Lipid transfer to high‐density lipoproteins in coronary artery disease patients with and without previous cerebrovascular ischemic events

Barbosa, Camila de Souza; Maranhão, Raul C.; Barreiros, Renata S.; Freitas, Fatima R.; Franci, André; Strunz, Celia Maria Cassaro; Arantes, Flávia Bittar Britto; Tavoni, Thauany Martins; Ramires, José A. F.; Filho, Roberto Kalil; Nicolau, José Carlos

doi:10.1002/clc.23259

Cited by 7 publications

(10 citation statements)

References 42 publications

(74 reference statements)

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“…Increased HDL levels can prevent coronary artery disease. 30,39) In conclusion, due to the interaction between decreased HDL-C and increased CRP in CAD, increased CHR may be associated with inflammatory activity and dyslipidemia. Furthermore, a comprehensive CHR indicator may be more effective and reliable than a single indicator in explaining the complex interactions between CRP and HDL-C. To the best of our knowledge, there is no study yet discussing the relationship between CHR and the severity of CAD.…”

Section: Discussionmentioning

confidence: 93%

“…27) HDL-C, as a typical lipid-related biomarker, plays an important protective role in the process of atherosclerosis and inflammation owing to its antioxidant, anti-inflammatory, anti-apoptotic, and antithrombotic properties. [28][29][30] HDL-C has been shown to regulate cholesterol efflux, protect vascular endothelium, stabilize plaque, and prevent rupture. [31][32][33] In addition, HDL reduces inflammation by inhibiting the expression of adhesion molecules in the endothelial cells and reduces coronary atherosclerosis by inhibiting the oxidation of LDL.…”

Section: Discussionmentioning

confidence: 99%

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High-Sensitivity C-Reactive Protein to HDL-C Ratio

2021

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

High-Sensitivity C-Reactive Protein to HDL-C Ratio

2021

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“…Therefore, recent studies on the correlation between lipid biomarkers and coronary heart disease have become the focus 21 . HDL-C, as a typical lipid related biomarker, plays an important protective role in the process of atherosclerosis and in ammation due to its anti-oxidant, anti-in ammatory, anti-apoptotic and anti-thrombotic properties [22][23][24] . HDL-C has been shown to regulate cholesterol e ux, protect vascular endothelium, stabilize plaque, and prevent rupture [25][26][27] .…”

Section: Discussionmentioning

confidence: 99%

“…It had been estimated that for each increment of 1 mg/dL in HDL-C, the CAD risk was reduced by 2% in males and by 3% in females 31,32 . Current evidence suggested an inverse correlation between HDL-C levels and CAD, myocardial infarction, carotid atherosclerosis, and stroke.Increased HDL levels can prevent coronary heart disease 24,33 .…”

Section: Discussionmentioning

confidence: 99%

Hypersensitive C-reactive Protein to HDL-C Ratio Predicts the Severity of Coronary Artery Disease

Luo¹,

Kou²,

Yin³

2020

Preprint

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Background: Lipid and inflammatory molecules play a key role in the development of coronary atherosclerosis. Hypersensitive C-reactive proteins are used as markers of inflammation duration, and HDL-C is used as an anti-atherosclerosis component. However, few studies have combined the two indicators to explore coronary stenosis. We suggested that Hypersensitive C-reactive proteins as a marker of inflammation persistence and HDL-C as an anti-atherosclerosis component should be integrated into a single biomarker , so as to explore the correlation of Hypersensitive C-reactive protein HDL-C ratio with the severity of coronary stenosis and to predict the severity of coronary stenosis in CAD patients.Methods: We examined 360 eligible patients who underwent coronary angiography. Based on the results of coronary angiography, patients with any major coronary arteries (the left anterior descending artery, the left circumflex artery, the left main coronary artery, the right coronary artery) whose lumen diameter reduced by more than 50% were defined as CAD + group (n = 139) .Patients with luminal stenosis but no more than 50% were defined as CAD- group (n = 41), and patients without luminal stenosis (n = 180) were regarded as control group. The relationship between various serum markers and the severity of coronary stenosis was examined by Spearman correlation analysis. Logistic regression analysis was performed to identify the influencing factors of the severity of coronary artery disease.Results: The modified Gensini score was positively correlated with Hypersensitive C-reactive protein HDL-C ratio . Multiple regression analysis showed that Hypersensitive C-reactive protein HDL-C ratio were significantly associated with CAD. Hypersensitive C-reactive protein HDL-C ratio is an independent predictor of CAD. The ROC analysis provided a cut-off value of 1.17 for Hypersensitive C-reactive protein HDL-C ratio to predict CAD with 83.9% specificity and 0.242 Yoden index, and area under the ROC curve of 0.632 (95%CI 0.571-0.694, P <0.001).At the same time, the area under the ROC curve of Neutrophil HDL-C ratio was 0.620, indicating that Hypersensitive C-reactive protein HDL-C ratio as a predictor of CAD has better diagnostic performance than Neutrophil HDL-C ratio.Conclusion: Hypersensitive C-reactive protein HDL-C ratio is not only closely related to coronary artery stenosis, but also an independent predictor of severe coronary stenosis.

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“…7,8 This assay was reported as an important tool for the assessment of cardiovascular risk in other diseases, such as premature CAD (coronary artery disease) 9 and ischemic cerebrovascular events (ICVE). 10…”

Section: Introductionmentioning

confidence: 99%

Hydroxychloroquine increased cholesterol transfer to high-density lipoprotein in systemic lupus erythematosus: A possible mechanism for the reversal of atherosclerosis in the disease

Lang

Vinagre

Bonfá

et al. 2022

Lupus

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Introduction The beneficial effect of hydroxychloroquine (HCQ) in decreasing LDL levels on Systemic Lupus Erythematosus (SLE) is well defined. The influence of this drug on HDL levels is still under debate and information about its effect on cholesterol reverse transport is lacking. Objective To evaluate the effects of HCQ on HDL levels and the transfer of lipids to this lipoprotein in SLE. Methods Nineteen SLE patients using only HCQ (SLE WITH HCQ), 19 SLE patients without any therapy (SLE WITHOUT THERAPY), and 19 healthy controls (CONTROL) were included. All three groups were premenopausal women age- and gender-matched. Serum lipids and apolipoproteins were determined by commercial kits. An in vitro transfer of four lipids (14C-Phospolipid, 3H-Cholesteryl ester, 3H-Triglyceride, and 14C-Unesterified cholesterol) from a radioactively labeled nanoemulsion donor to HDL was performed in all participants. Results Groups had comparable mean age, weight, height, BMI(body mass index), and waist circumference ( p > .05). Mean HDL levels were higher in SLE WITH HCQ group compared to SLE WITHOUT THERAPY(58.37 ± 14.04 vs 49.79 ± 8.0 mg/dL; p < .05) but lower than CONTROL (58.37 ± 14.04 vs 68.58 ± 9.99 mg/dL; p < .05). Total cholesterol (TC) and LDL levels were also significantly lower in SLE WITH HCQ compared SLE WITHOUT THERAPY(148.16 ± 16.43 vs 167.11 ± 30.18 mg/dL; p < .05, 75.05 ± 22.52 vs 96.05 ± 25.63 mg/dL; p < .05) and CONTROL (148.16 ± 16.43 vs 174.11 ± 23.70 mg/dL; p < .05, 75.05 ± 22.52 vs 88.53 ± 20.24 mg/dL; p < .05). The in vitro lipid transfer to HDL study revealed a significant difference among the three groups ( p = .002) with a higher transfer of unesterified cholesterol(UC) in SLE WITH HCQ compared to SLE WITHOUT THERAPY(5.40 ± 1.05% vs. 4.44 ± 1.05%; p < .05). The latter was significantly decreased compared to CONTROL (5.40 ± 1.05% vs. 5.99 ± 1.71%; p < .05).The percentages of transfer of triacylglycerol (4.93 ± 0.69% vs. 4.50 ± 0.69% vs. 5.14 ± 1.01%; p = .054), esterified cholesterol (5.24 ± 0.70% vs. 4.96 ± 0.89% vs. 5.69 ± 1.27%; p = .079), and phospholipid (15.67 ± 1.03% vs. 15.34 ± 1.44% vs. 16.47 ± 1.89%; p = .066) were similar among groups. Conclusion The present study is the first to demonstrate that HCQ promoted a higher transfer of unesterified cholesterol which may account for the increased HDL levels in lupus patients under HCQ. This desirable effect may underlie the reported reduced atherosclerosis in SLE.

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Lipid transfer to high‐density lipoproteins in coronary artery disease patients with and without previous cerebrovascular ischemic events

Cited by 7 publications

References 42 publications

High-Sensitivity C-Reactive Protein to HDL-C Ratio

High-Sensitivity C-Reactive Protein to HDL-C Ratio

Hypersensitive C-reactive Protein to HDL-C Ratio Predicts the Severity of Coronary Artery Disease

Hydroxychloroquine increased cholesterol transfer to high-density lipoprotein in systemic lupus erythematosus: A possible mechanism for the reversal of atherosclerosis in the disease

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