Lipids in serum of patients with malignant ovarian neoplasms

Gadomska, Halina; Janecki, J; Marianowski, L; Nowicka, Grażyna

doi:10.1016/s0020-7292(97)00071-4

Cited by 23 publications

(15 citation statements)

References 16 publications

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“…The conventional purpose of HDL involves the assemblage of cholesterol from peripheral tissues for transportation to the liver for the purpose of excretion [37]. In tandem with our findings, Gadomska et al [18] in a multidimensional analysis established lower concentrations of HDL sub-fractions of total cholesterol and esterified cholesterol significantly discriminated women with ovarian neoplasm. It is plausible that HDL (more than LDL) perhaps is the focal driver of the TC-OT risk link given the absence of an association between LDL and OT risk.…”

Section: Discussionsupporting

confidence: 87%

“…Of the 1619 records obtained from the primary literature search, 377 duplicates and 1079 records were excluded after examining titles and abstracts. Also, 151 records were excluded after full-text evaluation and 12 studies [6][7][8][9][10][16][17][18][19][20][21][22] comprising 1767 OT cases and 229,167 non-cases of OT met the inclusion criteria ( Fig. 1).…”

Section: Literature Searchmentioning

confidence: 99%

“…Overall pooled mean estimates differed insignificantly upon the exclusion of a single study at a time (Table S2), but few studies [7,17,18,21,22] exerted negligible influence on the overall pooled mean estimates of the meta-analysis.…”

Section: Sensitivity Analysismentioning

confidence: 99%

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Lipid profile and risk of ovarian tumours: a meta-analysis

et al. 2020

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Background: Existing data from several reports on the association between lipid profile and ovarian tumour (OT) suggests divergent conclusions. Our aim was to examine whether circulating lipid profile: total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) differed between cases and noncases of OT. Methods: Electronic repositories; PUBMED, EMBASE and Cochrane library were explored through December 2019 to retrieve published articles for inclusion in the meta-analysis after quality assessment. Heterogeneity was assessed using I 2 statistics, the effect of individual studies on the overall effect size was tested using sensitivity analysis and funnel plot was used to evaluate publication bias. Results: Twelve studies, involving 1767 OT cases and 229,167 non-cases of OT were included in this meta-analysis and I 2 statistics ranged between 97 and 99%. Mean circulating TC (− 16.60 [− 32.43, − 0.77]mg/dL; P = 0.04) and HDL (− 0.25[− 0.43, − 0.08]mmol/L; P = 0.005) were significantly lower among OT cases compared to non-OT cases. Conclusion: Decreased TC and HDL profiles were observed among subjects with OT in this collection of reports. The implications of TC and HDL in tumour manifestations and growth need to be validated in a large multi-ethnic longitudinal cohort adjusting for relevant confounders.

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Section: Discussionsupporting

confidence: 87%

Section: Literature Searchmentioning

confidence: 99%

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Lipid profile and risk of ovarian tumours: a meta-analysis

et al. 2020

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“…The end products of lipid peroxidation have an important role in oncogenesis. Thus, oxidized low-density lipoprotein is responsible for the development of oxidative stress-related cancer diseases (4,(50)(51)(52). The results show that PON1 activity also has a vital role in cancer diseases.…”

Section: Resultsmentioning

confidence: 98%

Some Anticancer Agents Act on Human Serum Paraoxonase‐1 to Reduce Its Activity

Alım

Beydemır

2016

Chem Biol Drug Des

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Human serum paraoxonase (hPON1) is an important antioxidant enzyme. It protects low-density lipoproteins against oxidative stress and prevents atherosclerosis development. Anticancer agents have cardiotoxic effects, and this situation can lead to significant complications. Our aim was to evaluate the in vitro effects of some of the anticancer agents such as cetuximab, paclitaxel, etoposide, docetaxel, and ifosfamide on the activity of hPON1 in this study. For this reason, PON1 was purified from human serum with a specific activity of 3654.2 EU/mg and 16.84% yield using simple chromatographic methods. The five chemotherapeutic agents dose dependently decreased in vitro hPON1 activity. IC50 values for cetuximab, paclitaxel, etoposide, docetaxel, and ifosfamide were 0.0111, 0.042, 0.226, 0.665, and 23.3 mm, respectively. Ki constants were 0.0194, 0.0165, 0.131, 0.291, and 8.973 mm, respectively. The inhibition mechanisms of cetuximab, etoposide, docetaxel, and ifosfamide were non-competitive, and for paclitaxel was competitive. Consequently, inhibition of hPON1 by these anticancer agents may explain some of the cardiotoxic actions of these drugs.

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“…Enzymatic methods were used to determine concentrations of total cholesterol (Chol) and triglycerides (TG). HDL-cholesterol was measured after precipitation of apolipoprotein B containing lipoproteins, and LDL-cholesterol level was calculated using Fridewald formulae [34]. Blood levels of PSA were measured in fresh serum using the automated chemiluminescence system.…”

Section: Methodsmentioning

confidence: 99%

Diagnostic Value of Serum Ghrelin Levels in Diabetic Men with Benign Prostate Hypertrophy

Wrzosek¹

2015

J Diabetes Metab

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Introduction: The aim of this study was to assess relations between total ghrelin concentrations, PSA levels and other metabolic parameters in patients with Benign Prostate Hyperplasia (BPH) and in patients with BPH and coexisting Type 2 Diabetes (T2D) due to estimate its diagnostic value. Material and method: Altogether, 21 patients with BPH, 22 patients with BPH and coexisting T2D and 24 control subjects were enrolled in the study. All participants underwent a comprehensive medical evaluation including clinical history and urological examination. The following variables were determined for each subject: total ghrelin, total Prostate-Specific Antigen (PSA), fasting glucose, insulin, C-peptide, glycosylated hemoglobin (HbA1c), triglycerides, total cholesterol, high-density and low-density lipoprotein cholesterol, transaminases and creatinine. Results: Diabetic men with BPH had similar PSA levels as control men without BPH. In addition PSA concentrations were reduced in with coexisting T2D when compared with non-diabetic patients with BPH. There were no statistically significant differences in total ghrelin concentrations between diabetics with BPH as well as non-diabetics with BPH and controls, however, in non-diabetic patients with BPH there was significant positive correlation between serum PSA and total ghrelin concentrations (R=0.638; P=0.002). Discussion: We conclude that reduced concentration of PSA in subjects with coexisting T2D may delay the diagnosis and treatment of BPH in these patients. Further studies are needed to assess the diagnostic role of serum ghrelin levels in diabetic men with BPH.

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Lipids in serum of patients with malignant ovarian neoplasms

Cited by 23 publications

References 16 publications

Lipid profile and risk of ovarian tumours: a meta-analysis

Lipid profile and risk of ovarian tumours: a meta-analysis

Some Anticancer Agents Act on Human Serum Paraoxonase‐1 to Reduce Its Activity

Diagnostic Value of Serum Ghrelin Levels in Diabetic Men with Benign Prostate Hypertrophy

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