Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences

Yang, Kui; Han, Xianlin

doi:10.1016/j.tibs.2016.08.010

Cited by 468 publications

(402 citation statements)

References 143 publications

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“…To date, lipidomic analytical strategies are applied to a wide variety of biological samples such as blood, plasma, serum, cerebrospinal fluid, urine and biological tissue derived from animal models or clinical patients [30]. The choice of the most appropriate analytical technique is based on the characteristics of the biological sample and the chemical properties of the targeted lipids.…”

Section: Analytical Technology In Lipidomicsmentioning

confidence: 99%

Advances in Lipidomics for Cancer Biomarkers Discovery

Perrotti

Rosa

Cicalini

et al. 2016

IJMS

164

119

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Lipids play critical functions in cellular survival, proliferation, interaction and death, since they are involved in chemical-energy storage, cellular signaling, cell membranes, and cell–cell interactions. These cellular processes are strongly related to carcinogenesis pathways, particularly to transformation, progression, and metastasis, suggesting the bioactive lipids are mediators of a number of oncogenic processes. The current review gives a synopsis of a lipidomic approach in tumor characterization; we provide an overview on potential lipid biomarkers in the oncology field and on the principal lipidomic methodologies applied. The novel lipidomic biomarkers are reviewed in an effort to underline their role in diagnosis, in prognostic characterization and in prediction of therapeutic outcomes. A lipidomic investigation through mass spectrometry highlights new insights on molecular mechanisms underlying cancer disease. This new understanding will promote clinical applications in drug discovery and personalized therapy.

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Section: Analytical Technology In Lipidomicsmentioning

confidence: 99%

Advances in Lipidomics for Cancer Biomarkers Discovery

Perrotti

Rosa

Cicalini

et al. 2016

IJMS

164

119

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“…Lipidomics and proteomics use mass spectrometry to identify and quantify lipid and protein content in a cell, tissue or organ, respectively [77–79]. These methods involve the use of complex technology in several research settings and may even help determine typical and abnormal lipoprotein composition [80, 81].…”

Section: Introductionmentioning

confidence: 99%

Impact of menopause and diabetes on atherogenic lipid profile: is it worth to analyse lipoprotein subfractions to assess cardiovascular risk in women?

Fonseca

Silva

Ferreira

2017

Diabetol Metab Syndr

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Cardiovascular disease is the leading cause of death in women at advanced age, who are affected a decade later compared to men. Cardiovascular risk factors in women are not properly investigated nor treated and events are frequently lethal. Both menopause and type 2 diabetes substantially increase cardiovascular risk in the female sex, promoting modifications on lipid metabolism and circulating lipoproteins. Lipoprotein subfractions suffer a shift after menopause towards a more atherogenic lipid profile, consisted of hypertriglyceridemia, lower levels of both total high density lipoprotein (HDL) and its subfraction HDL2, but also higher levels of HDL3 and small low-density lipoprotein particles. This review discusses the impact of diabetes and menopause to the lipid profile, challenges in lipoprotein subfractions determination and their potential contribution to the cardiovascular risk assessment in women. It is still unclear whether lipoprotein subfraction changes are a major driver of cardiometabolic risk and which modifications are predominant. Prospective trials with larger samples, methodological standardizations and pharmacological approaches are needed to clarify the role of lipoprotein subfractions determination on cardiovascular risk prediction and intervention planning in postmenopausal women, with or without DM.

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“…The key features, advantages, and limitations of these MS technologies were summarized in the review of Yang et al. . When shotgun lipidomics are performed on a tandem MS, the method makes use of precursor ions, product ions and neutral loss scans to identify the specific lipid class of the sample.…”

Section: Ms‐based Analytical Techniques In Lipidomicsmentioning

confidence: 99%

Mass‐spectrometry‐based lipidomics

Zhang

2017

J of Separation Science

128

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Lipids, which have a core function in energy storage, signalling and biofilm structures, play important roles in a variety of cellular processes because of the great diversity of their structural and physiochemical properties. Lipidomics is the large-scale profiling and quantification of biogenic lipid molecules, the comprehensive study of their pathways and the interpretation of their physiological significance based on analytical chemistry and statistical analysis. Lipidomics will not only provide insight into the physiological functions of lipid molecules but will also provide an approach to discovering important biomarkers for diagnosis or treatment of human diseases. Massspectrometry-based analytical techniques are currently the most widely used and most effective tools for lipid profiling and quantification. In this review, the field of massspectrometry-based lipidomics was discussed. Recent progress in all essential steps in lipidomics was carefully discussed in this review, including lipid extraction strategies, separation techniques and mass-spectrometry-based analytical and quantitative methods in lipidomics. We also focused on novel resolution strategies for difficult problems in determining C=C bond positions in lipidomics. Finally, new technologies that were developed in recent years including single-cell lipidomics, flux-based lipidomics and multiomics technologies were also reviewed.

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Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences

Cited by 468 publications

References 143 publications

Advances in Lipidomics for Cancer Biomarkers Discovery

Advances in Lipidomics for Cancer Biomarkers Discovery

Impact of menopause and diabetes on atherogenic lipid profile: is it worth to analyse lipoprotein subfractions to assess cardiovascular risk in women?

Mass‐spectrometry‐based lipidomics

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