Lipidomics applications in health, disease and nutrition research

Abstract

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Lipidomics

“…In the past 10 years, lipidomics has emerged as a new field in systems biology and has increased interest in disease diagnosis and biomarker discovery (obesity, diabetes, cardiovascular disease, Alzheimer's disease, pancreatic cancer, etc. ), pharmaceutical discovery and development, human food and nutrition research [49][50][51][52][53][54][55]. This powerful approach can reveal unique metabolic characteristics of normal, pathologic, or treatment-specific events.…”

Mass spectrometry analysis of blood plasma lipidome as method of disease diagnostics, evuation of effectiveness and optimization of drug therapy

“…Липиды интегрированы практически во все процессы, протекающие в организме человека. Они выполняют структурные функции (формируют мембраны), обеспечивают окружение гидрофобным белкам, выполняют транспортную функцию для липофильных веществ, принимают активное участие в энергетическом обмене, выступая в роли источника энергии, являются гормонами и вторичными мессенджерами [9][10][11]. Широкое вовлечение липидов в биохимические процессы организма объясняет их связь с воздействующими на организм внешними факторами и протекающими в организме различного рода патологическими процессами.…”

Assessment of different sample preparation routes for mass spectrometric monitoring and imaging of lipids in bone cells via ToF-SIMS

“…1 This complexity accounts for the involvement of lipids not only in obvious functions such as energy storage and the formation of lipid membranes, but also in a variety of homeostatic processes and disease states. [1][2][3] On cellular level, lipids act as cell signaling molecules and are involved in the regulation of various cellular functions such as proliferation, apoptosis, inflammation, immunity, and even DNA modulation.…”

“…1 This complexity accounts for the involvement of lipids not only in obvious functions such as energy storage and the formation of lipid membranes, but also in a variety of homeostatic processes and disease states. [1][2][3] On cellular level, lipids act as cell signaling molecules and are involved in the regulation of various cellular functions such as proliferation, apoptosis, inflammation, immunity, and even DNA modulation. 4 Lipids and their metabolism affect pathological processes like atherosclerosis, 5 osteoporosis, 6 cancer, 7 and diabetes 8 and are of potential value as novel biomarkers for such diseases on the one hand and for cellular processes like chondrogenesis, 9 on the other hand.…”

“…10 However, complete cellular lipid profiles, "lipidomes", cannot be analyzed with a single experimental approach and are analytically demanding. 1,11,12 At present, only a limited number of studies focus on systematic SIMS characterization and imaging of lipids in complex biological samples, compare (Ref. 13).…”