Lipofuscin- and Melanin-related Fundus Autofluorescence in Patients with ABCA4-associated Retinal Dystrophies

Kellner, Simone; Kellner, Ulrich; Weber, Bernhard H. F.; Fiebig, Britta; Weinitz, Silke; Rüether, Klaus

doi:10.1016/j.ajo.2008.12.023

Cited by 71 publications

(69 citation statements)

References 38 publications

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“…Its clinical value is derived from the fact that it provides a complementary picture of retinal lesions, which from a macroscopic perspective appears to be similar to those visualized using other modalities (most typically compared to short-wavelength autofluorescence) but at a finer scale is often slightly or entirely distinct from other modalities [1,3,[5][6][7]. Unraveling these microscopic nuances could reveal new insights about the mechanisms of disease.…”

Section: Introductionmentioning

confidence: 99%

“…Infrared autofluorescence (IRAF) is an increasingly-utilized clinical modality for visualization and monitoring of the health of the retinal pigment epithelial (RPE) cells in a variety of different diseases that include age-related macular degeneration [1][2][3], central serous chorioretinopathy [4], retinitis pigmentosa [5], ABCA4-associated retinopathies [6], Best vitelliform macular dystrophy [7], and others. Its clinical value is derived from the fact that it provides a complementary picture of retinal lesions, which from a macroscopic perspective appears to be similar to those visualized using other modalities (most typically compared to short-wavelength autofluorescence) but at a finer scale is often slightly or entirely distinct from other modalities [1,3,[5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive near infrared autofluorescence imaging of retinal pigment epithelial cells in the human retina using adaptive optics

Liu

Jung

Liu

et al. 2017

Biomed. Opt. Express

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Abstract:The retinal pigment epithelial (RPE) cells contain intrinsic fluorophores that can be visualized using infrared autofluorescence (IRAF). Although IRAF is routinely utilized in the clinic for visualizing retinal health and disease, currently, it is not possible to discern cellular details using IRAF due to limits in resolution. We demonstrate that the combination of adaptive optics (AO) with IRAF (AO-IRAF) enables higher-resolution imaging of the IRAF signal, revealing the RPE mosaic in the living human eye. Quantitative analysis of visualized RPE cells in 10 healthy subjects across various eccentricities demonstrates the possibility for in vivo density measurements of RPE cells, which range from 6505 to 5388 cells/mm 2 for the areas measured (peaking at the fovea). We also identified cone photoreceptors in relation to underlying RPE cells, and found that RPE cells support on average up to 18.74 cone photoreceptors in the fovea down to an average of 1.03 cone photoreceptors per RPE cell at an eccentricity of 6 mm. Clinical application of AO-IRAF to a patient with retinitis pigmentosa illustrates the potential for AO-IRAF imaging to become a valuable complementary approach to the current landscape of high resolution imaging modalities. References and links1. U. Kellner, S. Kellner, and S. Weinitz, "Fundus autofluorescence (488 nm) and near-infrared autofluorescence (787 nm) visualize different retinal pigment epithelium alterations in patients with age-related macular degeneration," Retina 30(1), 6-15 (2010). 2.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Noninvasive near infrared autofluorescence imaging of retinal pigment epithelial cells in the human retina using adaptive optics

Liu

Jung

Liu

et al. 2017

Biomed. Opt. Express

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“…Durante a nIA com o cSLO, a retina é iluminada com comprimento de onda de 787nm, e o filtro de barreira é idêntico ao utilizado para angiografia com indocianina verde. 16 Contudo, a imagem do fundo ocular obtida é de limitada qualidade.…”

Section: Autofluorescência Com Luz "Infravermelha" (Near-infrared Autunclassified

“…Evidên-cias indicam que a distribuição da nIA se correlaciona diretamente à distribuição da melanina no fundo ocular, com contribuições do EPR e da coróide. 16,17,42,43 Anormalidades de nIA foram reportadas em pacientes com anormalidades genéticas ou degenerativas do EPR, como Doença de Stargardt, retinite pigmentosa, degeneração macular relacionada à idade, retinopatia por cloroquina e coriorretinopatia serosa central (Figura 8). 16,17,43,44 Reflectância com Luz "Infravermelha" (near-Infrared Reflectance, nIR)…”

Section: Autofluorescência Com Luz "Infravermelha" (Near-infrared Autunclassified

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Avaliação ocular multimodal em doenças heredodistróficas e degenerativas da retina

Ferrara¹,

Calucci²,

Oréfice³

et al. 2009

Rev. bras.oftalmol.

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RESUMOA tomografia de coerência óptica incorporou-se gradativamente ao contemporâneo arsenal diagnóstico em Oftalmologia, passando a exercer papel fundamental na investigação e condução de doenças oculares, particularmente na especialidade de Retina e Vítreo. A disponibilização comercial da nova geração de aparelhos, chamada de tomografia de coerência óptica "espectral", baseada em conceito físico distinto que permite a aquisição de imagens em alta velocidade, marcou o início de uma nova era desta tecnologia de investigação auxiliar. Adicionalmente, sua recente combinação com o oftalmoscópio de varredura a laser confocal (confocal scanning laser ophthalmoscope) vem propiciando a aquisição de imagens tomográficas guiadas em tempo real pelos diferentes modos de imagem (autofluorescência de fundo, reflectância com luz "infravermelha" e angiografia com fluoresceína ou indocianina verde). A avaliação ocular multimodal (multimodal fundus imaging) permite a correlação real e minuciosa de achados da morfologia retiniana e do epitélio pigmentar com dados de estudos angiográficos e de autofluorescência ou reflectância, propiciando assim inferências valiosas sobre a fisiologia do tecido. Neste artigo, discutimos brevemente as possíveis implicações da avaliação ocular multimodal na prática da especialidade de Retina e Vítreo.

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Centrifugal Expansion of Fundus Autofluorescence Patterns in Stargardt Disease Over Time

et al. 2012

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Lipofuscin- and Melanin-related Fundus Autofluorescence in Patients with ABCA4-associated Retinal Dystrophies

Cited by 71 publications

References 38 publications

Noninvasive near infrared autofluorescence imaging of retinal pigment epithelial cells in the human retina using adaptive optics

Noninvasive near infrared autofluorescence imaging of retinal pigment epithelial cells in the human retina using adaptive optics

Avaliação ocular multimodal em doenças heredodistróficas e degenerativas da retina

Centrifugal Expansion of Fundus Autofluorescence Patterns in Stargardt Disease Over Time

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