2009
DOI: 10.1002/cbic.200900242
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Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: Prediction with mRNA Expression, Chemical Synthesis, and Immunostimulatory Activities

Abstract: Recognize this? Based on predictions from mRNA expression of lipoproteins from Staphylococcus aureus, lipopeptide fragments were chemically synthesized, and their TLR2‐stimulatory activities and cytokine‐induction capabilities were analyzed. All the lipopeptides activated TLR2, but the activities varied depending on their peptide sequences.

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Cited by 19 publications
(24 citation statements)
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“…We synthesized 16 Pam2Cys-containing lipopeptides using S. aureus lipoproteins as a reference [30], and designated them Pam2Cys1-Pam2Cys16 (Table 1). Included as positive controls were the diacyl lipopeptides Pam2CSK4 [31], designated as Pam2CSK19 in this study, and its derivatives Pam2CSK (Pam2Cys17), and Pam2CSK2 (Pam2Cys18).…”
Section: Resultsmentioning
confidence: 99%
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“…We synthesized 16 Pam2Cys-containing lipopeptides using S. aureus lipoproteins as a reference [30], and designated them Pam2Cys1-Pam2Cys16 (Table 1). Included as positive controls were the diacyl lipopeptides Pam2CSK4 [31], designated as Pam2CSK19 in this study, and its derivatives Pam2CSK (Pam2Cys17), and Pam2CSK2 (Pam2Cys18).…”
Section: Resultsmentioning
confidence: 99%
“…The synthesis of lipopeptides was achieved with a combination of solution- and solid-phase methods [30]. Briefly, for the preparation of the Pam2Cys backbone, the protected cysteine (Fmoc-Cys-OtBu) and the iodide (3-iodopropane-1,2-diol) were coupled under basic condition by using Cs 2 CO 3 to give Fmoc-Cys(2,3-dihydroxypropyl)-OtBu, and the subsequent acylation and cleavage of the tBu group gave Fmoc-Pam2Cys-OH [37].…”
Section: Methodsmentioning
confidence: 99%
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“…The synthesis of lipopeptides was achieved with a combination of solution-and solid-phase methods as described (13). Pam2Cys12…”
mentioning
confidence: 99%