Lipids and Lipoproteins in Subjects at 1,000 and 3 ,500 Meter Altitudes

Mendoza, Soaira; Nucete, H.; Ineichen, Emilio; Salazar, Enrique Gonzalo Rojas; Zerpa, A.; Glueck, Charles J.

doi:10.1080/00039896.1979.10667422

Cited by 34 publications

(21 citation statements)

References 13 publications

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“…Additionally, lipid metabolism in humans has been shown to be altered with exposure to high altitude (15,16). Acclimatization to high altitude led to increased circulating triglyceride levels and reduced or unchanged plasma cholesterol concentration as reported by Young et al (17), which partly corroborate with our finding, whereby the O S population has reduced cholesterol level but not triglyceride.…”

Section: Resultssupporting

confidence: 91%

Moderately high altitude habitation modulates lipid profile and alkaline phosphatase activity in aged Khasis of Meghalaya

Ranhotra¹,

Sharma²

2010

Indian J Clin Biochem

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Section: Resultssupporting

confidence: 91%

Moderately high altitude habitation modulates lipid profile and alkaline phosphatase activity in aged Khasis of Meghalaya

Ranhotra¹,

Sharma²

2010

Indian J Clin Biochem

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“…The triglyceride and C-HDL differences across cultures cannot be accounted for by differing laboratory methodology, subject selection, or sampling iechniqu& (time of fasting) because these were similar or identical in the two hpulations sGdied. The etiology of this difference is unknown but is consistent with out findings of lower C-HDL and higher triglyceride levels in Venezuelan adults (from the Merida locale) as cornpared to Cincinnati adults (12).…”

Section: Discussionsupporting

confidence: 66%

Lipids and Lipoproteins in Venezuelan and American Schoolchildren: Within and Cross-Cultural Comparisons

et al. 1980

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This study was designed to focus upon within-culture differences in plasma lipids and lipoproteins in Venezuelan schookhildren having different socioeconomic and nutritional backgrounds and also to provide crosscultural comparisons of lipids, lipoproteins, and anthropometric measurements between Venezuelan and American schoolchildren. The study was carried out in 12!M schoolchildren, ages 7 to 12 years, 428 in private and 870 in public schools in Merida, Venezuela, with comparison to 472 public schoolchildren in the (Cincinnati, OH) Princeton School District. Within Venezuelan schools, private schoolchildren were heavier, taller, had marginally higher Qwtelet indices, and had considerably higher fasting plasma cholesterol, plasma highdensity lipoprotein (C-HDL), and plasma lowdensity lipoprotein (C-LDL) levels. These lipid-lipoprotein differences were highly significant after adjusting (by covariance analysis) for Quetelet index, sex, and age. Children from private Venezuelan schools ingested more total calories, more protein, more fat, and more carbohydrate.When the diet compositions were calculated as percentage of total calories, the private schookhildren ingested nearly twice as many calories as fat and a somewhat lower wmortion of calories as carbohydrate, with a comparable prob&n as protein, when compared to the public Venezuelan schoolchildren. Male-female comparisons within Venezuelan schools revealed patterns of sexrelated lipoprotein differences which were qualitatively similar to those in Princeton schookhildren. Thus, 7-to 12-year-old females had higher total plasma cholesterol and triglyceride, lower C-HDL, and higher C-LDL. Within sex, crosscultural comparisons of lipids, lipoproteins, and Quetelet indices revealed two major differences. Venezuelan children had sigoifkantly higher fasting plasma triglyceride and lower C-HDL levels, differences not attributable to systematic dmerences in measures of ponderosity, because Quetelet indices in Venezuelan and Cincinnati schoolchildren did not differ appreciably. In regard to total and lowdensity lipoprotein cholesterol, Venezuelan and Princeton p u b schoolchildren were remarkably comparable, although Venezuelan private schoolchildren had somewhat higher plasma cholesterol and C-LDL levels than did Princeton public schoolchildren. We speculate that increasing "westernization" and "urbanization" of Venezuelan society is associated with convergence of Venezuelan and American pediatric plasma lipid and lipoprotein levels. Maintenance of comparable total plasma cholesterol and C-LDL levels with lower C-HDL into adulthood in Venezuela would, in fact, suggest augmented risks for coronary heart disease for Venezuela within this lipid-lipoprotein frame of reference. SpeculationWe speculate that increasing "westernization" and "urbanization" of Venezuelan society is associated with convergence of 2

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“…The analysis revealed a higher prevalence of hypertension, obesity, and hypercholesterolemia in highaltitude living elders compared with those living in low-altitude areas. Despite the lack of previous findings regarding altitude and prevalence of the metabolic syndrome, a number of studies have already investigated cardiometabolic risk factors in different geographic areas worldwide, comparing high-vs. low-altitude adult residents, and showing similar results [8,9,[11][12][13][14][15][16][17][18][19]. Some health conditions have been proposed to explain the accumulation of these metabolic risk factors among individuals living at high altitudes like acute mountain sickness, high-altitude pulmonary edema, high-altitude cerebral edema, hypoxia, lack of appetite, tiredness, stomach upset, and disinclination to work.…”

Section: Discussionsupporting

confidence: 50%

“…Some of these studies reported that the prevalence of hypertension at high-altitude residents was lower than in low-altitude ones [10][11][12]. Furthermore, cholesterol levels decreased with increasing altitude, whereas high-density lipoprotein cholesterol seemed to be increased [11,[13][14][15][16]. However, other studies reported opposite results, according to which high-altitude living was associated with elevated blood pressure and increased risk of atherosclerotic disease [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Health Care Access and Prevalence of the Metabolic Syndrome Among Elders Living in High-Altitude Areas of the Mediterranean Islands: The MEDIS Study

et al. 2011

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■ Abstract AIM:The aim of the present work was to evaluate the relationships between sociodemographic, clinical, and lifestyle characteristics and the presence of metabolic syndrome, among high and low altitude living elderly individuals without known CVD. METHODS: During 2005During -2011During , 1959 elderly (aged 65 to 100 years) individuals from 13 Mediterranean islands were enrolled. Sociodemographic, clinical, and lifestyle factors were assessed using standard procedures. Metabolic syndrome was defined according to the (Adult Treatment Panel) ATP III criteria. Mountainous areas were defined those more than 400 meters in height. RESULTS: For the present analysis 713 men and 596 women were studied; the prevalence of the metabolic syndrome was 29% (24% in men, 35% in women, p < 0.001). Furthermore, the prevalence of metabolic syndrome was 55% in the elders living in mountainous areas, as compared with 26% among those living at sea-level (p = 0.01). Similarly, the prevalence of hypertension, hypercholesterolemia, and obesity were higher in high altitude as compared with low altitude areas (all pvalues < 0.01). After adjusting for various confounders, elders living in high altitude areas were 3.06-times more likely to have the metabolic syndrome than those living at sea-level (OR = 3.06, 95%CI 2.02-4.65). However, when the annual number of visits to health care centers was taken into account, the effect of altitude of living was not associated with the presence of the syndrome. CONCLUSIONS: A considerable proportion of mountainous living elderly had the metabolic syndrome. Public health actions need to be taken to reduce the burden of cardiometabolic disorders by enabling better access to health care, especially in remote mountainous rural areas.

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Lipids and Lipoproteins in Subjects at 1,000 and 3 ,500 Meter Altitudes

Cited by 34 publications

References 13 publications

Moderately high altitude habitation modulates lipid profile and alkaline phosphatase activity in aged Khasis of Meghalaya

Moderately high altitude habitation modulates lipid profile and alkaline phosphatase activity in aged Khasis of Meghalaya

Lipids and Lipoproteins in Venezuelan and American Schoolchildren: Within and Cross-Cultural Comparisons

Health Care Access and Prevalence of the Metabolic Syndrome Among Elders Living in High-Altitude Areas of the Mediterranean Islands: The MEDIS Study

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