Lipoates as building blocks of sulfur-containing branched macromolecules

Tang, Houliang; Tsarevsky, Nicolay V.

doi:10.1039/c5py01005e

Cited by 36 publications

(34 citation statements)

References 69 publications

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“…The most commonly used acid-labile linkages are listed in Table 1. The different degradation mechanisms of the linkages and the products after cleavage are described [53,54].…”

Section: Ph-responsive Polymersmentioning

confidence: 99%

Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

et al. 2018

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Cancer remains a leading cause of death worldwide with more than 10 million new cases every year. Tumor-targeted nanomedicines have shown substantial improvements of the therapeutic index of anticancer agents, addressing the deficiencies of conventional chemotherapy, and have had a tremendous growth over past several decades. Due to the pathophysiological characteristics that almost all tumor tissues have lower pH in comparison to normal healthy tissues, among various tumor-targeted nanomaterials, pH-responsive polymeric materials have been one of the most prevalent approaches for cancer diagnosis and treatment. In this review, we summarized the types of pH-responsive polymers, describing their chemical structures and pH-response mechanisms; we illustrated the structure-property relationships of pH-responsive polymers and introduced the approaches to regulating their pH-responsive behaviors; we also highlighted the most representative applications of pH-responsive polymers in cancer imaging and therapy. This review article aims to provide general guidelines for the rational design of more effective pH-responsive nanomaterials for cancer diagnosis and treatment.

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“…The most commonly used acid-labile linkages are listed in Table 1. The different degradation mechanisms of the linkages and the products after cleavage are described [53,54].…”

Section: Ph-responsive Polymersmentioning

confidence: 99%

Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

et al. 2018

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“…Stimuli-responsive or ‘Smart’ polymers are capable of changing their physical and/or chemical properties upon receiving external triggers, such as temperature, pH, redox, mechanical forces, and light [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. These tailor-made polymers are receiving significant interest in the fields of drug delivery, biosensor, tissue engineering, coatings, and self-healing materials [ 10 , 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Progress in Photo-Responsive Polypeptide Derived Nano-Assemblies

Tang

Sun

2018

Micromachines

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Stimuli-responsive polymeric materials have attracted significant attention in a variety of high-value-added and industrial applications during the past decade. Among various stimuli, light is of particular interest as a stimulus because of its unique advantages, such as precisely spatiotemporal control, mild conditions, ease of use, and tunability. In recent years, a lot of effort towards the synthesis of a biocompatible and biodegradable polypeptide has resulted in many examples of photo-responsive nanoparticles. Depending on the specific photochemistry, those polypeptide derived nano-assemblies are capable of crosslinking, disassembling, or morphing into other shapes upon light irradiation. In this review, we aim to assess the current state of photo-responsive polypeptide based nanomaterials. Firstly, those ‘smart’ nanomaterials will be categorized by their photo-triggered events (i.e., crosslinking, degradation, and isomerization), which are inherently governed by photo-sensitive functionalities, including O-nitrobenzyl, coumarin, azobenzene, cinnamyl, and spiropyran. In addition, the properties and applications of those polypeptide nanomaterials will be highlighted as well. Finally, the current challenges and future directions of this subject will be evaluated.

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“…The fundamental concept of reversibility has been widely utilized to drive the development of new polymeric materials, which can display distinct but reversible change in properties upon receiving a stimulus [ 1 , 2 ]. In light of this, a library of reversible materials based on polymers have recently been achieved, including self-healing materials bearing reversible-covalent linkages [ 3 , 4 , 5 , 6 , 7 , 8 ], recyclable materials such as vitrimers [ 9 , 10 , 11 ], polymer networks enabling reversible sol-gel transitions [ 12 , 13 , 14 ], architecture-transformable polymers [ 15 ], and covalent or metal organic frameworks harnessing reversible bonds [ 16 , 17 , 18 , 19 , 20 , 21 ]. Despite the tremendous success in the aforementioned polymer systems, little attention has been paid to achieving reversible polymerizations.…”

Section: Introductionmentioning

confidence: 99%

A Perspective on Reversibility in Controlled Polymerization Systems: Recent Progress and New Opportunities

Tang

Luan

et al. 2018

Molecules

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The field of controlled polymerization is growing and evolving at unprecedented rates, facilitating polymer scientists to engineer the structure and property of polymer materials for a variety of applications. However, the lack of degradability, particularly in vinyl polymers, is a general concern not only for environmental sustainability, but also for biomedical applications. In recent years, there has been a significant effort to develop reversible polymerization approaches in those well-established controlled polymerization systems. Reversible polymerization typically involves two steps, including (i) forward polymerization, which converts small monomers into macromolecule; and (ii) depolymerization, which is capable of regenerating original monomers. Furthermore, recycled monomers can be repolymerized into new polymers. In this perspective, we highlight recent developments of reversible polymerization in those controlled polymerization systems and offer insight into the promise and utility of reversible polymerization systems. More importantly, the current challenges and future directions to solve those problems are discussed. We hope this perspective can serve as an “initiator” to promote continuing innovations in this fairly new area.

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Lipoates as building blocks of sulfur-containing branched macromolecules

Cited by 36 publications

References 69 publications

Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

Progress in Photo-Responsive Polypeptide Derived Nano-Assemblies

A Perspective on Reversibility in Controlled Polymerization Systems: Recent Progress and New Opportunities

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