Lipids, lipoproteins, and sexual maturation during adolescence: The princeton maturation study

Morrison, John A.; Laskarzewski, Peter M.; Rauh, Joseph L.; Brookman, Richard R.; Mellies, Margot J.; Frazer, Marilyn; Khoury, Philip R.; deGroot, Ido; Kelly, Karen R.; Glueck, Charles J.

doi:10.1016/0026-0495(79)90017-9

Cited by 125 publications

(66 citation statements)

References 27 publications

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“…Although we accounted for age-related changes in the variables, these variables are influenced by the dynamic nature of puberty. [63][64][65] For example, HDL-C and insulin sensitivity both decline during puberty while body fatness, TG, and blood pressure increase. Therefore, biological maturity status presents a major confounding variable that we were not able to account for in this study.…”

Section: Discussionmentioning

confidence: 99%

Aerobic fitness, body mass index, and CVD risk factors among adolescents: the Québec family study

et al. 2005

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PURPOSE:The purpose of this study was to examine the association of body mass index (BMI) and aerobic fitness on cardiovascular disease (CVD) risk factors in adolescents. METHODS: The sample included 416 boys and 345 girls 9-18 y of age from the Québec Family Study. Participants were crosstabulated into four groups using a median split of age-adjusted physical working capacity (PWC) and body mass index (BMI). Group differences in age-adjusted CVD risk factors (blood pressures, fasting total cholesterol (CHOL), LDL -C, HDL-C, HDL/ CHOL, triglycerides, glucose, and a composite risk factor score) were examined by two-way ANOVA. RESULTS: Several CVD risk factors showed significant main effects for PWC, BMI and/or the PWC by BMI interaction. In general, low fit males and females had higher blood lipids and glucose compared to their high fit counterparts within BMI categories although none of the differences reached statistical significance. The high fit/low BMI group showed the best CVD risk factor profile while the low fit/high BMI showed a poorer profile as evidenced by several significant differences between these two groups. Other significant differences occurred for various risk factors between groups. CONCLUSION: Both aerobic fitness and BMI show an independent association with CVD risk factors in adolescents.

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Section: Discussionmentioning

confidence: 99%

Aerobic fitness, body mass index, and CVD risk factors among adolescents: the Québec family study

et al. 2005

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“…participate in the regulation of LDL-cholesterol and triglyceride metabolism in late puberty, as they do in adult men (30 -33), and whether sex steroids contribute to the increase in LDL-cholesterol that occurs in late puberty in boys (12), remain to be clarified.…”

Section: Discussionmentioning

confidence: 99%

“…An increase also occurs in the concentration of low-density lipoprotein cholesterol (LDL-cholesterol) (12,13). A decrease in HDLcholesterol concentration in boys during puberty is related to an increase in testosterone concentration (10, 14 -16).…”

Section: Introductionmentioning

confidence: 99%

The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor

Wickman

Saukkonen

Dunkel

2002

European Journal of Endocrinology

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Objective: Our purpose was to study the sex steroid-mediated changes in serum insulin and lipid concentrations in boys during puberty. Design and Methods: We treated boys with constitutional delay of puberty either with testosterone plus placebo or with testosterone plus an aromatase inhibitor, letrozole, which inhibits the conversion of androgens to oestrogens. We demonstrated previously that during treatment with testosterone plus letrozole the increase in testosterone concentration was more than 5-fold higher than during treatment with testosterone plus placebo. The concentrations of 17b-oestradiol, IGF-I and IGFbinding protein-3 increased during testosterone-plus-placebo treatment, but during testosteroneplus-letrozole treatment the concentrations remained unchanged. These divergent changes in the two groups enabled us to study the effects of sex steroids and GH on insulin sensitivity and lipid concentrations. Results: The insulin concentration in the testosterone-plus-placebo-treated group did not change. In contrast, in the testosterone-plus-letrozole-treated group, the concentration decreased during letrozole treatment, indicating improved insulin sensitivity. Changes in insulin and IGF-I concentrations within 12 and 18 months were correlated. In the testosterone-plus-placebo-treated group, the high-density lipoprotein cholesterol concentration did not change but in the testosterone-plusletrozole-treated group the concentration decreased. The concentrations of low-density lipoprotein cholesterol (LDL-cholesterol) and triglycerides did not change in either of the groups. Conclusions: The findings indicate that androgens do not directly alter insulin sensitivity in boys during puberty. In contrast, the observations suggest tight regulation of glucose -insulin homeostasis by GH in boys at this stage. Furthermore, our findings indicate that sex steroids do not significantly participate in the regulation of serum concentrations of LDL-cholesterol or triglycerides in boys during early and mid-puberty.

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“…Sexual maturation is known to influence lipid levels in children. 57,58 We included adjustments for age and gender in multivariate analyses, but our data cannot exclude an interaction between sexual maturity and the effects of allelic variation on lipid levels. Conversely, lipid levels in children, by comparison to adults, are influenced less by certain environmental factors, including medications, alcohol consumption, and smoking.…”

Section: Discussionmentioning

confidence: 99%

Age-Related Effects of Genetic Variation on Lipid Levels: The Columbia University BioMarkers Study

Talmud

Berglund²,

Hawe

et al. 2001

Pediatrics

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ABSTRACT. Objectives. To examine the genotype: phenotype association in children compared with their parents.Methods. Variations at 4 key gene loci, namely lipoprotein lipase (LPL S447X), hepatic lipase (HL ؊480C>T), cholesteryl ester transfer protein (CETP TaqIB), and apolipoprotein CIII (APOC3 ؊455T>C and ؊482C>T), were examined in children (n ‫؍‬ 495) and their parents (n ‫؍‬ 353) in the Columbia University BioMarkers Study, 1994 to 1998.Results. The frequencies of the rare alleles of the HL ؊480C>T and APOC3 ؊455T>C and ؊482C>T (but not LPL S447X or CETP TaqIB) were significantly lower in non-Hispanic white participants compared with Hispanics. Overall, genotype effects seen in the adults were weaker in the children, although similar trends were seen. In an examination of the effect of body fat on the genotypic effects in the children, there was significant HL ؊480C>T:sum of skinfold interaction.Conclusions. All genotypes were associated with clear relationships to plasma lipid levels in adults, but the effects were weaker in their children, unless stressed by body fat. Pediatrics 2001;108(3). URL: http://www. pediatrics.org/cgi/content/full/108/3/e50; atherosclerosis, cardiovascular disease, child, lipids, genetics.

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Lipids, lipoproteins, and sexual maturation during adolescence: The princeton maturation study

Cited by 125 publications

References 27 publications

Aerobic fitness, body mass index, and CVD risk factors among adolescents: the Québec family study

Aerobic fitness, body mass index, and CVD risk factors among adolescents: the Québec family study

The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor

Age-Related Effects of Genetic Variation on Lipid Levels: The Columbia University BioMarkers Study

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