Lipomatous meningioma: A study of five cases with brief review of literature

Abstract

Lipomatous meningiomas are an uncommon subtype of meningiomas. In the present report, the clinical characteristics, neuroimaing and pathological features of 5 patients (4 males, 1 female; age range, 17-45 years; mean age, 35.2 years) with lipomatous meningioma were analyzed. The neuro-pathological reevaluation of lipomatous meningioma involved assessment of histological features proposed by the current WHO classification. The presence or absence of high whorls, fascicles, solid growth, glial invasion, necrosis and nuclear pleomorphism was assessed. The most common presenting symptom was seizures. Location of tumor was frontal (3 cases), parietal (1 case) and fronto-temporal (1 case). All cases showed radiological features of conventional meningioma. Complete excision of tumor along with involved dura was performed in all the patients. Three tumors were meningothelial and 2 were transitional. Tumoral lipid content was variable from 10% to 30%. In addition, there were microcystic features (2 cases) and psammoma bodies (1 case). No recurrence was noted in any of our cases till the last follow-up. Lipomatous meningioma represents a rare distinctive type of meningioma, with a good prognosis with complete removal.

Lipomatous meningioma: Case report and review of the literature

“…The majority of lipomatous meningiomas reported in the literature have been frontal or frontotemporal in origin with only a few being parietal. [11] Seizures are the most common manifestation for frontal and frontotemporal tumors, while headaches are more common for parietal tumors. [12, 13] Our patient had a history of migraine headaches, which may have been the result of her slowly growing lipomatous meningioma.…”

Intraosseous Lipomatous Meningioma

“…Lipomatous meningiomas are classically WHO grade I tumours with good prognosis following complete removal. There is very limited data on these tumours with less than 50 cases of lipomatous meningiomas being described throughout the literature [ 7 ], and to date none of them have been observed to have intraosseous extension.…”

“…Throughout the English literature 41 cases of lipomatous meningiomas have been described [ 7 ], one associated with a secreting meningioma [ 10 ] and another with a cerebral arteriovenous malformation [ 11 ]. No cases were associated with intraosseous extension, although there has been a previous report of a meningioma occurring at the site of an intraosseous lipoma [ 12 ].…”

Metaplastic meningioma with pure and extensive cartilaginous transformation: A diagnostic dilemma

“…Willis R.A. in 1967 [13] argued that meningocytes are mesenchymal in origin, multipotent mesenchymal cells have the ability to differentiate into fibrous, mucoid, adipose, synovial, meningeal, cartilaginous, osseous, hematopoietic, vascular, or reticuloendothelial tissues and may inappropriately respond to an unknown stimulus (precursor) to produce a metaplastic meningioma. Awadesh, et al in 2011 [14] said that metaplasia is a reversible change in which one adult cell type is replaced by another adult cell type. This may represent an adaptive substitution of cells.…”