 (14.59 ± 3.40). Moreover, there were significant increases in GSH-Px (18.23 ± 1.36) and CAT (2.52 ± 0.04) activities and the recovery of basal values in GSH (11.75 ± 2.84) in T2. In conclusion, the type of training carried out in this study involved two well-defined stages: (i) a period of perturbation, followed by (ii) adaptation. The former stage was characterised by the induction of oxidative stress manifested as a decrease in the GSH, and the latter (T2) by the recovery of this non-enzymatic antioxidant.

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“…PON-1 was down-regulated in group BA (1,46-fold in the proteomic analysis and 1,45-fold in the enzymatic analysis). This enzyme prevents and retards the oxidation of HDL and LDL and therefore inhibits the onset and progression of oxidative stress [17].…”

Section: Discussionmentioning

confidence: 99%

“…This may be due to direct causes (presence of parasites, exposition to microorganisms) or to indirect causes, since diets containing inadequate amounts of nutrients may also indirectly result in oxidative stress by impairing cellular defence mechanisms [21]. A negative energy balance is another major factor in the development of oxidative stress [17]. Other possible origins of oxidative stress are uncomfort and stress.…”

Section: Discussionmentioning

confidence: 99%

Proteomic analysis reveals oxidative stress response as the main adaptative physiological mechanism in cows under different production systems

Marco-Ramell

Arroyo

Saco

et al. 2012

Journal of Proteomics

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Lipid status, paraoxonase-1 activity and metabolic parameters in serum of heifers and lactating cows related to oxidative stress

Cited by 15 publications

References 27 publications

Serum paraoxonase 1 (PON1) activity and lipid metabolism parameters changes in different production cycle periods of Holstein-Friesian, Polish Red and Norwegian breeds

Serum paraoxonase 1 (PON1) activity and lipid metabolism parameters changes in different production cycle periods of Holstein-Friesian, Polish Red and Norwegian breeds

Effects of an aerobic training program on oxidative stress biomarkers in bulls

Proteomic analysis reveals oxidative stress response as the main adaptative physiological mechanism in cows under different production systems

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