Lipids methabolism and antioxidant status in exogenous constitutional obesity in girls of Buryatia

Abstract

The study of adolescent obesity and pathogenic factors of its development is getting more and more important as the disease aggravates in adulthood. The serious progress in the study of the pathogenesis of this process can be achieved by analyzing the molecular mechanisms of the obesity development in childhood and adolescence. An individual approach to the diagnosis and treatment of obesity includes various factors, including the patient’s nationality. In recent decades there is an increase in the incidence of obesity among the representatives of the Mongoloid race, which is not characteristic of this racial group. Thus, the aim of the study was to analyze the state of lipid metabolism and the level of antioxidant components in the Buryat girls with exogenous constitutional obesity of the 1st degree. The authors examined 44 girls with exogenous constitutional obesity of the 1st degree and 48 practically healthy adolescent girls (comparison group) of the same age. All the girls belonged to the Buryat ethnic group. They used spectrophotometric and fluorometric research methods. The study revealed that exogenous constitutional obesity in adolescent girls is accompanied by the development of dyslipidemia (increased concentrations of total cholesterol, triacylglycerols, very low density lipoprotein cholesterol, an increase in the atherogenic coefficient, a decreased level of high density lipoprotein cholesterol), as well as a deficiency of antioxidant defense components (decreased levels α-tocopherol, retinol, activity of superoxide dismutase and glutathione-S-transferase). These results expand the understanding of the pathophysiological mechanisms of adolescent obesity and develop individual approaches to the treatment of this condition.

Comorbidity of functional bowel disorders and obesity in terms of microbiome

“…Ожирение является хроническим мультифакторным гетерогенным заболеванием, развивающимся в результате дисбаланса потребления и расхода энергии и проявляющимся избыточным развитием жировой ткани. Данное заболевание несёт для человека высокий кардиометаболический риск и приводит к различным осложнениям [3,[7][8][9][10].…”

Difficulties Of Enterobacteriaceae Genome Annotation In Deciphering Gastrointestinal Microbiome Datasets Obtained By 16S RRNA Gene Amplicon Sequencing

“…Thus, correction of the taxonomic position is required using phylogenetic analysis and sequences of type strains. Our previous studies described the frequency and structure of obesity-associated cardiometabolic risk factors in a cohort of children and adolescents [9], changes in the biochemical status of obese youths [10][11][12], and analyzed the intestinal microbiota [13,14]. Species of Bifidobacterium are present in the gastrointestinal tract of a healthy person, and a change in the number and composition of their species is a sign of intestinal dysbiosis.…”