Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

Tang, Houliang; Zhao, Weilong; Yu, Jinming; Yang, Li; Zhao, Chao

doi:10.3390/molecules24010004

Cited by 179 publications

(111 citation statements)

References 108 publications

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“…In wound healing, the pH value is suggested as a parameter for both diagnostic and theranostic purposes [8]. Moreover, recent advances in the field of stimuli-responsive drug delivery [9,10] allow for utilization of the pH as an endogenous trigger for drug release in wound healing [11] and solid tumors [9,12,13].…”

Section: Introductionmentioning

confidence: 99%

Early pH Changes in Musculoskeletal Tissues upon Injury—Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH

Berkmann

Martin

Ellinghaus

et al. 2020

IJMS

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Local pH is stated to acidify after bone fracture. However, the time course and degree of acidification remain unknown. Whether the acidification pattern within a fracture hematoma is applicable to adjacent muscle hematoma or is exclusive to this regenerative tissue has not been studied to date. Thus, in this study, we aimed to unravel the extent and pattern of acidification in vivo during the early phase post musculoskeletal injury. Local pH changes after fracture and muscle trauma were measured simultaneously in two pre-clinical animal models (sheep/rats) immediately after and up to 48 h post injury. The rat fracture hematoma was further analyzed histologically and metabolomically. In vivo pH measurements in bone and muscle hematoma revealed a local acidification in both animal models, yielding mean pH values in rats of 6.69 and 6.89, with pronounced intra- and inter-individual differences. The metabolomic analysis of the hematomas indicated a link between reduction in tricarboxylic acid cycle activity and pH, thus, metabolic activity within the injured tissues could be causative for the different pH values. The significant acidification within the early musculoskeletal hematoma could enable the employment of the pH for novel, sought-after treatments that allow for spatially and temporally controlled drug release.

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Section: Introductionmentioning

confidence: 99%

Early pH Changes in Musculoskeletal Tissues upon Injury—Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH

Berkmann

Martin

Ellinghaus

et al. 2020

IJMS

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“…Different types of biomaterials with specific characteristics are used as drug carries for efficient delivery of a biomolecule to a specific target [32]. It is worth mentioning that new strategies have emerged to implement therapies with enhanced drug accumulation in the targeted tissue area and decreased side effects [33,34]. Biomaterials, designed for hard tissue engineering and regeneration, exploit different strategies for spatially and temporarily controlled drug delivery with osteoimmunomodulatory properties for efficient osteogenic regeneration [35].…”

Section: Of 19mentioning

confidence: 99%

Macrophage in vitro Response on Hybrid Coatings Obtained by Matrix Assisted Pulsed Laser Evaporation

et al. 2019

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The improvement in the research area of the implant by surface functionalization when correlated with the biological response is of major interest in the biomedical field. Based on the fact that the inflammatory response is directly involved in the ultimate response of the implant within the body, it is essential to study the macrophage-material interactions. Within this context, we have investigated the composite material-macrophage cell interactions and the inflammatory response to these composites with amorphous hydroxyapatite (HA), Lactoferrin (Lf), and polyethylene glycol-polycaprolactone (PEG-PCL) copolymer. All materials are obtained by Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique and characterized by Atomic Force Microscopy and Scanning Electron Microscopy. Macrophage-differentiated THP-1 cells proliferation and metabolic activity were assessed by qualitative and quantitative methods. The secretion of tumor necrosis factor alpha (TNF-α) and interleukin 10 (IL-10) cytokine, in the presence and absence of the inflammatory stimuli (bacterial endotoxin; lipopolysaccharide (LPS)), was measured using an ELISA assay. Our results revealed that the cellular response depended on the physical-chemical characteristics of the coatings. Copolymer-HA-Lf coatings led to low level of pro-inflammatory TNF-α, the increased level of anti-inflammatory IL-10, and the polarization of THP-1 cells towards an M2 pro-reparative phenotype in the presence of LPS. These findings could have important potential for the development of composite coatings in implant applications.

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“…Bu ilaç taşıyıcı sistemlerinin fizyolojik pH değerinde stabilitesini koruması beklenirken, asidik hücre içi bölmelerde hızlı bir şekilde ilaç salımını tetikleyecek şekilde tasarımı yapılmıştır. Bu sistemler, genellikle amin veya karboksilik asit grupları gibi iyonize olabilen fonksiyonel grupların yapıya eklenmesi veya asit parçalanabilir bağ kullanılarak pH'ya duyarlı hale getirilmektedir [11][12][13]. Yapılan çalışmalarda, pluronik polimerleri, D--tokoferil polietilen glikol süksinat (TPGS), siklodekstrin ve kurkumin gibi P-gp inhibitörlerini içeren pH'ya duyarlı sistemlerin ÇİD etkisini büyük ölçüde azalttığı gösterilmiştir [14][15][16].…”

Section: Gi̇ri̇ş (Introduction)unclassified

Potansiyel doksorubisin taşıyıcı sistemi olarak PEG-endozom parçalayıcı peptit konjugatının değerlendirilmesi

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2020

Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi

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Solid phase peptide and PEG conjugation with high efficiency  Preparation of pH sensitive drug delivery systems  Formation of selfassembled nanostructures Figure A. DOX release curves of the mPEG-oxime-DOX and mPEG-peptide-oxime-DOX obtained at pH 7.4 and pH 5.0 Purpose: In this study, it was aimed to assess the physicochemical and doxorubicin (DOX) release properties of a PEGylated TAT-derived peptide carrier system as a preliminary investigation. Theory and Methods: TAT-derived peptide with a sequence of G2RQR3QR3G2S was synthesized using Fmoc strategy in solid state. mPEG-COOH (Mn = 1900 Da) was conjugated to N-terminus of the peptide on the resin. DOX was conjugated to the mPEG-peptide conjugate via acid labile oxime bond. DOX-release, self-assembly, and stability properties of the resultant drug delivery system (DDS) denoted as mPEG-peptide-oxime-DOX were evaluated at pH 5.0 and pH 7.4 and compared with those of the control DDS lack of peptide sequence, mPEG-oxime-DOX. Drug release profiles of the DDSs were obtained using dialysis method. Size distribution and stability of the DDSs were determined via dynamic light scattering. Results: MALDI-TOF-MS analysis results indicated that both the peptide and the conjugate were synthesized successfully. For mPEG-oxime-DOX, pH dependent DOX release was obtained confirming pH responsive property of oxime bond. mPEG-peptide-oxime-DOX seemed to exhibit quite low DOX release (~10-15 %) for both pH, which suggested possible interactions between DOX and the peptide preventing DOX to pass through dialysis membrane. Initial median size (D50) value of the mPEG-oxime-DOX was measured as ~24 nm independent of pH. For mPEG-peptide-oxime-DOX, D50 values were obtained as ~3 nm and ~6 nm at pH 5.0 and pH 7.4, respectively and indicated its pH controlled aggregation behavior. Sizes of both DDSs, tended to increase upon incubation at physiological conditions for 1 day. Conclusion: Comparison of the stability behavior of the similar mPEG-DOX and mPEG-peptide-DOX conjugates developed in our group indicated that longer PEG chains should be used to enhance the stability of these kinds of DDSs.

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Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

Cited by 179 publications

References 108 publications

Early pH Changes in Musculoskeletal Tissues upon Injury—Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH

Early pH Changes in Musculoskeletal Tissues upon Injury—Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH

Macrophage in vitro Response on Hybrid Coatings Obtained by Matrix Assisted Pulsed Laser Evaporation

Potansiyel doksorubisin taşıyıcı sistemi olarak PEG-endozom parçalayıcı peptit konjugatının değerlendirilmesi

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