Lipids and Lipoproteins in Health and Disease

Bezsonov, Evgeny E.; Sobenin, Igor A.; Orekhov, Alexander N.

doi:10.3390/biomedicines10010087

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…This favors the production of antiangiogenic factors into maternal circulation that contributes to endothelial damage. Previous study have shown that increased concentrations of antiangiogenic substances including soluble endoglin (sEng) and tyrosine kinase-1 (sFlt-1) 6 produced by the placenta into the mother's bloodstream during preeclampsia promote endothelial dysfunction and proteinuria 7 .…”

Section: Introductionmentioning

confidence: 99%

Comparative study of lipoprotein lipase enzyme, ApoE and ApoC2, in pregnant women with and without preeclampsia

Kadhim

AL-Smaism

Al-Hilli

2022

ijhs

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Background: Preeclampsia (PE) is a multisystemic syndrome specific to pregnancy. Although PE is the most common cause of death from pregnancy-related problems, its underlying cause is still unknown. In PE, lipid metabolism is altered. When lipids are damaged, both the mother and the foetus may be at risk. Methods: Blood samples were taken from 45 normotensive and 45 preeclamptic pregnant women. These samples were analyzed for LPL, Apo E and C2. Results: Concentrations of LPL, Apo C2 and Apo E differ significantly between preeclamptic women and pregnant controls which were higher in preeclamptic than in pregnant controls. Conclusions: In preeclamptic women, the increase in LPL, ApoC2 and Apo E concentration may serve as a marker for preeclampsia complication that which leads to worse consequences and could be a relevant factor in the pathogenesis of preeclampsia.

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Section: Introductionmentioning

confidence: 99%

Comparative study of lipoprotein lipase enzyme, ApoE and ApoC2, in pregnant women with and without preeclampsia

Kadhim

AL-Smaism

Al-Hilli

2022

ijhs

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“…Among the modifications of LDL which have been studied are oxidation [15], and desialylation [16]. HDL is involved in the transport of cholesterol from the arterial wall, playing an important role in regulating lipid levels with the low level of HDL that is connected with atherosclerosis development [17].…”

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confidence: 99%

Lipids and Lipoproteins in Atherosclerosis

et al. 2023

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Effects of Lipoproteins on Metabolic Health

Albitar,

D’Souza,

Adeghate

2024

Nutrients

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Lipids are primarily transported in the bloodstream by lipoproteins, which are macromolecules of lipids and conjugated proteins also known as apolipoproteins. The processes of lipoprotein assembly, secretion, transportation, modification, and clearance are crucial components of maintaining a healthy lipid metabolism. Disruption in any of these steps results in pathophysiological abnormalities such as dyslipidemia, obesity, insulin resistance, inflammation, atherosclerosis, peripheral artery disease, and cardiovascular diseases. By studying these genetic mutations, researchers can gain valuable insights into the underlying mechanisms that govern the relationship between protein structure and its physiological role. These lipoproteins, including HDL, LDL, lipoprotein(a), and VLDL, mainly serve the purpose of transporting lipids between tissues and organs. However, studies have provided evidence that apo(a) also possesses protective properties against pathogens. In the future, the field of study will be significantly influenced by the integration of recombinant DNA technology and human site-specific mutagenesis for treating hereditary disorders. Several medications are available for the treatment of dyslipoproteinemia. These include statins, fibrates, ezetimibe, niacin, PCSK9 inhibitors, evinacumab, DPP 4 inhibitors, glucagon-like peptide-1 receptor agonists GLP1RAs, GLP-1, and GIP dual receptor agonists, in addition to SGLT2 inhibitors. This current review article exhibits, for the first time, a comprehensive reflection of the available body of publications concerning the impact of lipoproteins on metabolic well-being across various pathological states.

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Lipids and Lipoproteins in Health and Disease

Abstract: This Special Issue, “Lipids and Lipoproteins in Health and Disease: Focus on Targeting Atherosclerosis”, contains research articles and reviews devoted to the study of lipids in different processes, with a focus on the pathological changes that happen during atherosclerosis [...]

Cited by 3 publications

References 25 publications

Comparative study of lipoprotein lipase enzyme, ApoE and ApoC2, in pregnant women with and without preeclampsia

Comparative study of lipoprotein lipase enzyme, ApoE and ApoC2, in pregnant women with and without preeclampsia

Lipids and Lipoproteins in Atherosclerosis

Effects of Lipoproteins on Metabolic Health

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