Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis

Quintana, Francisco J.; Yeste, Ada; Weiner, Howard L.; Covacu, Ruxandra

doi:10.1016/j.jneuroim.2012.01.002

Cited by 45 publications

(40 citation statements)

References 73 publications

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“…The recently identified antibody against the potassium channel protein KIR4.1, for example, is detectable in not even 50% of MS patients [57]. In summary: No highly MS specific antigen or autoantibody signature could be identified yet [42,[58][59][60][61][62].…”

Section: Biomarker Candidates In the Central Nervous Systemmentioning

confidence: 97%

Molecular Biomarkers in Multiple Sclerosis

Paap

Hecker²,

Koczan³

et al. 2013

J Clin Cell Immunol

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Multiple Sclerosis (MS) is a chronic immune-modulated disorder of the central nervous system (CNS) affecting mainly young adults. Due to the complexity and heterogenic etiology of this disease diagnosis, treatment, and estimations concerning the future course of the disease for the individual patient are challenging. To encounter the variability in phenotype, disease progression and response to treatments, various new drugs are in development to complement existing treatment options. Since years intensive efforts are directed to identify biomarkers that are associated with various aspects of MS on different levels of the organizational hierarchy of the human body (e.g. DNA, RNA, proteins, cells).We researched the last ten years of literature to identify those proposed candidates that had been repeatedly published as being associated with MS etiology, clinical manifestation, disease course, and treatment response.Here, we present a categorized overview over molecular biomarkers in MS.However, despite of the large sum of studies and the long list of candidate markers, today only very few biomarkers are of clinical value. This is mostly due to lack of comparability and statistical power in most studies. However, there are recent advances in the field of applicable molecular biomarkers in MS: For example measurement of anti-AQP4 levels allows differentiation between neuromyelitis optica (NMO) and MS.

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Section: Biomarker Candidates In the Central Nervous Systemmentioning

confidence: 97%

Molecular Biomarkers in Multiple Sclerosis

Paap

Hecker²,

Koczan³

et al. 2013

J Clin Cell Immunol

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“…Lipids are also important targets of the autoimmune response in MS (69 ). To investigate the immune response to lipids in MS, Kanter et al developed microarrays of lipids present in the myelin sheath, including ganglioside, sulfatide, cerebroside, sphingomyelin, and total brain lipid fractions (13 ).…”

Section: Multiple Sclerosismentioning

confidence: 99%

Antigen Microarrays for the Study of Autoimmune Diseases

Yeste

Quintana

2013

Clinical Chemistry

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BACKGROUND The immune response involves the activation of heterogeneous populations of T cells and B cells that show different degrees of affinity and specificity for target antigens. Although several techniques have been developed to study the molecular pathways that control immunity, there is a need for high-throughput assays to monitor the specificity of the immune response. CONTENT Antigen microarrays provide a new tool to study the immune response. We reviewed the literature on antigen microarrays and their advantages and limitations, and we evaluated their use for the study of autoimmune diseases. Antigen arrays have been successfully used for several purposes in the investigation of autoimmune disorders: for disease diagnosis, to monitor disease progression and response to therapy, to discover mechanisms of pathogenesis, and to tailor antigen-specific therapies to the autoimmune response of individual patients. In this review we discuss the use of antigen microarrays for the study of 4 common autoimmune diseases and their animal models: type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis. CONCLUSIONS Antigen microarrays constitute a new tool for the investigation of the immune response in autoimmune disorders and also in other conditions such as tumors and allergies. Once current limitations are overcome, antigen microarrays have the potential to revolutionize the investigation and management of autoimmune diseases.

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Section: Introductionmentioning

confidence: 99%

“…Lipids and related antibodies even could be considered biomarkers during the monitoring of disease progression and evaluation effects of treatment in MS [6] . Total cholesterol (TC) is an essential component of compact myelin and associated with membranes of astrocytes and neurons [6,7] . Triglyceride (TG) could cause vascular endothelial dysfunction and inflammation by affecting the expression of multiple proinflammatory, procoagulant, and proapoptotic genes [8] .…”

Section: Introductionmentioning

confidence: 99%

Elevated Lipid Profiles in Patients with Acute Transverse Myelitis

Liu

Li²,

Wang³

et al. 2016

Eur Neurol

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Background: The associations and clinical relevance of serum lipid profiles in patients with acute transverse myelitis (ATM) are unknown. Our study aimed at investigating the status of serum lipid variables (including total cholesterol (TC), triglycerides (TGs), high/low density lipoproteins (HDL/LDL), apolipoprotein A-I (ApoA-I), apolipoprotein B (ApoB) and cholesterol to HDL ratio) in ATM, and to explore whether there was a correlation between serum lipid levels and disease characteristics of ATM. Methods: We retrospectively evaluated serum lipid levels of 92 patients with ATM, 43 with multiple sclerosis (MS) on relapse and 112 healthy controls (HC). The changes of serum lipid profiles were analyzed. Results: We found that ATM patients had higher serum TC, TG, LDL levels and T/H ratio than HC, but had lower levels of serum ApoA-I and ApoB. Besides, there were no significant differences between ATM and MS on relapse (except ApoB). Third, longer disease duration was associated with higher TG; higher HDL was associated with a trend for lower Expanded Disability Status Scale scores. Conclusions: Our findings showed that serum lipid levels were elevated in patients with ATM, among serum TG and HDL might be associated with clinical features. These results illustrate that a long-term follow-up and regular monitoring of serum lipid profiles are important for ATM patients.

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Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis

Cited by 45 publications

References 73 publications

Molecular Biomarkers in Multiple Sclerosis

Molecular Biomarkers in Multiple Sclerosis

Antigen Microarrays for the Study of Autoimmune Diseases

Elevated Lipid Profiles in Patients with Acute Transverse Myelitis

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