Two compounds showing negative correlation to DDT-resistance in larvae of Musca domestica were found, namely cetyl fluoride (CF) and cetyl fluoroacetate (CFA). Larvae of the DDT-resistant housefly strains K1 and TP were affected more strongly by CFA incorporated in the breeding medium than larvae of the normal reference strains Sv and S-Rome. The same held true for CF, except that the effect on strain TP was doubtful. The chlordane-resistant strain R-Sard. had a normal response to CF and CFA. In larvae of several DDT-resistant, laboratory-developed strains of Anopheles atroparvus, negative correlation to resistance was noted for CF, but not for CFA and cetyl cyanide. The effect of CF applied again only to DDT-resistance, not to dieldrin-resistance.No negative correlation to resistance was found in adults of houseflies and anophelines with regard to CF, CFA, cetyl chloroacetate, cetyl cyanide, cetyl thiocyanate and cetyl bromide.