Lipid structure and the behavior of cholesteryl esters in monolayer and bulk phases.

Smaby, Janice M.; Baumann, Wolfgang J.; Brockman, Howard L.

doi:10.1016/s0022-2275(20)40032-x

Cited by 31 publications

(35 citation statements)

References 14 publications

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“…The average apparent partial molecular area for cholesteryl oleate of 121 ± 7 A2 is in good agreement, however, with that determined at constant surface pressure by a simple, geometric analysis of its miscibility with a limited number of phospholipids (Smaby et al, 1984). The similarities of co, for cholesteryl oleate, elaidate, linoleate, and linolenate are consistent with similarities in their phase diagrams (Smaby et al, 1979;Smaby & Brockman, 1981b). It is also of interest that co, for cholesteryl arachidonate averages only 92 ± 2 A2 at the monolayer phase boundary because its solubility in the monolayer phase is high relative to cholesteryl oleate Smaby & Brockman, 1981b).…”

Section: Resultssupporting

confidence: 72%

“…For the cholesteryl esters, co/s are considerably larger than partial molecular areas determined previously by extrapolation of average molecular area-composition isobars (Smaby & Brockman, 1981b) or by application of the Crisp model to monolayer phase boundary data (Smaby et al, 1979). As only recently recognized (Smaby et al, 1984), the lower values for the partial molecular areas were obtained because mixing within the monolayer phase was nonideal, and, hence, eq 1 should not have been applied.…”

Section: Resultsmentioning

confidence: 82%

“…As exemplified by Figures 1-4, data for the phase boundary delimiting the monolayer phase can be obtained over a wide range of surface pressures and compositions, and thus, cholesteryl esters provide excellent data for testing this model. As noted previously (Smaby et al, 1979), data plotted according to the Crisp model are often not linear over the entire range of surface pressures and compositions measured. Thus, it does not adequately describe the system nor does it yield any information on the state of the colipid at the phase boundary.…”

Section: Resultsmentioning

confidence: 86%

“…Most of the primary data utilized in this analysis have been published earlier (Smaby et al, 1979(Smaby et al, , 1983(Smaby et al, , 1984 Brockman, 198 la,b; Bhat & Brockman, 1981). Those binary systems which have not are mixtures of cholesteryl oleate or cholesteryl arachidonate with 1-acylglycerophosphocholine (egg), cholesteryl oleate with l-palmitoyl-2-oleoylglycerophosphocholine, and cholesteryl arachidonate with sphingomyelin.…”

Section: Resultsmentioning

confidence: 99%

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Thermodynamic equation of state for cholesteryl esters in surface phases

Jm¹,

Hl²

1984

Biochemistry

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Phase behavior at the air-water interface for binary mixtures of cholesteryl esters with several phospholipids was determined and combined with a large body of data from other similar studies. Analysis of areas along the phase boundary between the monolayer phase and either a double layer or a bulk phase revealed a simple, additive relationship between lipid components. This indicates that at its limits the monolayer phase behaves as an ideal mixture of components with fixed partial molecular areas. This concept is supported by the independence of the values of the partial molecular areas from the nature of the other lipid component. General agreement with the model was also found for data from the double-layer-bulk phase boundary. However, in contrast to the monolayer phase boundary, the double-layer phase behaves as if comprised of components with not only fixed but also identical partial molecular areas. The lack of a surface pressure dependency for partial molar areas apparently contradicts earlier thermodynamic descriptions of surfaces. However, satisfactory resolution with theory can be obtained if along the phase boundary each lipid species has a stoichiometric number of water molecules associated with it. This concept is supported by the consistency and values of the parameters calculated from the data by using this model. In both phases, the activity coefficient of interfacial water was constant, and the cholesteryl esters were relatively more hydrated than the other lipids. Overall, this thermodynamic equation of state for phase boundaries provides the basis for modeling the surfaces of natural, cholesteryl ester rich lipid inclusions like lipoproteins and arterial lipid deposits.

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Section: Resultssupporting

confidence: 72%

Section: Resultsmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 86%

Section: Resultsmentioning

confidence: 99%

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Thermodynamic equation of state for cholesteryl esters in surface phases

Jm¹,

Hl²

1984

Biochemistry

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“…Instead, it forms multilayer patches immediately after spreading which transform into a continuous duplex film at further compression. Pure SO film was in monolayer state up to 84 Å 2 and at further compression a multilayered structure is adopted as reported for other surface films by plant oils and other triacylglycerol rich mixtures [17,18].…”

Section: Alternating Mgs Amount In the Film-forming Solutions Of The ...mentioning

confidence: 99%

Surface Chemistry Study of the Interactions of Sesame Oil with Meibomian Films

2022

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A possible approach for the treatment of meibomian gland disease (MGD) can be the supplementation of meibomian gland secretion (MGS) with nonpolar lipids (NPL) rich plant oils. Sesame oil (SO), approximately equal in monounsaturated fat (oleic acid, 40% of total) and polyunsaturated fat (linoleic acid, 42% of total), has shown multiple health benefits due to its anti-inflammatory and antioxidant effects. Thus, the interactions between SO and MGS in surface layers deserve further study. Therefore, pseudobinary films were formed with controlled MGS/SO molar ratios (0%, 10%, 30%, 50%, and 100% SO) at the air/water surface of the Langmuir trough over phosphate buffered saline (pH 7.4) subphase. Surface pressure (π)-area (A) isotherms and Brewster angle microscopy observations showed nonideal interactions where SO aggregates with MGS and complements the NPL stratum of the meibomian layers. The analysis of stress relaxation transients with Kohlrausch–Williams–Watts equation revealed that the supplementation of fixed amount of MGS with excess lipids via SO altered the dilatational elasticity of the films as reflected by the increase of the exponent β. Thus, SO with its unique combination of high oxidative stability and abundance of long polyunsaturated acyl chains might be a useful supplement to MGS layers.

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Lipid Droplet Surface Promotes 3D Morphological Evolution of Non‐Rhomboidal Cholesterol Crystals

Lee,

Kang,

Choi

2024

Advanced Science

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Cholesterol crystals, which cause inflammation and various diseases, predominantly grow in a platy, rhomboid structure on the plasma membranes but exhibit an uneven three‐dimensional (3D) architecture intracellularly. Here, it is demonstrated how cholesterol crystallizes in a non‐rhomboidal shape on the surface of lipid droplets and develops into 3D sheet‐like agglomerates using an in vitro lipid droplet reconstitution system with stereoscopic fluorescence imaging. The findings reveal that interfacial cholesterol transport on the lipid droplet surface and unique lipid droplet components significantly influence the nucleation‐and‐growth dynamics of cholesterol crystals, leading to crystal growth in various polygonal shapes. Furthermore, cholesterol crystals readily agglomerate to form large, curved sheet structures on the confined, spherical surfaces of lipid droplets. This discovery enhances the understanding of the volumetric morphological growth of intracellular cholesterol crystals.

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Lipid structure and the behavior of cholesteryl esters in monolayer and bulk phases.

Cited by 31 publications

References 14 publications

Thermodynamic equation of state for cholesteryl esters in surface phases

Thermodynamic equation of state for cholesteryl esters in surface phases

Surface Chemistry Study of the Interactions of Sesame Oil with Meibomian Films

Lipid Droplet Surface Promotes 3D Morphological Evolution of Non‐Rhomboidal Cholesterol Crystals

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