Lipoma of the Liver Associated with Hepatocellular Carcinoma and Polycystic Liver Disease

Fat-containing tumors of the liver are a heterogeneous group of tumors with characteristic histologic features, variable biologic profiles, and variable imaging findings. Benign liver lesions that contain fat include focal or geographic fatty change (steatosis), pseudolesions due to postoperative packing material (omentum), adenoma, focal nodular hyperplasia, lipoma, angiomyolipoma, cystic teratoma, hepatic adrenal rest tumor, pseudolipoma of the Glisson capsule, and xanthomatous lesions in Langerhans cell histiocytosis. Malignant liver lesions that can contain fat include hepatocellular carcinoma, primary and metastatic liposarcoma, and hepatic metastases. Identification of fat within a liver lesion can be critical in characterization of the lesion. The imaging characteristics of a lesion coupled with the pattern of intratumoral fatty change are helpful in narrowing the differential diagnosis. Although the presence of fat can be demonstrated with computed tomography or ultrasound, magnetic resonance imaging is the most specific imaging technique for demonstration of both microscopic and macroscopic fat.

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“…Hepatic lipomas are extremely uncommon (15). Histologically, these lesions consist of mature adipose tissue.…”

Section: Lipomamentioning

confidence: 99%

Fat-containing Lesions of the Liver: Radiologic-Pathologic Correlation

et al. 2005

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“…Since Ramchand's report, several cases [3][4][5][6][7][8][9][10][11] were reported, and they defi ned the diagnostic features with imaging techniques (ultrasonography, CT scan, magnetic resonance imaging), which differentiate these tumors from hemangioma, metastasis, and others. 12 Angiomyolipoma of the liver is also very uncommon in comparison to that of the kidney.…”

Section: Discussionmentioning

confidence: 99%

A hepatic lipoma mimicking angiomyolipoma of the liver: Report of a case

et al. 2009

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Lipoma of the liver is extremely rare. Since the current knowledge of such tumors is based primarily on individual case reports and small case series, little is so far known about this disease. This report presents a case of lipoma of the liver mimicking angiomyolipoma. The patient was a 38-year-old man, who was hospitalized without any symptoms after a medical check. Radiological examinations (computed tomography, ultrasonography, magnetic resonance imaging) showed a well-defined mass, which was finally diagnosed to be located in the left part of the caudate lobe of the liver, containing two spotty enhanced nodules within the tumor. These were diagnosed to be either lipoma or angiomyolipoma of the liver. The resected specimen measured 9 cm in diameter. The cut surface of the specimen showed an encapsulated, homogeneous, yellowish tumor consisting of mature adipose tissue, which was diagnosed as lipoma of the liver. The two nodules within the tumor were encapsulated hemorrhage. Histopathological examinations revealed the lipoma to be composed of mature lipocytes without angiomatous or myomatous elements. There was no immunoreactivity to homatropine methylbromide 45. Therefore, the final diagnosis was lipoma of the liver, which is an extremely rare benign liver tumor.

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“…As a malignant complication of PLD, a total of 10 cases of cholangiocarcinoma have been reported in the English literature (3)(4)(5), while HCC has only been described in two case reports and the authors did not discuss the etiology (6,7).…”

Section: Introductionmentioning

confidence: 99%

Hepatocellular Carcinoma in a Patient with Polycystic Liver Disease

et al. 2015

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A 49-year-old Japanese woman with polycystic liver disease (PLD) was admitted for right hypochondrial pain. CT showed a huge enhancing mass in the liver. She tested negative for other liver diseases, such as hepatitis B and C and alcoholic liver disease. After the patient expired due to hepatic failure, an autopsy revealed poorly differentiated hepatocellular carcinoma (HCC) surrounded by multiple hepatic cysts. The small amount of residual hepatic parenchyma showed nonalcoholic fatty liver disease (NAFLD) with severe steatosis. Severe emaciation was also apparent. This case suggests that malnutrition in patients with symptomatic PLD may contribute to the development of HCC via NAFLD.

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Lipoma of the Liver Associated with Hepatocellular Carcinoma and Polycystic Liver Disease

Cited by 10 publications

References 7 publications

Fat-containing Lesions of the Liver: Radiologic-Pathologic Correlation

Fat-containing Lesions of the Liver: Radiologic-Pathologic Correlation

A hepatic lipoma mimicking angiomyolipoma of the liver: Report of a case

Hepatocellular Carcinoma in a Patient with Polycystic Liver Disease

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