2021
DOI: 10.1038/s42255-021-00493-6
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Lipolysis: cellular mechanisms for lipid mobilization from fat stores

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Cited by 372 publications
(229 citation statements)
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References 376 publications
(479 reference statements)
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“…A recent study has suggested that LD-related lipotoxicity participates in PD pathology [ 26 ]. Perilipin family members (PLIN1-5), the surrounding proteins of LDs, are regarded as the most important regulator of LDs, facilitating LD movement and cellular signalling interactions [ 27 , 28 ]. We have previously reported that the PLIN4/LD/mitophagy axis has a crucial role in neurodegeneration owing to MPTP/MPP + insult, indicating PLIN4/LDs as a potential biomarker and therapeutic target for PD [ 21 ].…”
Section: Resultsmentioning
confidence: 99%
“…A recent study has suggested that LD-related lipotoxicity participates in PD pathology [ 26 ]. Perilipin family members (PLIN1-5), the surrounding proteins of LDs, are regarded as the most important regulator of LDs, facilitating LD movement and cellular signalling interactions [ 27 , 28 ]. We have previously reported that the PLIN4/LD/mitophagy axis has a crucial role in neurodegeneration owing to MPTP/MPP + insult, indicating PLIN4/LDs as a potential biomarker and therapeutic target for PD [ 21 ].…”
Section: Resultsmentioning
confidence: 99%
“…To compensate for this imbalance, white adipocytes undergo lipolysis, wherein triacylglycerides (TAG) stored in lipid droplets are sequentially hydrolyzed in a series of enzymatic reactions mediated by adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and monoacylglycerol lipase (MGL) to produce and secrete non-esterified free fatty acids into the blood for delivery to tissues. The regulation of lipolysis occurs at the transcriptional, post-translational, and neuroendocrine levels in processes that have recently been reviewed [ 19 , 20 , 21 , 22 ]. The lipolytic process is summarized in the following section and Figure 1 A.…”
Section: Flexible Adipose Tissuementioning
confidence: 99%
“…This sequence is summarized in the Figure 1 A insert. The authors acknowledge that alternative lipases contribute to lipolysis (reviewed elsewhere—[ 19 , 20 , 21 , 22 ]) but have chosen to focus on the canonical ATGL and HSL, as they have been shown to be responsible for nearly 90% of TAG hydrolysis [ 41 ].…”
Section: Flexible Adipose Tissuementioning
confidence: 99%
“…The catabolism of neutral lipids stored in the LD core is achieved by two major mechanisms, lipolysis and lipophagy ( Figure 1A ). During lipolysis, TAG lipases localized at the LD surface, such as Adipose Triglyceride Lipase (ATGL), liberate free fatty acids and diacylglycerol ( Grabner et al, 2021 ). Diacylglycerol can be further hydrolyzed to produce additional free fatty acids by the sequential action of Hormone Sensitive Lipase (HSL) and Monoacylglycerol Lipase (MAGL).…”
Section: Introductionmentioning
confidence: 99%